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| | dxs | 1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (627 aa) |
| | lptA | Lysophosphatidic acid acyltransferase, LptA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (257 aa) |
| | gmhB | Conserved hypothetical protein; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position; Belongs to the GmhB family. (178 aa) |
| | PA0011 | Probable 2-OH-lauroyltransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (295 aa) |
| | mdcC | Malonate decarboxylase delta subunit; Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism. (99 aa) |
| | mdcD | Malonate decarboxylase beta subunit; Product name confidence: Class 2 (High similarity to functionally studied protein). (287 aa) |
| | PA0214 | Probable acyl transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (310 aa) |
| | pcaF | Beta-ketoadipyl CoA thiolase PcaF; Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA. (401 aa) |
| | PA0276 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (171 aa) |
| | PA0358 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (192 aa) |
| | PA0368 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (332 aa) |
| | gcdH | glutaryl-CoA dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein). (393 aa) |
| | PA0449 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (179 aa) |
| | PA0493 | Probable biotin-requiring enzyme; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (82 aa) |
| | plsY | Conserved hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (189 aa) |
| | migA | Alpha-1,6-rhamnosyltransferase MigA; Class 1: Function experimentally demonstrated in P. aeruginosa. (299 aa) |
| | PA0745 | Probable enoyl-CoA hydratase/isomerase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the enoyl-CoA hydratase/isomerase family. (272 aa) |
| | prpD | Propionate catabolic protein PrpD; Product name confidence: Class 2 (High similarity to functionally studied protein). (494 aa) |
| | PA0793 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (395 aa) |
| | PA0794 | Probable aconitate hydratase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (868 aa) |
| | prpC | Citrate synthase 2; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the citrate synthase family. (375 aa) |
| | prpB | Carboxyphosphonoenolpyruvate phosphonomutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (298 aa) |
| | PA0845 | Conserved hypothetical protein; Catalyzes the cleavage of the N-acyl linkage of the ceramides (Cers) to yield sphingosine (Sph) and free fatty acid at an optimal pH of 8-9. Also catalyzes the synthesis of Cers from Sph and fatty acid. (670 aa) |
| | PA0879 | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (386 aa) |
| | PA0938 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (442 aa) |
| | pqsC | PqsC; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. First, PqsC acquires an octanoyl group from octanoyl-CoA and forms an octanoyl-PqsC intermediate. Then, together with PqsB, it catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and re [...] (348 aa) |
| | pqsD | 3-oxoacyl-[acyl-carrier-protein] synthase III; Required for the biosynthesis of a number of signaling molecules, such as the quinolone signal 2-heptyl-3-hydroxy-4(1H)- quinolone (PQS), 2-heptyl-4-hydroxyquinoline (HHQ) and 2,4- dihydroxyquinoline (DHQ). These molecules are required for normal biofilm formation. Catalyzes the transfer of the anthraniloyl moiety from anthraniloyl-CoA to malonyl-CoA to form 2-aminobenzoylacetyl-CoA. The first step of the reaction is the formation of a covalent anthraniloyl-PqsD intermediate. Next, the short-lived intermediate 3-(2-aminophenyl)- 3-oxopropa [...] (337 aa) |
| | PA1014 | Probable glycosyl transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (330 aa) |
| | PA1018 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (288 aa) |
| | PA1023 | Probable short-chain dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (305 aa) |
| | rhlC | Rhamnosyltransferase 2; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (325 aa) |
| | loxA | Probable lipoxygenase; Exhibits lipoxin synthase activity as part of a bacterial evasion strategy to suppress the host immune defense. Oxygenates polyenoic fatty acids including eicosatrienoate and docosahexaenoate to the corresponding (n-6)S-hydroperoxy derivatives. In turn, this production of bioactive lipid mediators promotes bacterial persistence in host lung tissues by inhibiting the expression of major chemokines and recruitment of leukocytes. (685 aa) |
| | PA1187 | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (379 aa) |
| | fabF2 | 3-oxoacyl-acyl carrier protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (422 aa) |
| | PA1400 | Probable pyruvate carboxylase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (1095 aa) |
| | ccmC | Heme exporter protein CcmC; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (252 aa) |
