13 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

co-expression

protein homology

Your Input:
	toxA	Exotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38. (638 aa)
	exoT	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (457 aa)
	rnc	Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (229 aa)
	PA0906	Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (237 aa)
	PA1520	Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (259 aa)
	exoY	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (378 aa)
	tse2	Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the cytoplasm of recipient cells. Acts likely as a NAD-dependent cytotoxin towards both prokaryotic and eukaryotic cells. (158 aa)
	ppiA	Peptidyl-prolyl cis-trans isomerase A; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction. (187 aa)
	ldh	Leucine dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (341 aa)
	exoS	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (453 aa)
	PA3853	Probable transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (229 aa)
	PA4339	Probable phospholipase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (359 aa)
	rho	Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PA0906	PA1520	PA0906	PA1520	Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.892
PA0906	rnc	PA0906	PA0770	Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.	0.499
PA0906	tse2	PA0906	PA2702	Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the cytoplasm of recipient cells. Acts likely as a NAD-dependent cytotoxin towards both prokaryotic and eukaryotic cells.	0.412
PA1520	PA0906	PA1520	PA0906	Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.892
PA1520	rnc	PA1520	PA0770	Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.	0.429
exoS	exoT	PA3841	PA0044	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.907
exoS	exoY	PA3841	PA2191	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.959
exoS	ldh	PA3841	PA3418	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Leucine dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.809
exoS	ppiA	PA3841	PA3227	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Peptidyl-prolyl cis-trans isomerase A; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction.	0.634
exoS	rho	PA3841	PA5239	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.	0.806
exoS	toxA	PA3841	PA1148	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Exotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38.	0.883
exoT	exoS	PA0044	PA3841	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.907
exoT	exoY	PA0044	PA2191	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.964
exoT	ldh	PA0044	PA3418	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Leucine dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.700
exoT	ppiA	PA0044	PA3227	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Peptidyl-prolyl cis-trans isomerase A; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. This protein is not essential for growth. Presumably plays a role in signal transduction.	0.565
exoT	rho	PA0044	PA5239	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.	0.769
exoT	toxA	PA0044	PA1148	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Exotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38.	0.883
exoY	exoS	PA2191	PA3841	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.959
exoY	exoT	PA2191	PA0044	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.964
exoY	ldh	PA2191	PA3418	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Leucine dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.	0.591