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| | ntrC | Two-component response regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (476 aa) |
| | dctB | Probable two-component sensor; Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals (By similarity). (612 aa) |
| | dctD | Probable two-component response regulator; Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. (462 aa) |
| | amgS | AmgS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (439 aa) |
| | amgR | AmgR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (247 aa) |
| | algR | Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway. (248 aa) |
| | algZ | Alginate biosynthesis protein AlgZ/FimS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (358 aa) |
| | phoB | Two-component response regulator PhoB; This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited. (229 aa) |
| | phoR | Two-component sensor PhoR; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. (443 aa) |
| | PA5364 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (300 aa) |
| | algB | Two-component response regulator AlgB; Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. Positive regulator of the alginate biosynthetic gene AlgD. (449 aa) |
| | PA5484 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (595 aa) |
| | mifR | MifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (447 aa) |
| | mifS | MifS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (588 aa) |
| | PA0033 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (121 aa) |
| | PA0034 | Probable two-component response regulator; Probable transcriptional regulator. (207 aa) |
| | cheB2 | Probable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. (349 aa) |
| | PA0178 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (639 aa) |
| | PA0179 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (121 aa) |
| | PA0267 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (399 aa) |
| | pilG | Twitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions. (135 aa) |
| | pilH | Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (121 aa) |
| | chpA | Component of chemotactic signal transduction system; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (2472 aa) |
| | chpB | Probable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (343 aa) |
| | creB | Two-component response regulator CreB; Product name confidence: Class 2 (High similarity to functionally studied protein). (229 aa) |
| | creC | Two-component sensor CreC; Product name confidence: Class 2 (High similarity to functionally studied protein). (474 aa) |
| | PA0601 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (210 aa) |
| | PA0756 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (223 aa) |
| | PA0757 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (460 aa) |
| | gacS | Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). (925 aa) |
| | PA0929 | Two-component response regulator; Product name confidence: Class 2 (High similarity to functionally studied protein). (239 aa) |
| | PA0930 | Two-component sensor; Product name confidence: Class 2 (High similarity to functionally studied protein). (445 aa) |
| | PA0991 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (125 aa) |
| | fleS | Two-component sensor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (402 aa) |
| | fleR | Two-component response regulator; Plays a role in the regulation of both flagellar synthesis and adhesion to mucin. (473 aa) |
| | PA1157 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (236 aa) |
| | PA1158 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (452 aa) |
| | phoP | Two-component response regulator PhoP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (225 aa) |
| | phoQ | Two-component sensor PhoQ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (448 aa) |
| | PA1243 | Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (858 aa) |
| | PA1335 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (425 aa) |
| | PA1336 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (633 aa) |
| | PA1396 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (540 aa) |
| | PA1397 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (210 aa) |
| | PA1437 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (229 aa) |
| | PA1438 | Probable two-component sensor; Member of a two-component regulatory system. (481 aa) |
| | cheY | Two-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation. (124 aa) |
| | PA1458 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (753 aa) |
| | cheB1 | Probable methyltransferase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. (368 aa) |
| | PA1484 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (268 aa) |
| | PA1611 | Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (651 aa) |
| | kdpD | Two-component sensor KdpD; Product name confidence: Class 2 (High similarity to functionally studied protein). (885 aa) |
| | kdpE | Two-component response regulator KdpE; Product name confidence: Class 2 (High similarity to functionally studied protein). (230 aa) |
| | PA1785 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (192 aa) |
| | parS | Two-component sensor, ParS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (428 aa) |
| | parR | Two-component response regulator, ParR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (235 aa) |
| | fimL | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (562 aa) |
| | ercS | ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (881 aa) |
| | erbR | Response regulator ErbR; Positive activator for glycerol metabolism. (221 aa) |
| | eraS | Sensor kinase, EraS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (216 aa) |
| | eraR | Response regulator EraR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (225 aa) |
| | ercS-2 | ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (564 aa) |
| | PA2137 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (178 aa) |
| | PA2177 | Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (699 aa) |
| | PA2376 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (213 aa) |
| | PA2479 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (226 aa) |
| | PA2480 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (440 aa) |
| | PA2523 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (224 aa) |
| | PA2524 | Probable two-component sensor; Member of a two-component regulatory system. (472 aa) |
| | PA2571 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (470 aa) |
| | PA2572 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (447 aa) |
| | PA2583 | Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (992 aa) |
| | gacA | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. (214 aa) |
| | PA2591 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (268 aa) |
| | PA2656 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (445 aa) |
| | PA2657 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (223 aa) |
| | pfeR | Two-component response regulator PfeR; Member of the two-component regulatory system PfeR/PfeS. Activates expression of the ferric enterobactin receptor. (305 aa) |
| | PA0600 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (797 aa) |
| | pfeS | Two-component sensor PfeS; Member of the two-component regulatory system PfeR/PfeS. May activate PfeR by phosphorylation. (446 aa) |
| | PA2798 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (394 aa) |
| | copR | Two-component response regulator, CopR; Class 1: Function experimentally demonstrated in P. aeruginosa. (226 aa) |
| | copS | Two-component sensor, CopS; Member of a two-component regulatory system. (443 aa) |
| | PA2824 | Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (786 aa) |
| | PA2881 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (303 aa) |
| | PA2882 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (371 aa) |
| | PA2899 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (212 aa) |