| | PA1535 | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (382 aa) |
| | acnA | Aconitate hydratase 1; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis- aconitate. Could catalyze the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnA functions as a RNA-binding regulatory protein. (910 aa) |
| | fabB | beta-ketoacyl-ACP synthase I; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (405 aa) |
| | fabA | beta-hydroxydecanoyl-ACP dehydrase; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length (By similarity). (171 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase, biosynthetic; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (340 aa) |
| | PA1628 | Probable 3-hydroxyacyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (509 aa) |
| | PA1629 | Probable enoyl-CoA hydratase/isomerase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa) |
| | PA1631 | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (384 aa) |
| | PA1736 | Probable acyl-CoA thiolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the thiolase-like superfamily. Thiolase family. (401 aa) |
| | PA1737 | Probable 3-hydroxyacyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (714 aa) |
| | acnB | Aconitate hydratase 2; Involved in the catabolism of short chain fatty acids (SCFA) via the tricarboxylic acid (TCA)(acetyl degradation route) and probably via the 2-methylcitrate cycle I (propionate degradation route). Catalyzes the reversible isomerization of citrate to isocitrate via cis-aconitate. Catalyzes the hydration of 2-methyl-cis-aconitate to yield (2R,3S)-2-methylisocitrate. The apo form of AcnB functions as a RNA-binding regulatory protein. (869 aa) |
| | lpxH | Conserved hypothetical protein; Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Can functionally complement lpxH deficiency in E.coli. (240 aa) |
| | fabI | NADH-dependent enoyl-ACP reductase; Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism (By similarity); Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. (265 aa) |
| | PA1821 | Probable enoyl-CoA hydratase/isomerase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the enoyl-CoA hydratase/isomerase family. (270 aa) |
| | PA1827 | Probable short-chain dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (253 aa) |
| | acpP2 | Probable acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (79 aa) |
| | PA1887 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (222 aa) |
| | PA1972 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (567 aa) |
| | atoB | acetyl-CoA acetyltransferase; Product name confidence: Class 2 (High similarity to functionally studied protein). (393 aa) |
| | liuE | 3-hydroxy-3-methylglutaryl-CoA lyase; Involved in the L-leucine, isovalerate and acyclic monoterpene catabolism. Catalyzes the cleavage of 3-hydroxy-3- methylglutaryl-CoA (HMG-CoA) to yield acetyl-CoA and acetoacetate. It can also catalyze the cleavage of 3-hydroxy-3-isohexenylglutaryl-CoA (HIHG_CoA) to yield 7-methyl-3-oxooct-6-enoyl-CoA and acetate. (300 aa) |
| | liuD | methylcrotonyl-CoA carboxylase, alpha-subunit (biotin-containing); Class 1: Function experimentally demonstrated in P. aeruginosa. (655 aa) |
| | liuC | Putative 3-methylglutaconyl-CoA hydratase; Class 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene; Belongs to the enoyl-CoA hydratase/isomerase family. (265 aa) |
| | liuB | methylcrotonyl-CoA carboxylase, beta-subunit; Class 1: Function experimentally demonstrated in P. aeruginosa. (535 aa) |
| | liuA | Putative isovaleryl-CoA dehydrogenase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (387 aa) |
| | liuR | Regulator of liu genes; Class 1: Function experimentally demonstrated in P. aeruginosa. (134 aa) |
| | udg | Probable nucleotide sugar dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (453 aa) |
| | galU | UTP--glucose-1-phosphate uridylyltransferase; May play a role in stationary phase survival; Belongs to the UDPGP type 2 family. (279 aa) |
| | clsB | Probable phospholipase; Catalyzes the phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (401 aa) |
| | pslI | PslI; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (367 aa) |
| | ambB | AmbB; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the ATP-dependent AMP-binding enzyme family. (1249 aa) |
| | PA2324 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (419 aa) |
| | PA2325 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (411 aa) |
| | PA2330 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (355 aa) |
| | PA2346 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (411 aa) |
| | PA2347 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (405 aa) |
| | pvdD | Pyoverdine synthetase D; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (2448 aa) |
| | xylL | Cis-1,2-dihydroxycyclohexa-3,4-diene carboxylate dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein). (253 aa) |
