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oxyR oxyR glcC glcC algK algK exoT exoT hcp1 hcp1 glcB glcB nirS nirS algU algU mucA mucA cbpD cbpD gacS gacS oprD oprD flgE flgE fliC fliC cyoA cyoA cyoE cyoE ccoP2 ccoP2 ccoN2 ccoN2 pscP pscP exsB exsB pscL pscL liuR liuR katE katE exoY exoY hcnA hcnA hcnB hcnB hcnC hcnC pslN pslN chiC chiC gacA gacA atuR atuR atuA atuA atuH atuH fabV fabV nosZ nosZ algD algD alg8 alg8 alg44 alg44 algE algE algG algG algX algX algL algL algI algI algJ algJ algF algF algA algA exoS exoS PA3853 PA3853 rpsL rpsL algW algW katB katB retS retS arcD arcD arcB arcB arcC arcC algP algP algQ algQ algR algR algZ algZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
oxyROxyR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the LysR transcriptional regulatory family. (310 aa)
glcCTranscriptional regulator GlcC; Product name confidence: Class 2 (High similarity to functionally studied protein). (251 aa)
algKAlginate biosynthetic protein AlgK precursor; May be involved in the polymerization of mannuronate to alginate. (475 aa)
exoTProduct name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (457 aa)
hcp1Hcp1; Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients; Belongs to the hcp1 family. (162 aa)
glcBMalate synthase G; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (725 aa)
nirSNitrite reductase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (568 aa)
algUSigma factor AlgU; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates genes such as algD, involved in alginate biosynthesis. (193 aa)
mucAAnti-sigma factor MucA; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucA causes a switch from the non-mucoid to mucoid state resulting in constitutive expression of alginate biosynthetic genes. (194 aa)
cbpDChitin-binding protein CbpD precursor; Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity. (389 aa)
gacSSensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). (925 aa)
oprDBasic amino acid, basic peptide and imipenem outer membrane porin OprD precursor; Porin with a specificity for basic amino acids. Also possesses serine protease activity; Belongs to the outer membrane porin (Opr) (TC 1.B.25) family. (443 aa)
flgEFlagellar hook protein FlgE; Product name confidence: Class 2 (High similarity to functionally studied protein). (462 aa)
fliCFlagellin type B; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (488 aa)
cyoACytochrome o ubiquinol oxidase subunit II; Cytochrome bo(3) ubiquinol terminal oxidase is the component of the aerobic respiratory chain of E.coli that predominates when cells are grown at high aeration. Has proton pump activity across the membrane in addition to electron transfer, pumping 2 protons/electron (By similarity). (331 aa)
cyoECytochrome o ubiquinol oxidase protein CyoE; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (296 aa)
ccoP2Cytochrome c oxidase, cbb3-type, CcoP subunit; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. (308 aa)
ccoN2Cytochrome c oxidase, cbb3-type, CcoN subunit; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the heme-copper respiratory oxidase family. (475 aa)
pscPTranslocation protein in type III secretion; Product name confidence: Class 2 (High similarity to functionally studied protein). (369 aa)
exsBExoenzyme S synthesis protein B; Involved in the synthesis of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells. Pilot protein that is required for the proper localization of the secretin PscC in the outer membrane. Necessary for full in vivo virulence ; Belongs to the ExsB/YscW family. (137 aa)
pscLType III export protein PscL; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (214 aa)
liuRRegulator of liu genes; Class 1: Function experimentally demonstrated in P. aeruginosa. (134 aa)
katECatalase HPII; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide. Belongs to the catalase family. HPII subfamily. (709 aa)
exoYAdenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (378 aa)
hcnAHydrogen cyanide synthase HcnA; A three-component membrane-bound flavoenzyme that catalyzes the formation of hydrogen cyanide, a secondary metabolite, by transfer of electrons to a cyanide-resistant branch of the aerobic respiratory chain. (104 aa)
hcnBHydrogen cyanide synthase HcnB; A three-component membrane-bound flavoenzyme that catalyzes the formation of hydrogen cyanide, a secondary metabolite, by transfer of electrons to a cyanide-resistant branch of the aerobic respiratory chain. (464 aa)
hcnCHydrogen cyanide synthase HcnC; A three-component membrane-bound flavoenzyme that catalyzes the formation of hydrogen cyanide, a secondary metabolite, by transfer of electrons to a cyanide-resistant branch of the aerobic respiratory chain. Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. (417 aa)
pslNHypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (333 aa)
chiCChitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family. (483 aa)
gacAResponse regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. (214 aa)
atuRPutative repressor of atu genes; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (198 aa)
atuAExpressed protein with apparent function in citronellol catabolism; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (600 aa)
atuHPutative very-long chain acyl-CoA synthetase; Class 4: Homologs of previously reported genes of unknown function or no similarity to any previously reported sequences. (608 aa)
