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exsE exsE gacS gacS flhA flhA gltA gltA popN popN popB popB popD popD exsC exsC exsA exsA exsD exsD pscF pscF fimL fimL kynB kynB mtlY mtlY kynA kynA gacA gacA psrA psrA gltR gltR cyaB cyaB amiE amiE rpoS rpoS exoS exoS cbrA cbrA cbrB cbrB retS retS cpdA cpdA aceE aceE algR algR crc crc exoT exoT proC proC nirS nirS prtR prtR trpA trpA ptrB ptrB vfr vfr algU algU mucA mucA prpC prpC mgtE mgtE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
exsEExsE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (81 aa)
gacSSensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). (925 aa)
flhAFlagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (707 aa)
gltACitrate synthase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (428 aa)
popNType III secretion outer membrane protein PopN precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (288 aa)
popBTranslocator protein PopB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (390 aa)
popDTranslocator outer membrane protein PopD precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (295 aa)
exsCExsC, exoenzyme S synthesis protein C precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (145 aa)
exsATranscriptional regulator ExsA; Appears to be required for induction of exoenzyme S synthesis above a low basal level. (278 aa)
exsDExsD; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (276 aa)
pscFType III export protein PscF; Major component of the type III secretion needle structure. Required for cytotoxicity on macrophages. (85 aa)
fimLHypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (562 aa)
kynBKynurenine formamidase, KynB; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation; Belongs to the Cyclase 1 superfamily. KynB family. (213 aa)
mtlYXylulose kinase; Product name confidence: Class 2 (High similarity to functionally studied protein). (502 aa)
kynAL-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing) KynA; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (288 aa)
gacAResponse regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. (214 aa)
psrATranscriptional regulator PsrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (233 aa)
gltRTwo-component response regulator GltR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (242 aa)
cyaBCyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (463 aa)
amiEAliphatic amidase; Catalyzes the hydrolysis of short-chain aliphatic amides to their corresponding organic acids with release of ammonia. Enables the organism to use acetamide as both carbon and nitrogen source; Belongs to the carbon-nitrogen hydrolase superfamily. Aliphatic amidase family. (346 aa)
rpoSSigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (334 aa)
exoSExoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (453 aa)
cbrATwo-component sensor CbrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (983 aa)
cbrBTwo-component response regulator CbrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (478 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
cpdACyclic AMP (cAMP) Phosphodiesterase, CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (272 aa)
aceEPyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (882 aa)
algRAlginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway. (248 aa)
crcCatabolite repression control protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (259 aa)
exoTProduct name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (457 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa)
nirSNitrite reductase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (568 aa)
prtRTranscriptional regulator PrtR; Represses the promoter activity of the prtN gene. (256 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa)
ptrBRepressor, PtrB; Class 1: Function experimentally demonstrated in P. aeruginosa. (66 aa)
vfrTranscriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production. (214 aa)
algUSigma factor AlgU; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates genes such as algD, involved in alginate biosynthesis. (193 aa)
mucAAnti-sigma factor MucA; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucA causes a switch from the non-mucoid to mucoid state resulting in constitutive expression of alginate biosynthetic genes. (194 aa)
prpCCitrate synthase 2; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the citrate synthase family. (375 aa)
mgtEProbable Mg transporter MgtE; Acts as a magnesium transporter. (482 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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