| | PA2537 | Probable acyltransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (209 aa) |
| | PA2541 | Probable CDP-alcohol phosphatidyltransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (211 aa) |
| | PA2550 | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (409 aa) |
| | PA2553 | Probable acyl-CoA thiolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the thiolase-like superfamily. Thiolase family. (396 aa) |
| | PA2557 | Probable AMP-binding enzyme; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (564 aa) |
| | pgsA | CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (186 aa) |
| | PA2693 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (166 aa) |
| | PA2767 | Probable enoyl-CoA hydratase/isomerase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the enoyl-CoA hydratase/isomerase family. (322 aa) |
| | PA2794 | Pseudaminidase; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (438 aa) |
| | PA2815 | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (815 aa) |
| | PA2871 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (265 aa) |
| | atuR | Putative repressor of atu genes; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (198 aa) |
| | atuA | Expressed protein with apparent function in citronellol catabolism; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (600 aa) |
| | atuC | geranyl-CoA carboxylase, beta-subunit; Class 1: Function experimentally demonstrated in P. aeruginosa. (538 aa) |
| | atuD | Putative citronellyl-CoA dehydrogenase involved in catabolism of citronellol; Class 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene. (386 aa) |
| | atuE | Putative isohexenylglutaconyl-CoA hydratase; Class 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene. (264 aa) |
| | atuF | geranyl-CoA carboxylase, alpha-subunit (biotin-containing); Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (661 aa) |
| | atuG | Putative short chain dehydrogenase involved in catabolism of citronellol; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (274 aa) |
| | atuH | Putative very-long chain acyl-CoA synthetase; Class 4: Homologs of previously reported genes of unknown function or no similarity to any previously reported sequences. (608 aa) |
| | PA2940 | Probable acyl-CoA thiolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the thiolase-like superfamily. Thiolase family. (379 aa) |
| | fabV | Hypothetical protein; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It can use both crotonyl-CoA and trans-2- decenoyl-ACP. It is able to convert trans-2-enoyl-ACP of different length (C2 to C16) to the corresponding acyl-ACP. Belongs to the TER reductase family. (398 aa) |
| | etfA | Electron transfer flavoprotein alpha-subunit; The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase) (By similarity). (309 aa) |
| | fabF1 | Beta-ketoacyl-acyl carrier protein synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (414 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (78 aa) |
| | fabG | 3-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | fabD | malonyl-CoA-[acyl-carrier-protein] transacylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (312 aa) |
| | plsX | Fatty acid biosynthesis protein PlsX; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (326 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (254 aa) |
| | lpxK | Tetraacyldisaccharide 4*-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (332 aa) |
| | foaB | Fatty-acid oxidation complex beta-subunit; Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed. (391 aa) |
| | faoA | Fatty-acid oxidation complex alpha-subunit; Involved in the aerobic and anaerobic degradation of long- chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate. In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family. (715 aa) |
| | PA3023 | Conserved hypothetical protein; Probably phosphorylates lipids; the in vivo substrate is unknown. (302 aa) |
| | fadH1 | 2,4-dienoyl-CoA reductase FadH1; Product name confidence: Class 2 (High similarity to functionally studied protein). (679 aa) |
| | accD | acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA. (290 aa) |
| | wbpM | Nucleotide sugar epimerase/dehydratase WbpM; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (665 aa) |
| | wbpL | Glycosyltransferase WbpL; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (339 aa) |
| | wbpK | Probable NAD-dependent epimerase/dehydratase WbpK; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (316 aa) |
| | wbpI | UDP-N-acetylglucosamine 2-epimerase WbpI; Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the epimerization of UDP-2,3-diacetamido-2,3- dideoxy-alpha-D-glucuronic acid (UDP-alpha-D-GlcNAc3NAcA) to UDP-2,3- diacetamido-2,3-dideoxy-alpha-D-mannuronic acid (UDP-alpha-D- ManNAc3NAcA). Exhibits high specificity towards the substrate as UDP- alpha-D-GlcNAc, UDP-alpha-D-GlcNAcA (UDP-2-acetamido-2-deoxy-alpha-D- glucuronic acid) and UDP-alpha-D-GlcNAc3NAc (UDP-2,3-diacetamido-2,3- dideoxy-alpha-D-glucose) cannot act as substrates. Belongs to the UDP-N-acetylgluc [...] (354 aa) |
