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xcpW xcpW xcpS xcpS rhlR rhlR rhlA rhlA PA3718 PA3718 rhl rhl narG narG narL narL mexG mexG mexH mexH mexI mexI opmD opmD phzA1 phzA1 fptA fptA pchF pchF pchE pchE pchR pchR pchD pchD pchC pchC pchB pchB pchA pchA tadC tadC tadZ tadZ desT desT hfq hfq chiC chiC ahpF ahpF PA0236 PA0236 pqsA pqsA pqsB pqsB pqsC pqsC pqsD pqsD pqsE pqsE mvfR mvfR fliE fliE fliI fliI PA1196 PA1196 aprD aprD lasR lasR rsaL rsaL lasI lasI flhA flhA phzA2 phzA2 phzC2 phzC2 phzE2 phzE2 cupA1 cupA1 katE katE soxR soxR PA2274 PA2274 pvdH pvdH catA catA catC catC catB catB xylS xylS lecA lecA pqsH pqsH xcpZ xcpZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
xcpWGeneral secretion pathway protein J; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity). Required for the translocation of a variety of enzymes across the outer membrane. (237 aa)
xcpSGeneral secretion pathway protein F; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. Required for the translocation of a variety of enzymes across the outer membrane. (405 aa)
rhlRTranscriptional regulator RhlR; Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone). (241 aa)
rhlARhamnosyltransferase chain A; Required for rhamnolipid surfactant production. Supplies the acyl moieties for rhamnolipid biosynthesis by competing with the enzymes of the type II fatty acid synthase (FASII) cycle for the beta-hydroxyacyl-acyl carrier protein (ACP) pathway intermediates. Catalyzes the formation of one molecule of beta-hydroxydecanoyl-beta-hydroxydecanoate from two molecules of beta- hydroxydecanoyl-ACP. Is the only enzyme required to generate the lipid component of rhamnolipid. In vitro results establish that RhlA is highly selective for 10-carbon acyl-ACP intermediates [...] (295 aa)
PA3718Probable major facilitator superfamily (MFS) transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (413 aa)
rhlATP-dependent RNA helicase RhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (397 aa)
narGRespiratory nitrate reductase alpha chain; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1261 aa)
narLTwo-component response regulator NarL; Product name confidence: Class 2 (High similarity to functionally studied protein). (219 aa)
mexGHypothetical protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (148 aa)
mexHProbable Resistance-Nodulation-Cell Division (RND) efflux membrane fusion protein precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (370 aa)
mexIProbable Resistance-Nodulation-Cell Division (RND) efflux transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1029 aa)
opmDProbable outer membrane protein precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (487 aa)
phzA1Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzA1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. (162 aa)
fptAFe(III)-pyochelin outer membrane receptor precursor; High-affinity outer membrane receptor required for the transport of Fe(3+)-pyochelin. (720 aa)
pchFPyochelin synthetase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (1809 aa)
pchEDihydroaeruginoic acid synthetase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (1438 aa)
pchRTranscriptional regulator PchR; Positive activator of the genes for pyochelin and ferripyochelin receptors. (296 aa)
pchDPyochelin biosynthesis protein PchD; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (547 aa)
pchCPyochelin biosynthetic protein PchC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (251 aa)
pchBSalicylate biosynthesis protein PchB; Involved in the incorporation of salicylate into the siderophore pyochelin. Catalyzes the elimination of the enolpyruvyl side chain from isochorismate to yield salicylate and pyruvate via a rare pericyclic hydrogen transfer mechanism from C2 to C5. PchB also catalyzes the nonphysiological Claisen rearrangement of chorismate to prephenate in which the pyruvylenol tail is transferred from a C3 ether linkage to a C1-C9 linkage. (101 aa)
pchASalicylate biosynthesis isochorismate synthase; Involved in the conversion of chorismate to salicylate. (476 aa)
tadCTadC; Class 2: Function of highly similar gene experimentally demonstrated in another organism (and gene context consistent in terms of pathways its involved in (if known). (303 aa)
tadZTadZ; Class 2: Function of highly similar gene experimentally demonstrated in another organism (and gene context consistent in terms of pathways its involved in (if known). (394 aa)
desTDesT; Class 1: Function experimentally demonstrated in P. aeruginosa. (209 aa)
hfqHfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (82 aa)
chiCChitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family. (483 aa)
ahpFAlkyl hydroperoxide reductase subunit F; Serves to protect the cell against DNA damage by alkyl hydroperoxides. It can use either NADH or NADPH as electron donor for direct reduction of redox dyes or of alkyl hydroperoxides when combined with the AhpC protein (By similarity); Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. (521 aa)
PA0236Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (259 aa)
pqsAProbable coenzyme A ligase; Catalyzes the formation of anthraniloyl-CoA, which is the priming step for entry into the Pseudomonas quinolone signal (PQS) biosynthetic pathway. Also active on a variety of aromatic substrates, including benzoate and chloro and fluoro derivatives of anthranilate. (517 aa)