| | PA3044 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (741 aa) |
| | PA3045 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (207 aa) |
| | PA3077 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (223 aa) |
| | PA3078 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (431 aa) |
| | PA3191 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (473 aa) |
| | gltR | Two-component response regulator GltR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (242 aa) |
| | PA3204 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (225 aa) |
| | PA3206 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (445 aa) |
| | cyaB | CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (463 aa) |
| | PA3271 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (1159 aa) |
| | PA3345 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (116 aa) |
| | PA3346 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (571 aa) |
| | PA3349 | Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (310 aa) |
| | PA3462 | Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (919 aa) |
| | PA3599 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (261 aa) |
| | erdR | Response regulator ErdR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (217 aa) |
| | wspR | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (347 aa) |
| | wspF | Probable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (335 aa) |
| | wspE | Probable chemotaxis sensor/effector fusion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (769 aa) |
| | PA3714 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (213 aa) |
| | narX | Two-component sensor NarX; Product name confidence: Class 2 (High similarity to functionally studied protein). (622 aa) |
| | narL | Two-component response regulator NarL; Product name confidence: Class 2 (High similarity to functionally studied protein). (219 aa) |
| | rocS1 | Probable two-component sensor; Class 1: Function experimentally demonstrated in P. aeruginosa. (1212 aa) |
| | rocR | RocR; Class 1: Function experimentally demonstrated in P. aeruginosa. (392 aa) |
| | rocA1 | Two-component response regulator RocA1; Class 1: Function experimentally demonstrated in P. aeruginosa. (209 aa) |
| | ladS | Lost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (795 aa) |
| | PA4032 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (238 aa) |
| | PA4036 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (766 aa) |
| | PA4080 | Probable response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (214 aa) |
| | bfmR | BfmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (246 aa) |
| | bfmS | BfmS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (434 aa) |
| | PA4112 | Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (1417 aa) |
| | bphP | Bacterial phytochrome, BphP; Photoreceptor which exists in two forms that are reversibly interconvertible by light: the R form that absorbs maximally in the red region of the spectrum and the FR form that absorbs maximally in the far-red region; In the N-terminal section; belongs to the phytochrome family. (728 aa) |
| | bfiR | BfiR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (214 aa) |
| | bfiS | BfiS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (758 aa) |
| | pprA | Two-component sensor PprA; Member of the two-component regulatory system PprA/PprB involved in biofilm formation by controlling the expression of many related genes including type IVb pili major subunit flp pilin, adhesin bapA or cupE fimbriae. Modulates also quorum-sensing signal production acting on both negative and positive modulators. Functions as a heme sensor histidine kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to PprB. (922 aa) |
| | pprB | Two-component response regulator, PprB; Member of the two-component regulatory system PprA/PprB involved in biofilm formation by controlling the expression of many related genes including type IVb pili major subunit flp pilin, adhesin bapA or cupE fimbriae. Modulates also quorum-sensing signal production acting on both negative and positive modulators. Functions as a transcription regulator by direct binding to promoter regions. Negatively regulates its own transcription. (275 aa) |
| | PA4380 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (426 aa) |
| | PA4381 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (227 aa) |
| | PA4396 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (366 aa) |
| | PA4398 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (698 aa) |
| | roxR | RoxR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (186 aa) |
| | roxS | RoxS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (422 aa) |
| | pilS | Two-component sensor PilS; Member of the two-component regulatory system PilS/PilR involved in the regulation of the expression of type 4 fimbriae. PilS may function as a membrane-associated protein kinase that phosphorylates PilR in response to environmental signals. (530 aa) |
| | pilR | Two-component response regulator PilR; Member of the two-component regulatory system PilS/PilR that regulates the expression of type 4 fimbriae. When activated by PilS it acts in conjunction with sigma-54 as a transcriptional activator. (445 aa) |
| | PA4608 | Hypothetical protein; Binds the second messenger bis-(3'-5') cyclic dimeric guanosine monophosphate (c-di-GMP). Can bind two c-di-GMP molecules per monomer. May play a role in bacterial second-messenger regulated processes. Binding to c-di-GMP induces a conformational change of the C- and N-termini resulting in the exposure of a highly negative surface on one side of the protein to a possible effector protein. (125 aa) |
| | cbrA | Two-component sensor CbrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (983 aa) |
| | cbrB | Two-component response regulator CbrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (478 aa) |
| | pmrA | PmrA: two-component regulator system response regulator PmrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (221 aa) |
| | pmrB | PmrB: two-component regulator system signal sensor kinase PmrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (477 aa) |
| | PA4781 | Cyclic di-GMP phosphodiesterase; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP. Hydrolyzes c-di-GMP to GMP in a two-step reaction, via the linear intermediate 5'-phosphoguanylyl(3'->5')guanosine (pGpG). In vitro, can use pGpG as an alternative substrate and hydrolyze it into GMP. Acts in regulation of motility, synthesis of virulence determinants and biofilm architecture. May act preferentially as a pGpG binding protein. (393 aa) |
| | PA4806 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (227 aa) |
| | PA4843 | Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (542 aa) |
| | retS | RetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa) |
| | irlR | Two-component response regulator; Product name confidence: Class 2 (High similarity to functionally studied protein). (229 aa) |
| | PA4886 | Probable two-component sensor; Member of a two-component regulatory system. (463 aa) |
| | fimX | FimX; Class 1: Function experimentally demonstrated in P. aeruginosa. (691 aa) |
| | aruS | Probable two-component sensor; Member of the two-component regulatory system AruS/AruR, which is involved in the regulation of the arginine transaminase (ATA) pathway in response to exogeneous L-arginine. Probably functions as a sensor kinase that phosphorylates AruR. (998 aa) |
| | aruR | Probable two-component response regulator; Member of the two-component regulatory system AruS/AruR, which is involved in the regulation of the arginine transaminase (ATA) pathway in response to exogeneous L-arginine. Regulates transcription of aruH and aruI. (244 aa) |
| | ntrB | Two-component sensor NtrB; Product name confidence: Class 2 (High similarity to functionally studied protein). (358 aa) |