| | wbpH | Probable glycosyltransferase WbpH; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (373 aa) |
| | hisF2 | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity). (251 aa) |
| | hisH2 | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF (By similarity). (202 aa) |
| | wzx | O-antigen translocase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (411 aa) |
| | wzy | B-band O-antigen polymerase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (438 aa) |
| | wbpE | UDP-2-acetamido-2-dideoxy-d-ribo-hex-3-uluronic acid transaminase, wbpE; Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the amination of UDP-2-acetamido-2-deoxy-3-oxo- D-glucuronic acid (UDP-3-oxo-D-GlcNAcA) to UDP-2-acetamido-3-amino-2,3- dideoxy-D-glucuronic acid (UDP-GlcNAc3NA), using L-glutamate as the preferred amine donor; Belongs to the DegT/DnrJ/EryC1 family. (359 aa) |
| | wbpD | UDP-2-acetamido-3-amino-2,3-dideoxy-d-glucuronic acid N-acetyltransferase, WbpD; Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the transfer of an acetyl group to the C-3 amino position of UDP-2-acetamido-3-amino-2,3-dideoxy-alpha-D-glucuronate (UDP-D-GlcNAc3NA); Belongs to the transferase hexapeptide repeat family. (191 aa) |
| | PA3157 | Probable acetyltransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (629 aa) |
| | wbpB | UDP-2-acetamido-2-deoxy-d-glucuronic acid 3-dehydrogenase, WbpB; Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the NAD-dependent oxidation of UDP-N- acetylglucosaminuronic acid (UDP-D-GlcNAcA) to UDP-2-acetamido-2-deoxy- 3-oxo-D-glucuronic acid (UDP-3-oxo-D-GlcNAcA). Cannot use UDP-GlcNAc or UDP-GalNAc as the nucleotide sugar substrate, and can use only poorly UDP-D-glucuronic acid (UDP-GlcA). Undergoes an NAD(+) recycling mechanism using 2-oxoglutarate as an oxidant. (316 aa) |
| | wbpA | UDP-N-acetyl-d-glucosamine 6-Dehydrogenase; Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the C-6 dehydrogenation of UDP-D-GlcNAc to UDP- N-acetylglucosaminuronic acid (UDP-D-GlcNAcA). (436 aa) |
| | wzz | O-antigen chain length regulator; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (348 aa) |
| | PA3219 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (270 aa) |
| | lpxL | Probable lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (312 aa) |
| | PA3267 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (624 aa) |
| | PA3286 | Hypothetical protein; Catalyzes the condensation of octanoyl-CoA, obtained from exogenously supplied fatty acids via beta-oxidation, with malonyl- [acyl-carrier protein], forming 3-oxodecanoyl-[acyl-carrier protein], an intermediate of the fatty acid elongation cycle that can then be extended to supply all of the cellular fatty acid needs. The enzyme thereby shunts fatty acid degradation intermediates from the beta- oxidation pathway into de novo fatty acid biosynthesis. (350 aa) |
| | fadD1 | long-chain-fatty-acid--CoA ligase; Product name confidence: Class 2 (High similarity to functionally studied protein). (562 aa) |
| | PA3302 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (156 aa) |
| | PA3310 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (551 aa) |
| | fabH2 | 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (330 aa) |
| | rfaD | ADP-L-glycero-D-mannoheptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose. (332 aa) |
| | PA3454 | Probable acyl-CoA thiolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the thiolase-like superfamily. Thiolase family. (394 aa) |
| | rhlB | Rhamnosyltransferase chain B; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (426 aa) |
| | rhlA | Rhamnosyltransferase chain A; Required for rhamnolipid surfactant production. Supplies the acyl moieties for rhamnolipid biosynthesis by competing with the enzymes of the type II fatty acid synthase (FASII) cycle for the beta-hydroxyacyl-acyl carrier protein (ACP) pathway intermediates. Catalyzes the formation of one molecule of beta-hydroxydecanoyl-beta-hydroxydecanoate from two molecules of beta- hydroxydecanoyl-ACP. Is the only enzyme required to generate the lipid component of rhamnolipid. In vitro results establish that RhlA is highly selective for 10-carbon acyl-ACP intermediates [...] (295 aa) |
| | pldA | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (1099 aa) |
| | PA3511 | Probable short-chain dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (253 aa) |
| | alg44 | Alginate biosynthesis protein Alg44; Required for alginate biosynthesis. Belongs to the Alg44 family. (389 aa) |
| | arnB | ArnB; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (382 aa) |
| | arnC | ArnC; Catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. (339 aa) |
