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| | mmsA | Methylmalonate-semialdehyde dehydrogenase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the aldehyde dehydrogenase family. (497 aa) |
| | bauC | Probable aldehyde dehydrogenase; Involved in the degradation of beta-alanine. (497 aa) |
| | gabD | Succinate-semialdehyde dehydrogenase; Catalyzes the conversion of 5-oxopentanoate (glutarate semialdehyde) to glutarate. Involved in L-lysine degradation. (483 aa) |
| | gabT | 4-aminobutyrate aminotransferase; Catalyzes the conversion of 5-aminovalerate to 5- oxopentanoate. (426 aa) |
| | ilvA1 | Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (504 aa) |
| | PA0467 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (206 aa) |
| | PA0473 | Probable glutathione S-transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (249 aa) |
| | PA0656 | Probable HIT family protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (112 aa) |
| | PA0743 | Probable 3-hydroxyisobutyrate dehydrogenase; NAD-dependent L-serine dehydrogenase that catalyzes the oxidation of L-serine and methyl-L-serine and is possibly involved in serine catabolism. Has low activity toward beta-hydroxyisobutyrate. (298 aa) |
| | PA0744 | Probable enoyl-CoA hydratase/isomerase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (367 aa) |
| | PA0747 | Probable aldehyde dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (502 aa) |
| | putA | Proline dehydrogenase PutA; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1060 aa) |
| | putP | Sodium/proline symporter PutP; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (506 aa) |
| | PA0812 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (431 aa) |
| | oruR | Transcriptional regulator OruR; Probably activates the ArgJ gene that encodes ornithine acetyltransferase. Binds to its own promoter-operator region. Probably binds ornithine. (339 aa) |
| | PA0851 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (320 aa) |
| | hpd | 4-hydroxyphenylpyruvate dioxygenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the 4HPPD family. (357 aa) |
| | phhA | Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (262 aa) |
| | phhR | Transcriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (519 aa) |
| | aruC | N-succinylglutamate 5-semialdehyde dehydrogenase; Transaminates both N(2)-acetylornithine and N(2)- succinylornithine; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (406 aa) |
| | aruF | Arginine/ornithine succinyltransferase AI subunit; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine. Also acts on L-ornithine. (338 aa) |
| | aruG | Arginine/ornithine succinyltransferase AII subunit; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (340 aa) |
| | aruD | Succinylglutamate 5-semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate; Belongs to the aldehyde dehydrogenase family. AstD subfamily. (488 aa) |
| | aruB | Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (448 aa) |
| | aruE | Succinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (332 aa) |
| | PA0902 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (334 aa) |
| | lhpD | Probable L-malate dehydrogenase; Catalyzes the reduction of both Delta(1)-pyrroline-2- carboxylate (Pyr2C) and Delta(1)-piperideine-2-carboxylate (Pip2C) to L-proline and L-pipecolate, respectively, using NADPH as the electron donor. Cannot use NADH instead of NADPH. Is likely involved in a degradation pathway that converts trans-3-hydroxy-L-proline (t3LHyp) to L-proline, which would allow P.aeruginosa to grow on t3LHyp as a sole carbon source. Can also catalyze the reverse oxidation reactions, albeit at a much lower rate. Is also able to use Delta(1)-pyrroline- (4S)-hydroxy-2-carboxyl [...] (334 aa) |
| | PA1253 | Probable semialdehyde dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (526 aa) |
| | PA1254 | Probable dihydrodipicolinate synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the DapA family. (305 aa) |
| | PA1259 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (580 aa) |
| | PA1266 | Probable oxidoreductase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (417 aa) |
| | PA1267 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (371 aa) |
| | ilvA2 | Threonine dehydratase, biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (515 aa) |
| | ansB | Glutaminase-asparaginase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the asparaginase 1 family. (362 aa) |
| | gbuA | Guanidinobutyrase; Catalyzes specifically the hydrolysis of 4-guanidinobutanoate to 4-aminobutanoate and urea. Has no activity against arginine, agmatine, 3-guanidinopropionate and guanidinoacetate. (319 aa) |
| | sucB | Dihydrolipoamide succinyltransferase (E2 subunit); E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (409 aa) |
| | glsA | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences); Belongs to the glutaminase family. (302 aa) |
| | PA1829 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (356 aa) |