fabVHypothetical protein; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It can use both crotonyl-CoA and trans-2- decenoyl-ACP. It is able to convert trans-2-enoyl-ACP of different length (C2 to C16) to the corresponding acyl-ACP. Belongs to the TER reductase family. (398 aa)
nosZNitrous-oxide reductase precursor; Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide; Belongs to the NosZ family. (636 aa)
algDGDP-mannose 6-dehydrogenase AlgD; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. (436 aa)
alg8Alginate biosynthesis protein Alg8; Processive enzyme that polymerizes GDP-mannuronic acid. Belongs to the glycosyltransferase 2 family. (494 aa)
alg44Alginate biosynthesis protein Alg44; Required for alginate biosynthesis. Belongs to the Alg44 family. (389 aa)
algEAlginate production outer membrane protein AlgE precursor; Has non-porin-like, channel-forming properties and probably functions as an alginate permeability pore. (490 aa)
algGAlginate-c5-mannuronan-epimerase AlgG; Catalyzes the epimerization of beta-D-mannuronate to alpha-L- guluronate during the synthesis of the linear polysaccharide alginate. In addition, is part of a periplasmic protein complex that protects alginate from degradation by AlgL by channeling the newly formed alginate polymer through a scaffold that transfers the alginate polymer through the periplasmic space to the outer membrane secretin AlgE. (543 aa)
algXAlginate biosynthesis protein AlgX; Plays two roles in the biosynthesis of the exopolysaccharide alginate: protects alginate from degradation as the polymer traverses the periplasm, and also plays a role in its O-acetylation. Acetylation of alginate causes the cells in the biofilm to adhere better to lung epithelium, form microcolonies, and resist the effects of the host immune system and/or antibiotics. Displays a low acetylesterase activity in vitro using a pseudosubstrate, 3-carboxyumbelliferyl acetate. Probably has acetyltransferase activity in vivo. Belongs to the AlgX family. (474 aa)
algLPoly(beta-d-mannuronate) lyase precursor AlgL; Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism. May serve to degrade mislocalized alginate that is trapped in the periplasmic space. Acts preferentially on non-acetylated alginate or its precursor mannuronan. Is able to catalyze cleavage adjacent to either mannuronate or guluronate residues in alginate. Exhaustive digestion of alginate by AlgL generates dimeric and trimeric products. In addition to its enzymatic function, AlgL appears [...] (367 aa)
algIAlginate o-acetyltransferase AlgI; Together with AlgJ and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate is important for the architecture of biofilms and increases resistance to opsonic killing in the host. (520 aa)
algJAlginate o-acetyltransferase AlgJ; Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate is important for the architecture of biofilms and increases resistance to opsonic killing in the host. (391 aa)
algFAlginate o-acetyltransferase AlgF; Together with AlgI and AlgJ, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate is important for the architecture of biofilms and increases resistance to opsonic killing in the host. (216 aa)
algAPhosphomannose isomerase / guanosine 5'-diphospho-D-mannose pyrophosphorylase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics; Belongs to the mannose-6-phosphate isomerase type 2 family. (481 aa)
exoSExoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (453 aa)
PA3853Probable transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (229 aa)
rpsL30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (123 aa)
algWAlgW protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (389 aa)
katBCatalase; Decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; Belongs to the catalase family. (513 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
arcDArginine/ornithine antiporter; Catalyzes an electroneutral exchange between arginine and ornithine to allow high-efficiency energy conversion in the arginine deiminase pathway; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family. (482 aa)
arcBOrnithine carbamoyltransferase, catabolic; Involved in the catabolism of arginine. Catalyzes the phosphorolysis of citrulline, the reverse reaction of the biosynthetic one, yielding ornithine and carbamoyl phosphate which serve to generate ATP from ADP. This catabolic OTCase does not carry out the biosynthetic reaction because of a poor affinity and a marked cooperativity for carbamoyl phosphate. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (336 aa)
arcCCarbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (310 aa)
algPAlginate regulatory protein AlgP; The promoter for a critical alginate biosynthetic gene, AlgD, encoding GDP-mannose dehydrogenase, is activated only under conditions reminiscent of the cystic fibrosis lung (i.e. under high osmolarity), and at least two regulatory genes, AlgP and AlgQ, have been implicated in this activation process. (352 aa)
algQAlginate regulatory protein AlgQ; The promoter for a critical alginate biosynthetic gene, AlgD, encoding GDP-mannose dehydrogenase, is activated only under conditions reminiscent of the cystic fibrosis lung (i.e. under high osmolarity), and at least two regulatory genes, AlgP and AlgQ, have been implicated in this activation process. (160 aa)
algRAlginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway. (248 aa)
algZAlginate biosynthesis protein AlgZ/FimS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (358 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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