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lolD lolD ppkA ppkA pppA pppA fha1 fha1 hcp1 hcp1 clpV1 clpV1 vgrG1 vgrG1 ftsE ftsE braD braD braB braB tse1 tse1 tse2 tse2 tsi2 tsi2 xcpY xcpY rcsF rcsF tse3 tse3 ladS ladS lspA lspA retS retS phoR phoR dsbA dsbA
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lolDProbable ATP-binding component of ABC transporter; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner. (227 aa)
ppkASerine/threonine protein kinase PpkA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (1032 aa)
pppAPppA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (242 aa)
fha1Fha1; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (497 aa)
hcp1Hcp1; Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients; Belongs to the hcp1 family. (162 aa)
clpV1ClpV1; Required for secretion of hcp1 probably by providing the energy source for its translocation; Belongs to the ClpA/ClpB family. (902 aa)
vgrG1VgrG1; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1. Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity. (643 aa)
ftsECell division protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (223 aa)
braDBranched-chain amino acid transport protein BraD; Component of the high affinity leucine, isoleucine, valine, transport system (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids; Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily. (307 aa)
braBBranched chain amino acid transporter; Component of the LIV-II transport system for branched-chain amino acids. BraB is specific for isoleucine, leucine and valine. The LIV-II transport system is coupled to sodium and lithium ions. (437 aa)
tse1Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin. (154 aa)
tse2Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the cytoplasm of recipient cells. Acts likely as a NAD-dependent cytotoxin towards both prokaryotic and eukaryotic cells. (158 aa)
tsi2Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse2. Binds to a large surface of Tse2 and thereby occludes the active site to specifically inhibits Tse2. (77 aa)
xcpYGeneral secretion pathway protein L; Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins. (382 aa)
rcsFConserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (231 aa)
tse3Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via muramidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi3 that specifically interacts with and inactivates cognate toxin. (408 aa)
ladSLost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (795 aa)
lspAProlipoprotein signal peptidase; This protein specifically catalyzes the removal of signal peptides from prolipoproteins. (169 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
phoRTwo-component sensor PhoR; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. (443 aa)
dsbAThiol:disulfide interchange protein DsbA; Involved in disulfide-bond formation. Acts by transferring its disulfide bond to other proteins (By similarity); Belongs to the thioredoxin family. DsbA subfamily. (211 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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