| | maiA | Maleylacetoacetate isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the GST superfamily. Zeta family. (212 aa) |
| | fahA | Fumarylacetoacetase; Product name confidence: Class 2 (High similarity to functionally studied protein). (432 aa) |
| | hmgA | Homogentisate 1,2-dioxygenase; Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate. (432 aa) |
| | liuE | 3-hydroxy-3-methylglutaryl-CoA lyase; Involved in the L-leucine, isovalerate and acyclic monoterpene catabolism. Catalyzes the cleavage of 3-hydroxy-3- methylglutaryl-CoA (HMG-CoA) to yield acetyl-CoA and acetoacetate. It can also catalyze the cleavage of 3-hydroxy-3-isohexenylglutaryl-CoA (HIHG_CoA) to yield 7-methyl-3-oxooct-6-enoyl-CoA and acetate. (300 aa) |
| | liuD | methylcrotonyl-CoA carboxylase, alpha-subunit (biotin-containing); Class 1: Function experimentally demonstrated in P. aeruginosa. (655 aa) |
| | liuC | Putative 3-methylglutaconyl-CoA hydratase; Class 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene; Belongs to the enoyl-CoA hydratase/isomerase family. (265 aa) |
| | liuB | methylcrotonyl-CoA carboxylase, beta-subunit; Class 1: Function experimentally demonstrated in P. aeruginosa. (535 aa) |
| | liuA | Putative isovaleryl-CoA dehydrogenase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (387 aa) |
| | kynU | Kynureninase KynU; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (416 aa) |
| | kynB | Kynurenine formamidase, KynB; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation; Belongs to the Cyclase 1 superfamily. KynB family. (213 aa) |
| | bkdA1 | 2-oxoisovalerate dehydrogenase (alpha subunit); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity); Belongs to the BCKDHA family. (410 aa) |
| | bkdA2 | 2-oxoisovalerate dehydrogenase (beta subunit); The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). (350 aa) |
| | PA2323 | Probable glyceraldehyde-3-phosphate dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (541 aa) |
| | PA2355 | Probable FMNH2-dependent monooxygenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (394 aa) |
| | gcvT2 | Glycine cleavage system protein T2; Product name confidence: Class 2 (High similarity to functionally studied protein). (373 aa) |
| | glyA2 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa) |
| | gcvP2 | Glycine cleavage system protein P2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. (959 aa) |
| | gcvH2 | Glycine cleavage system protein H2; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa) |
| | PA2449 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (511 aa) |
| | PA2473 | Probable glutathione S-transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (214 aa) |
| | catB | Muconate cycloisomerase I; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the mandelate racemase/muconate lactonizing enzyme family. (373 aa) |
| | kynA | L-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing) KynA; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (288 aa) |
| | PA2761 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (138 aa) |
| | atuC | geranyl-CoA carboxylase, beta-subunit; Class 1: Function experimentally demonstrated in P. aeruginosa. (538 aa) |
| | gdhB | NAD-dependent glutamate dehydrogenase; Involved in arginine catabolism by converting L-glutamate, into 2-oxoglutarate, which is then channeled into the tricarboxylic acid cycle. Can also utilize other amino acids of the glutamate family. (1620 aa) |
| | PA3174 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (242 aa) |
| | hutG-2 | Probable arginase family protein; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (311 aa) |
| | dsdA | D-serine dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the serine/threonine dehydratase family. DsdA subfamily. (448 aa) |
| | PA3416 | Probable pyruvate dehydrogenase E1 component, beta chain; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (333 aa) |
| | mmsB | 3-hydroxyisobutyrate dehydrogenase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (298 aa) |
| | PA3844 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (203 aa) |
| | dauB | NAD(P)H-dependent anabolic L-arginine dehydrogenase, DauB; Involved in the anabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, before to be channeled into the AST and/or ATA pathways. DauB catalyzes the synthesis of L-arginine from 2-ketoarginine (2-KA) and ammonium. (315 aa) |
| | dauA | FAD-dependent catabolic D-arginine dehydrogenase, DauA; DauA is highly expressed within the cystic fibrosis (CF) lung, and it is required for virulence via the optimal production of hydrogen cyanide, pyocyanine, pyoverdine, rhamnolipid and alginate during biofilm formation. Involved in the catabolism of D-lysine and D-arginine. Under aerobic conditions, the arginine succinyltransferase (AST) and arginine transaminase (ATA) pathways are 2 major routes for L-arginine utilization as the sole source of carbon and nitrogen. The D-to-L racemization of arginine by DauA and DauB is necessary, [...] (375 aa) |
