33 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	retS	RetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
	exoT	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (457 aa)
	vfr	Transcriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production. (214 aa)
	PA0657	Probable ATPase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (493 aa)
	mucA	Anti-sigma factor MucA; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucA causes a switch from the non-mucoid to mucoid state resulting in constitutive expression of alginate biosynthetic genes. (194 aa)
	gacS	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). (925 aa)
	fliC	Flagellin type B; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (488 aa)
	pscP	Translocation protein in type III secretion; Product name confidence: Class 2 (High similarity to functionally studied protein). (369 aa)
	pcrH	Regulatory protein PcrH; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (167 aa)
	popB	Translocator protein PopB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (390 aa)
	popD	Translocator outer membrane protein PopD precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (295 aa)
	exsC	ExsC, exoenzyme S synthesis protein C precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (145 aa)
	exsE	ExsE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (81 aa)
	exsA	Transcriptional regulator ExsA; Appears to be required for induction of exoenzyme S synthesis above a low basal level. (278 aa)
	exsD	ExsD; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (276 aa)
	pscC	Type III secretion outer membrane protein PscC precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (600 aa)
	pscE	Type III export protein PscE; Prevents premature polymerization of PscF, along with PscG, within the cytoplasm. Required for type III secretion needle assembly. Also required for cytotoxicity by influencing PscF levels. Belongs to the YscE family. (67 aa)
	pscF	Type III export protein PscF; Major component of the type III secretion needle structure. Required for cytotoxicity on macrophages. (85 aa)
	pscG	Type III export protein PscG; Prevents premature polymerization of PscF, along with PscE, within the cytoplasm. Required for type III secretion needle assembly. Also required for cytotoxicity by influencing PscF levels. (115 aa)
	pscJ	Type III export protein PscJ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (248 aa)
	pscL	Type III export protein PscL; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (214 aa)
	exoY	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (378 aa)
	xylS	Transcriptional regulator XylS; Product name confidence: Class 2 (High similarity to functionally studied protein). (318 aa)
	gacA	Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. (214 aa)
	gltR	Two-component response regulator GltR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (242 aa)
	cyaB	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (463 aa)
	exoS	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (453 aa)
	ladS	Lost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (795 aa)
	PA4339	Probable phospholipase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (359 aa)
	sodB	Superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (193 aa)
	sodM	Superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (203 aa)
	rho	Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (419 aa)
	cyaA	Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). (950 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cyaA	cyaB	PA5272	PA3217	Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein).	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.989
cyaA	exoY	PA5272	PA2191	Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.885
cyaA	exsA	PA5272	PA1713	Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Transcriptional regulator ExsA; Appears to be required for induction of exoenzyme S synthesis above a low basal level.	0.418
cyaA	mucA	PA5272	PA0763	Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Anti-sigma factor MucA; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucA causes a switch from the non-mucoid to mucoid state resulting in constitutive expression of alginate biosynthetic genes.	0.458
cyaA	vfr	PA5272	PA0652	Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein).	Transcriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production.	0.947
cyaB	cyaA	PA3217	PA5272	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.989
cyaB	exsA	PA3217	PA1713	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Transcriptional regulator ExsA; Appears to be required for induction of exoenzyme S synthesis above a low basal level.	0.595
cyaB	gacS	PA3217	PA0928	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.710
cyaB	mucA	PA3217	PA0763	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Anti-sigma factor MucA; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucA causes a switch from the non-mucoid to mucoid state resulting in constitutive expression of alginate biosynthetic genes.	0.412
cyaB	retS	PA3217	PA4856	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	RetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.425
cyaB	vfr	PA3217	PA0652	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Transcriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production.	0.995
exoS	exoT	PA3841	PA0044	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.907
exoS	exoY	PA3841	PA2191	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.959
exoS	exsA	PA3841	PA1713	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Transcriptional regulator ExsA; Appears to be required for induction of exoenzyme S synthesis above a low basal level.	0.936
exoS	exsC	PA3841	PA1710	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	ExsC, exoenzyme S synthesis protein C precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.957
exoS	exsD	PA3841	PA1714	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	ExsD; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.945
exoS	exsE	PA3841	PA1711	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	ExsE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.859
exoS	fliC	PA3841	PA1092	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Flagellin type B; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella.	0.880
exoS	gacA	PA3841	PA2586	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.	0.598
exoS	gacS	PA3841	PA0928	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.587