| | arnA | ArnA; Bifunctional enzyme that catalyzes the oxidative decarboxylation of UDP-glucuronic acid (UDP-GlcUA) to UDP-4-keto- arabinose (UDP-Ara4O) and the addition of a formyl group to UDP-4- amino-4-deoxy-L-arabinose (UDP-L-Ara4N) to form UDP-L-4-formamido- arabinose (UDP-L-Ara4FN). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; In the C-terminal section; belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. (662 aa) |
| | arnD | ArnD; Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the polysaccharide deacetylase family. ArnD deformylase subfamily. (295 aa) |
| | arnT | Inner membrane L-Ara4N transferase ArnT; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (549 aa) |
| | arnE | ArnE; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnE family. (115 aa) |
| | arnF | ArnF; Translocates 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane; Belongs to the ArnF family. (137 aa) |
| | PA3586 | Probable hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (328 aa) |
| | PA3589 | Probable acyl-CoA thiolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the thiolase-like superfamily. Thiolase family. (401 aa) |
| | PA3590 | Probable hydroxyacyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (510 aa) |
| | PA3591 | Probable enoyl-CoA hydratase/isomerase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the enoyl-CoA hydratase/isomerase family. (265 aa) |
| | dgkA | Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (123 aa) |
| | ygbB | 2C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (157 aa) |
| | ygbP | 4-diphosphocytidyl-2-C-methylerythritol synthase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (234 aa) |
| | kdsA | 2-dehydro-3-deoxyphosphooctonate aldolase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the KdsA family. (281 aa) |
| | accA | Acetyl-coenzyme A carboxylase carboxyl transferase (alpha subunit); Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. Belongs to the AccA family. (316 aa) |
| | lpxB | Lipid A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (378 aa) |
| | lpxA | UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (258 aa) |
| | fabZ | (3R)-hydroxymyristoyl-[acyl carrier protein] dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (146 aa) |
| | lpxD | UDP-3-O-[3-hydroxylauroyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (353 aa) |
| | dxr | 1-deoxy-d-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP). (396 aa) |
| | cdsA | Phosphatidate cytidylyltransferase; Product name confidence: Class 2 (High similarity to functionally studied protein). (271 aa) |
| | uppS | Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (251 aa) |
| | plsB | Glycerol-3-phosphate acyltransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the GPAT/DAPAT family. (834 aa) |
| | PA3741 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (141 aa) |
| | gcpE | Probable isoprenoid biosynthetic protein GcpE; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (371 aa) |
| | suhB | Extragenic suppressor protein SuhB; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the inositol monophosphatase superfamily. (271 aa) |
| | PA3853 | Probable transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (229 aa) |
| | pcs | Phosphatidylcholine synthase; Condenses choline with CDP-diglyceride to produce phosphatidylcholine and CMP; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (238 aa) |
| | PA3925 | Probable acyl-CoA thiolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the thiolase-like superfamily. Thiolase family. (391 aa) |
| | tesB | acyl-CoA thioesterase II; Product name confidence: Class 2 (High similarity to functionally studied protein). (289 aa) |
| | PA3958 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (379 aa) |
| | lis | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (327 aa) |
| | ispA | Geranyltranstransferase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the FPP/GGPP synthase family. (295 aa) |
| | pgpA | Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (171 aa) |
| | PA4069 | Hypothetical protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (294 aa) |
| | pchF | Pyochelin synthetase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (1809 aa) |
| | PA4338 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (426 aa) |
| | PA4339 | Probable phospholipase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (359 aa) |
| | PA4351 | Probable acyltransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (258 aa) |
| | PA4353 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (190 aa) |
| | speA | Probable short-chain dehydrogenase; Product name confidence: Class 3: Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene. (252 aa) |
| | lpxC | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (303 aa) |
| | murG | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (357 aa) |
| | gmhA | Sedoheptulose 7-phosphate isomerase GmhA; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (197 aa) |
| | PA4435 | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (381 aa) |