| | piv | Protease IV; Lysine-specific endoprotease. Involved in corneal virulence; Belongs to the peptidase S1 family. (462 aa) |
| | PA4184 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (340 aa) |
| | PA4401 | Probable glutathione S-transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (211 aa) |
| | glyA3 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | PA4796 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (155 aa) |
| | speA-2 | Biosynthetic arginine decarboxylase; Catalyzes the biosynthesis of agmatine from arginine. Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily. (636 aa) |
| | aruH | Arginine:Pyruvate Transaminase, AruH; Catalyzes the conversion of L-arginine into 2-ketoarginine via transamination. L-arginine is the best substrate, but it can also use L-lysine, L-methionine, L-leucine, ornithine and L-glutamine, which indicates that it may have a broader physiological function in amino acid catabolism. (393 aa) |
| | aruI | 2-ketoarginine decarboxylase, AruI; Catalyzes the decarboxylation of 2-ketoarginine, leading to the formation of 4-guanidinobutyraldehyde. (559 aa) |
| | aruS | Probable two-component sensor; Member of the two-component regulatory system AruS/AruR, which is involved in the regulation of the arginine transaminase (ATA) pathway in response to exogeneous L-arginine. Probably functions as a sensor kinase that phosphorylates AruR. (998 aa) |
| | aruR | Probable two-component response regulator; Member of the two-component regulatory system AruS/AruR, which is involved in the regulation of the arginine transaminase (ATA) pathway in response to exogeneous L-arginine. Regulates transcription of aruH and aruI. (244 aa) |
| | dtd | Conserved hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (145 aa) |
| | dadA2 | Probable oxidoreductase; Oxidative deamination of D-amino acids. (416 aa) |
| | hutG | N-formylglutamate amidohydrolase; Product name confidence: Class 2 (High similarity to functionally studied protein). (266 aa) |
| | hutI | Imidazolone-5-propionate hydrolase HutI; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the metallo-dependent hydrolases superfamily. HutI family. (402 aa) |
| | PA5093 | Probable histidine/phenylalanine ammonia-lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (510 aa) |
| | hutH | Histidine ammonia-lyase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the PAL/histidase family. (509 aa) |
| | hutU | Urocanase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (559 aa) |
| | hutC | Histidine utilization repressor HutC; Repressor which binds to the hutP region in the histidine utilization (hut) operon. It blocks the expression of all the hut genes in the absence of inducer (By similarity). (250 aa) |
| | PA5106 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (453 aa) |
| | arcD | Arginine/ornithine antiporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (482 aa) |
| | arcA | Arginine deiminase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (418 aa) |
| | arcB | Ornithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (336 aa) |
| | arcC | Carbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (310 aa) |
| | gcvP1 | Glycine cleavage system protein P1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. (958 aa) |
| | gcvH1 | Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa) |
| | gcvT1 | Glycine-cleavage system protein T1; The glycine cleavage system catalyzes the degradation of glycine. (360 aa) |
| | dadA | D-amino acid dehydrogenase, small subunit; Catalyzes the oxidative deamination of D-amino acids. Has very broad substrate specificity; all the D-amino acids tested can be used as the substrate except D-Glu and D-Gln. Participates in the utilization of several D-amino acids as the sole source of nitrogen, i.e. D-alanine, D-histidine, D-phenylalanine, D-serine, D-threonine, and D-valine. (432 aa) |
| | lrp | Leucine-responsive regulatory protein; Product name confidence: Class 2 (High similarity to functionally studied protein). (162 aa) |
| | PA5326 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (402 aa) |
| | cdhC | CdhC, Carnitine dehydrogenase-related protein C; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (294 aa) |
| | ltaA | Low specificity l-threonine aldolase; Catalyzes the cleavage of L-allo-threonine and L-threonine to glycine and acetaldehyde. (346 aa) |
| | glyA1 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa) |
| | soxB | Sarcosine oxidase beta subunit; Class 1: Function experimentally demonstrated in P. aeruginosa. (416 aa) |
| | soxD | Sarcosine oxidase delta subunit; Class 1: Function experimentally demonstrated in P. aeruginosa. (106 aa) |
| | soxA | Sarcosine oxidase alpha subunit; Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the GcvT family. (1005 aa) |
| | soxG | Sarcosine oxidase gamma subunit; Class 1: Function experimentally demonstrated in P. aeruginosa. (211 aa) |
