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fabY fabY pvdQ pvdQ pvdA pvdA pvdR pvdR pvdT pvdT opmQ opmQ pvdP pvdP PA2393 PA2393 pvdN pvdN pvdO pvdO pvdF pvdF pvdE pvdE fpvA fpvA pchB pchB pvdJ pvdJ pvdD pvdD pchA pchA PA3109 PA3109 pqsH pqsH pvdG pvdG pvdL pvdL pvdH pvdH PA2412 PA2412 PA2403 PA2403 PA2402 PA2402 fur fur prtN prtN prtR prtR pqsA pqsA pqsB pqsB pqsC pqsC pqsD pqsD pqsE pqsE pcpS pcpS ccmC ccmC ccmF ccmF pvcC pvcC ambE ambE pchC pchC pchF pchF PA3327 PA3327
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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experimentally determined
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gene neighborhood
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Your Input:
fabYProbable beta-ketoacyl synthase; Involved in the initiation of the fatty acid biosynthesis. Catalyzes the condensation of acetyl coenzyme A (acetyl-CoA) with malonyl-acyl carrier protein (ACP) to make the fatty acid synthesis (FAS) primer beta-acetoacetyl-ACP. It can also use short-chain acyl-CoA as substrates, including butyryl-CoA, and hexanoyl-CoA, but does not use any of the longer chain acyl-CoA substrates. Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. (634 aa)
pvdQ3-oxo-C12-homoserine lactone acylase PvdQ; Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo- C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum- sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be requ [...] (762 aa)
pvdAL-ornithine N5-oxygenase; Catalyzes the conversion of L-ornithine to N(5)- hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores, such as pyoverdin. Pyoverdin is a hydroxamate siderophore composed of a 6,7-dihydroxyquinoline-containing fluorescent chromophore joined to the N-terminus of a partly cyclic octapeptide (D-Ser-L-Arg-D-Ser-L-N(5)-OH-Orn-L-Lys-L-N(5)-OH-Orn-L-Thr- L-Thr in strain PAO1). Specific for NADPH, which plays a role in stabilization of the C4a-hydroperoxyflavin intermediate. (443 aa)
pvdRPvdR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (391 aa)
pvdTPvdT; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (663 aa)
opmQProbable outer membrane protein precursor; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (474 aa)
pvdPPvdP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (544 aa)
PA2393Probable dipeptidase precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (448 aa)
pvdNPvdN; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (427 aa)
pvdOPvdO; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (284 aa)
pvdFPyoverdine synthetase F; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (275 aa)
pvdEPyoverdine biosynthesis protein PvdE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (549 aa)
fpvAFerripyoverdine receptor; Receptor for the siderophore ferripyoverdine. (815 aa)
pchBSalicylate biosynthesis protein PchB; Involved in the incorporation of salicylate into the siderophore pyochelin. Catalyzes the elimination of the enolpyruvyl side chain from isochorismate to yield salicylate and pyruvate via a rare pericyclic hydrogen transfer mechanism from C2 to C5. PchB also catalyzes the nonphysiological Claisen rearrangement of chorismate to prephenate in which the pyruvylenol tail is transferred from a C3 ether linkage to a C1-C9 linkage. (101 aa)
pvdJPvdJ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (2157 aa)
pvdDPyoverdine synthetase D; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (2448 aa)
pchASalicylate biosynthesis isochorismate synthase; Involved in the conversion of chorismate to salicylate. (476 aa)
PA3109Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (180 aa)
pqsHProbable FAD-dependent monooxygenase; Involved in the terminal step of the biosynthesis of quinolone which in addition to serve as a potent signal for quorum sensing, chelates iron and promotes the formation of membrane vesicles (MVs). Catalyzes the hydroxylation of 2-heptyl-4-quinolone (C7-HHQ) to yield 2-heptyl-3-hydroxy-4-quinolone (PQS). Belongs to the 3-hydroxybenzoate 6-hydroxylase family. (382 aa)
pvdGPvdG; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (254 aa)
pvdLPvdL; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (4342 aa)
pvdHL-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase, PvdH; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (469 aa)
PA2412Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (72 aa)
PA2403Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (403 aa)
PA2402Probable non-ribosomal peptide synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (5149 aa)
furFerric uptake regulation protein; Fur acts as a repressor, employing Fe(2+) as a cofactor to bind the operator of the iron transport operon. Involved in exotoxin A regulation, siderophore regulation and manganese susceptibility. (134 aa)
prtNTranscriptional regulator PrtN; Activates pyocin genes, probably by binding to the sequences conserved in their 5' non-coding regions (P box). (104 aa)
prtRTranscriptional regulator PrtR; Represses the promoter activity of the prtN gene. (256 aa)
pqsAProbable coenzyme A ligase; Catalyzes the formation of anthraniloyl-CoA, which is the priming step for entry into the Pseudomonas quinolone signal (PQS) biosynthetic pathway. Also active on a variety of aromatic substrates, including benzoate and chloro and fluoro derivatives of anthranilate. (517 aa)
pqsBPqsB; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. PqsB, together with PqsC, catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and resulting in closure of the quinoline ring. PqsB is probably required for the proper folding of PqsC ra [...] (283 aa)
pqsCPqsC; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. First, PqsC acquires an octanoyl group from octanoyl-CoA and forms an octanoyl-PqsC intermediate. Then, together with PqsB, it catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and re [...] (348 aa)
pqsD3-oxoacyl-[acyl-carrier-protein] synthase III; Required for the biosynthesis of a number of signaling molecules, such as the quinolone signal 2-heptyl-3-hydroxy-4(1H)- quinolone (PQS), 2-heptyl-4-hydroxyquinoline (HHQ) and 2,4- dihydroxyquinoline (DHQ). These molecules are required for normal biofilm formation. Catalyzes the transfer of the anthraniloyl moiety from anthraniloyl-CoA to malonyl-CoA to form 2-aminobenzoylacetyl-CoA. The first step of the reaction is the formation of a covalent anthraniloyl-PqsD intermediate. Next, the short-lived intermediate 3-(2-aminophenyl)- 3-oxopropa [...] (337 aa)
pqsEQuinolone signal response protein; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2- aminobenzoylacetate (2-ABA), the precursor of HHQ. In vitro, can also hydrolyze other substrates such as S-ethyl-acetothioacetate and acetoacetyl-CoA, but is inactive against anthraniloyl-CoA, malonyl-CoA and octanoyl-CoA. Be [...] (301 aa)
pcpSPcpS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the P-Pant transferase superfamily. (242 aa)
ccmCHeme exporter protein CcmC; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (252 aa)
ccmFCytochrome C-type biogenesis protein CcmF; Required for the biogenesis of c-type cytochromes. Possible subunit of a heme lyase (By similarity); Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family. (657 aa)
pvcCPaerucumarin biosynthesis protein PvcC; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (500 aa)
ambEAmbE; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (2124 aa)
pchCPyochelin biosynthetic protein PchC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (251 aa)
pchFPyochelin synthetase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (1809 aa)
PA3327Probable non-ribosomal peptide synthetase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (2352 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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