| | kdsD | Arabinose-5-phosphate isomerase KdsD; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). (326 aa) |
| | PA4458 | Conserved hypothetical protein; Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8- phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate; Belongs to the KdsC family. (179 aa) |
| | PA4517 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (600 aa) |
| | lytB | LytB protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (314 aa) |
| | ispB | Octaprenyl-diphosphate synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the FPP/GGPP synthase family. (322 aa) |
| | pagL | Lipid A 3-O-deacylase; Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety. Lacks fatty acyl chain-length specificity as removes both 3-OH C10 and 3-OH C14 fatty acids from lipid A. (173 aa) |
| | ipk | Isopentenyl monophosphate kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (282 aa) |
| | pssA | Phosphatidylserine synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (271 aa) |
| | PA4786 | Probable short-chain dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (451 aa) |
| | PA4788 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (285 aa) |
| | fadH2 | 2,4-dienoyl-CoA reductase FadH2; Product name confidence: Class 2 (High similarity to functionally studied protein). (681 aa) |
| | PA4818 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (478 aa) |
| | PA4841 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (178 aa) |
| | accB | Biotin carboxyl carrier protein (BCCP); This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (156 aa) |
| | accC | Biotin carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (449 aa) |
| | PA4872 | Hypothetical protein; Catalyzes the decarboxylation of oxaloacetate into pyruvate with high efficiency. Is also able to decarboxylate 3- methyloxaloacetate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate. Belongs to the isocitrate lyase/PEP mutase superfamily. Oxaloacetate decarboxylase family. (287 aa) |
| | PA4907 | Probable short-chain dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (253 aa) |
| | psd | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (289 aa) |
| | PA4980 | Probable enoyl-CoA hydratase/isomerase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the enoyl-CoA hydratase/isomerase family. (263 aa) |
| | PA4986 | Probable oxidoreductase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (648 aa) |
| | waaA | 3-deoxy-D-manno-octulosonic-acid (KDO) transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa) |
| | PA4994 | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (402 aa) |
| | PA4995 | Probable acyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (429 aa) |
| | rfaE | LPS biosynthesis protein RfaE; Catalyzes the phosphorylation of D-glycero-D-manno-heptose 7- phosphate at the C-1 position to selectively form D-glycero-beta-D- manno-heptose-1,7-bisphosphate; In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (474 aa) |
| | msbA | Transport protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (603 aa) |
| | waaL | O-antigen ligase, WaaL; Potential O-antigen polymerase, which may be involved in the synthesis of LPS. (401 aa) |
| | wapR | Alpha-1,3-rhamnosyltransferase WapR; Class 1: Function experimentally demonstrated in P. aeruginosa. (294 aa) |
| | PA5001 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (318 aa) |
| | PA5002 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (472 aa) |
| | PA5003 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (298 aa) |
| | PA5008 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (244 aa) |
| | waaP | Lipopolysaccharide kinase WaaP; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core. The phosphorylation of the lipopolysaccharide core seems to occur prior to translocation to the periplasm and attachment of O-antigen. Also has protein-tyrosine kinase activity: autophosphorylates on all Tyr residues; in vitro can phosphorylate poly(Glu,Tyr). (268 aa) |
| | waaG | UDP-glucose:(heptosyl) LPS alpha 1,3-glucosyltransferase WaaG; Product name confidence: Class 2 (High similarity to functionally studied protein). (373 aa) |
| | waaC | Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (355 aa) |
| | waaF | Heptosyltransferase II; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (345 aa) |
| | phaD | Poly(3-hydroxyalkanoic acid) depolymerase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (285 aa) |
| | PA5089 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (745 aa) |
| | estA | Esterase EstA; Esterase whose enzymatic activity is required for rhamnolipid production, all kinds of cell motility (swimming, swarming, and twitching), and biofilm formation; the exact role of EstA in these processes is unclear. In vitro, has pronounced esterase activities towards p-nitrophenyl esters of short acyl chain length (C4-C6) and Tween detergents. Also shows relatively high activity towards beta- naphthyl butyrate, whereas its activities towards triacylglycerols and acyls-CoA are negligible. (646 aa) |