pqsBPqsB; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. PqsB, together with PqsC, catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and resulting in closure of the quinoline ring. PqsB is probably required for the proper folding of PqsC ra [...] (283 aa)
pqsCPqsC; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. First, PqsC acquires an octanoyl group from octanoyl-CoA and forms an octanoyl-PqsC intermediate. Then, together with PqsB, it catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and re [...] (348 aa)
pqsD3-oxoacyl-[acyl-carrier-protein] synthase III; Required for the biosynthesis of a number of signaling molecules, such as the quinolone signal 2-heptyl-3-hydroxy-4(1H)- quinolone (PQS), 2-heptyl-4-hydroxyquinoline (HHQ) and 2,4- dihydroxyquinoline (DHQ). These molecules are required for normal biofilm formation. Catalyzes the transfer of the anthraniloyl moiety from anthraniloyl-CoA to malonyl-CoA to form 2-aminobenzoylacetyl-CoA. The first step of the reaction is the formation of a covalent anthraniloyl-PqsD intermediate. Next, the short-lived intermediate 3-(2-aminophenyl)- 3-oxopropa [...] (337 aa)
pqsEQuinolone signal response protein; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2- aminobenzoylacetate (2-ABA), the precursor of HHQ. In vitro, can also hydrolyze other substrates such as S-ethyl-acetothioacetate and acetoacetyl-CoA, but is inactive against anthraniloyl-CoA, malonyl-CoA and octanoyl-CoA. Be [...] (301 aa)
mvfRTranscriptional regulator MvfR; Transcription regulator that plays a critical role in virulence by positively regulating the expression of multiple quorum sensing (QS)-regulated virulence factors, genes involved in protein secretion, translation, response to oxidative stress and the phnAB operon. At the stationary phase, negatively autoregulates its function through cleavage and translocation to the extracellular space ; Belongs to the LysR transcriptional regulatory family. (332 aa)
fliEFlagellar hook-basal body complex protein FliE; Product name confidence: Class 2 (High similarity to functionally studied protein). (109 aa)
fliIFlagellum-specific ATP synthase FliI; Probable catalytic subunit of a protein translocase for flagellum-specific export, or a proton translocase involved in local circuits at the flagellum. (451 aa)
PA1196Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (466 aa)
aprDAlkaline protease secretion protein AprD; Involved in the secretion of alkaline protease; Belongs to the ABC transporter superfamily. Alkaline protease exporter (TC 3.A.1.110.4) family. (593 aa)
lasRTranscriptional regulator LasR; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer; Belongs to the autoinducer-regulated transcriptional regulatory protein family. (239 aa)
rsaLRegulatory protein RsaL; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (80 aa)
lasIAutoinducer synthesis protein LasI; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation. (201 aa)
flhAFlagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (707 aa)
phzA2Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzA2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development. (162 aa)
phzC2Phenazine biosynthesis protein PhzC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (405 aa)
phzE2Phenazine biosynthesis protein PhzE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (627 aa)
cupA1Fimbrial subunit CupA1; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (183 aa)
katECatalase HPII; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. HPII subfamily. (709 aa)
soxRSoxR; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron- sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity). (156 aa)
PA2274Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (125 aa)
pvdHL-2,4-diaminobutyrate:2-ketoglutarate 4-aminotransferase, PvdH; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (469 aa)
catACatechol 1,2-dioxygenase; Product name confidence: Class 2 (High similarity to functionally studied protein). (310 aa)
catCMuconolactone delta-isomerase; Product name confidence: Class 2 (High similarity to functionally studied protein). (96 aa)
catBMuconate cycloisomerase I; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the mandelate racemase/muconate lactonizing enzyme family. (373 aa)
xylSTranscriptional regulator XylS; Product name confidence: Class 2 (High similarity to functionally studied protein). (318 aa)
lecALecA; D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl- beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity; Belongs to the LecA/PllA lectin family. (122 aa)
pqsHProbable FAD-dependent monooxygenase; Involved in the terminal step of the biosynthesis of quinolone which in addition to serve as a potent signal for quorum sensing, chelates iron and promotes the formation of membrane vesicles (MVs). Catalyzes the hydroxylation of 2-heptyl-4-quinolone (C7-HHQ) to yield 2-heptyl-3-hydroxy-4-quinolone (PQS). Belongs to the 3-hydroxybenzoate 6-hydroxylase family. (382 aa)
xcpZGeneral secretion pathway protein M; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (174 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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