STRINGSTRING
rocA1 rocA1 ladS ladS bfmR bfmR bfmS bfmS bfiS bfiS mvaT mvaT bifA bifA pilR pilR cbrB cbrB retS retS ntrC ntrC algB algB mifR mifR mifS mifS bfiR bfiR rpoD rpoD PA0657 PA0657 gacS gacS fleQ fleQ fleR fleR lasR lasR cheY cheY qscR qscR PA2096 PA2096 gacA gacA PA2990 PA2990 rhlR rhlR guaA guaA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rocA1Two-component response regulator RocA1; Class 1: Function experimentally demonstrated in P. aeruginosa. (209 aa)
ladSLost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (795 aa)
bfmRBfmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (246 aa)
bfmSBfmS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (434 aa)
bfiSBfiS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (758 aa)
mvaTTranscriptional regulator MvaT, P16 subunit; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (124 aa)
bifABifA; Class 1: Function experimentally demonstrated in P. aeruginosa. (687 aa)
pilRTwo-component response regulator PilR; Member of the two-component regulatory system PilS/PilR that regulates the expression of type 4 fimbriae. When activated by PilS it acts in conjunction with sigma-54 as a transcriptional activator. (445 aa)
cbrBTwo-component response regulator CbrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (478 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
ntrCTwo-component response regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (476 aa)
algBTwo-component response regulator AlgB; Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. Positive regulator of the alginate biosynthetic gene AlgD. (449 aa)
mifRMifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (447 aa)
mifSMifS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (588 aa)
bfiRBfiR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (214 aa)
rpoDSigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (617 aa)
PA0657Probable ATPase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (493 aa)
gacSSensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). (925 aa)
fleQTranscriptional regulator FleQ; AAA+ ATPase enhancer-binding protein that acts as a transcription regulator and plays a role in the modulation of mucin adhesion and flagellar gene expression. In addition to flagella genes, regulates also expression of biofilm-related genes. Functions as a transcriptional repressor in the absence of c-di-GMP and as an activator when c-di-GMP is present. (490 aa)
fleRTwo-component response regulator; Plays a role in the regulation of both flagellar synthesis and adhesion to mucin. (473 aa)
lasRTranscriptional regulator LasR; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer; Belongs to the autoinducer-regulated transcriptional regulatory protein family. (239 aa)
cheYTwo-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation. (124 aa)
qscRQuorum-sensing control repressor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (237 aa)
PA2096Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (344 aa)
gacAResponse regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. (214 aa)
PA2990Probable phosphodiesterase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (240 aa)
rhlRTranscriptional regulator RhlR; Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone). (241 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (525 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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