| | rmlB | dTDP-D-glucose 4,6-dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. (352 aa) |
| | rmlD | dTDP-4-dehydrorhamnose reductase; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (302 aa) |
| | rmlA | Glucose-1-phosphate thymidylyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. Belongs to the glucose-1-phosphate thymidylyltransferase family. (293 aa) |
| | rmlC | dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. (181 aa) |
| | fabY | Probable beta-ketoacyl synthase; Involved in the initiation of the fatty acid biosynthesis. Catalyzes the condensation of acetyl coenzyme A (acetyl-CoA) with malonyl-acyl carrier protein (ACP) to make the fatty acid synthesis (FAS) primer beta-acetoacetyl-ACP. It can also use short-chain acyl-CoA as substrates, including butyryl-CoA, and hexanoyl-CoA, but does not use any of the longer chain acyl-CoA substrates. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (634 aa) |
| | PA5188 | Probable 3-hydroxyacyl-CoA dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (411 aa) |
| | PA5238 | Probable O-antigen acetylase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (662 aa) |
| | ppx | Exopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has also polyphosphate:ADP phosphotransferase activity, catalyzing the production of ATP from ADP and polyP. (506 aa) |
| | PA5310 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (529 aa) |
| | algC | Phosphomannomutase AlgC; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity. Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enzyme-phospho-Ser-1 [...] (463 aa) |
| | PA5324 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (356 aa) |
| | PA5325 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (316 aa) |
| | PA5326 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (402 aa) |
| | PA5327 | Probable oxidoreductase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (442 aa) |
| | PA5328 | Probable cytochrome c(mono-heme type); Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (129 aa) |
| | PA5371 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (134 aa) |
| | cdhA | CdhA, Carnitine dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3- dehydrocarnitine. Is specific for L-carnitine and NAD(+) as substrates. D,L-3-hydroxybutyrate, L-lactate, ethanol, L-malate and D,L-isocitrate are not substrates. Is involved in a L-carnitine degradation pathway that allows P.aeruginosa to grow on L-carnitine as the sole source of carbon and nitrogen. (321 aa) |
| | cls | Cardiolipin synthase; Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol. (490 aa) |
| | PA5400 | Probable electron transfer flavoprotein alpha subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (328 aa) |
| | PA5436 | Probable biotin carboxylase subunit of a transcarboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (471 aa) |
| | PA5445 | Probable coenzyme A transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (497 aa) |
| | wbpZ | Glycosyltransferase WbpZ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (381 aa) |
| | wbpY | Glycosyltransferase WbpY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (375 aa) |
| | wbpX | Glycosyltransferase WbpX; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (460 aa) |
| | wzt | ABC subunit of A-band LPS efflux transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (421 aa) |
| | wzm | Membrane subunit of A-band LPS efflux transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (265 aa) |
| | wbpW | Phosphomannose isomerase/GDP-mannose WbpW; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the mannose-6-phosphate isomerase type 2 family. (479 aa) |
| | gmd | GDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (323 aa) |
| | rmd | Oxidoreductase Rmd; Reductase that catalyzes the conversion of GDP-6-deoxy-D- mannose to GDP-4-dehydro-6-deoxy-D-mannose (GDP-D-rhamnose). (304 aa) |
| | PA5455 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (542 aa) |
| | PA5456 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (433 aa) |
| | PA5457 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (287 aa) |
| | PA5458 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (380 aa) |
| | PA5459 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (278 aa) |
| | PA5488 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (292 aa) |
| | PA5519 | Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (188 aa) |
| | PA5521 | Probable short-chain dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (252 aa) |
| | PA5524 | Probable short-chain dehydrogenase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (260 aa) |
| | glmU | Glucosamine-1-phosphate acetyltransferase/N-acetylglucosamine-1-phosphate uridyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to t [...] (454 aa) |
