8 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PA3517	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
	aspA	Aspartate ammonia-lyase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II fumarase/aspartase family. Aspartase subfamily. (474 aa)
	argH	Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein). (464 aa)
	fumC1	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (458 aa)
	pcaB	3-carboxy-cis,cis-muconate cycloisomerase; Catalyzes an anti cycloisomerization. (459 aa)
	fumC2	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
	purB	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein). (456 aa)
	PA3516	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (483 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PA3516	PA3517	PA3516	PA3517	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.997
PA3516	argH	PA3516	PA5263	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.913
PA3516	aspA	PA3516	PA5429	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Aspartate ammonia-lyase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.	0.905
PA3516	purB	PA3516	PA2629	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.900
PA3517	PA3516	PA3517	PA3516	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.997
PA3517	argH	PA3517	PA5263	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.913
PA3517	aspA	PA3517	PA5429	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Aspartate ammonia-lyase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.	0.905
PA3517	purB	PA3517	PA2629	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.900
argH	PA3516	PA5263	PA3516	Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.913
argH	PA3517	PA5263	PA3517	Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.913
argH	aspA	PA5263	PA5429	Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Aspartate ammonia-lyase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.	0.922
argH	fumC1	PA5263	PA4470	Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.828
argH	fumC2	PA5263	PA0854	Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.827
argH	purB	PA5263	PA2629	Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.914
aspA	PA3516	PA5429	PA3516	Aspartate ammonia-lyase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.905
aspA	PA3517	PA5429	PA3517	Aspartate ammonia-lyase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.	Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.	0.905
aspA	argH	PA5429	PA5263	Aspartate ammonia-lyase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.	Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.922
aspA	purB	PA5429	PA2629	Aspartate ammonia-lyase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the class-II fumarase/aspartase family. Aspartase subfamily.	Adenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.910
fumC1	argH	PA4470	PA5263	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	Argininosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.828
fumC1	fumC2	PA4470	PA0854	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.907