18 items (Pseudomonas aeruginosa) - STRING interaction network

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	aruG	Arginine/ornithine succinyltransferase AII subunit; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (340 aa)
	dauB	NAD(P)H-dependent anabolic L-arginine dehydrogenase, DauB; Involved in the anabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, before to be channeled into the AST and/or ATA pathways. DauB catalyzes the synthesis of L-arginine from 2-ketoarginine (2-KA) and ammonium. (315 aa)
	aruS	Probable two-component sensor; Member of the two-component regulatory system AruS/AruR, which is involved in the regulation of the arginine transaminase (ATA) pathway in response to exogeneous L-arginine. Probably functions as a sensor kinase that phosphorylates AruR. (998 aa)
	aruR	Probable two-component response regulator; Member of the two-component regulatory system AruS/AruR, which is involved in the regulation of the arginine transaminase (ATA) pathway in response to exogeneous L-arginine. Regulates transcription of aruH and aruI. (244 aa)
	speA-2	Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (636 aa)
	dauA	FAD-dependent catabolic D-arginine dehydrogenase, DauA; DauA is highly expressed within the cystic fibrosis (CF) lung, and it is required for virulence via the optimal production of hydrogen cyanide, pyocyanine, pyoverdine, rhamnolipid and alginate during biofilm formation. Involved in the catabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, [...] (375 aa)
	aruC	N-succinylglutamate 5-semialdehyde dehydrogenase; Transaminates both N(2)-acetylornithine and N(2)- succinylornithine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa)
	aruF	Arginine/ornithine succinyltransferase AI subunit; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. Also acts on L-ornithine. (338 aa)
	arcD	Arginine/ornithine antiporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (482 aa)
	arcA	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (418 aa)
	arcB	Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (336 aa)
	arcC	Carbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (310 aa)
	aruB	Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (448 aa)
	aruD	Succinylglutamate 5-semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate; Belongs to the aldehyde dehydrogenase family. AstD subfamily. (488 aa)
	aruH	Arginine:Pyruvate Transaminase, AruH; Catalyzes the conversion of L-arginine into 2-ketoarginine via transamination. L-arginine is the best substrate, but it can also use L-lysine, L-methionine, L-leucine, ornithine and L-glutamine, which indicates that it may have a broader physiological function in amino acid catabolism. (393 aa)
	aruI	2-ketoarginine decarboxylase, AruI; Catalyzes the decarboxylation of 2-ketoarginine, leading to the formation of 4-guanidinobutyraldehyde. (559 aa)
	aruE	Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (332 aa)
	gbuA	Guanidinobutyrase; Catalyzes specifically the hydrolysis of 4-guanidinobutanoate to 4-aminobutanoate and urea. Has no activity against arginine, agmatine, 3-guanidinopropionate and guanidinoacetate. (319 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
arcA	arcB	PA5171	PA5172	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.	0.999
arcA	arcC	PA5171	PA5173	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Carbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.999
arcA	arcD	PA5171	PA5170	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Arginine/ornithine antiporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.	0.998
arcA	aruF	PA5171	PA0896	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Arginine/ornithine succinyltransferase AI subunit; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. Also acts on L-ornithine.	0.820
arcA	aruG	PA5171	PA0897	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Arginine/ornithine succinyltransferase AII subunit; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.837
arcA	aruH	PA5171	PA4976	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Arginine:Pyruvate Transaminase, AruH; Catalyzes the conversion of L-arginine into 2-ketoarginine via transamination. L-arginine is the best substrate, but it can also use L-lysine, L-methionine, L-leucine, ornithine and L-glutamine, which indicates that it may have a broader physiological function in amino acid catabolism.	0.814
arcA	dauB	PA5171	PA3862	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	NAD(P)H-dependent anabolic L-arginine dehydrogenase, DauB; Involved in the anabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, before to be channeled into the AST and/or ATA pathways. DauB catalyzes the synthesis of L-arginine from 2-ketoarginine (2-KA) and ammonium.	0.804
arcA	speA-2	PA5171	PA4839	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.	0.826
arcB	arcA	PA5172	PA5171	Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.999
arcB	arcC	PA5172	PA5173	Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.	Carbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.999
arcB	arcD	PA5172	PA5170	Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.	Arginine/ornithine antiporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.	0.993
arcB	aruC	PA5172	PA0895	Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.	N-succinylglutamate 5-semialdehyde dehydrogenase; Transaminates both N(2)-acetylornithine and N(2)- succinylornithine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	0.741
arcB	dauB	PA5172	PA3862	Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.	NAD(P)H-dependent anabolic L-arginine dehydrogenase, DauB; Involved in the anabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, before to be channeled into the AST and/or ATA pathways. DauB catalyzes the synthesis of L-arginine from 2-ketoarginine (2-KA) and ammonium.	0.814
arcC	arcA	PA5173	PA5171	Carbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.999
arcC	arcB	PA5173	PA5172	Carbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.	0.999
arcC	arcD	PA5173	PA5170	Carbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Arginine/ornithine antiporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.	0.995
arcD	arcA	PA5170	PA5171	Arginine/ornithine antiporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.	Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.998
arcD	arcB	PA5170	PA5172	Arginine/ornithine antiporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.	Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.	0.993
arcD	arcC	PA5170	PA5173	Arginine/ornithine antiporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.	Carbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.995
aruB	aruC	PA0899	PA0895	Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2).	N-succinylglutamate 5-semialdehyde dehydrogenase; Transaminates both N(2)-acetylornithine and N(2)- succinylornithine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.	0.996