14 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	vgrG1	VgrG1; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1. Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity. (643 aa)
	ppkA	Serine/threonine protein kinase PpkA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (1032 aa)
	hcp1	Hcp1; Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients; Belongs to the hcp1 family. (162 aa)
	retS	RetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
	ladS	Lost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (795 aa)
	tse3	Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via muramidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi3 that specifically interacts with and inactivates cognate toxin. (408 aa)
	arr	Aminoglycoside response regulator; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (525 aa)
	tse2	Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the cytoplasm of recipient cells. Acts likely as a NAD-dependent cytotoxin towards both prokaryotic and eukaryotic cells. (158 aa)
	vgrG1c	Conserved hypothetical protein; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the Tse5/RhsP1 toxin to target cells where it exerts its toxicity. Belongs to the VgrG protein family. (726 aa)
	gacA	Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. (214 aa)
	tse1	Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin. (154 aa)
	pcrD	Type III secretory apparatus protein PcrD; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (706 aa)
	gacS	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). (925 aa)
	exoT	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (457 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
arr	gacS	PA2818	PA0928	Aminoglycoside response regulator; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.573
exoT	gacA	PA0044	PA2586	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.	0.414
exoT	gacS	PA0044	PA0928	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.491
exoT	ladS	PA0044	PA3974	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Lost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.493
exoT	pcrD	PA0044	PA1703	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Type III secretory apparatus protein PcrD; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.835
exoT	retS	PA0044	PA4856	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	RetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.495
gacA	exoT	PA2586	PA0044	Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.414
gacA	gacS	PA2586	PA0928	Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.999
gacA	ladS	PA2586	PA3974	Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.	Lost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.926
gacA	retS	PA2586	PA4856	Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.	RetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.919
gacS	arr	PA0928	PA2818	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).	Aminoglycoside response regulator; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.573
gacS	exoT	PA0928	PA0044	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.491
gacS	gacA	PA0928	PA2586	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).	Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.	0.999
gacS	ladS	PA0928	PA3974	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).	Lost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.988
gacS	ppkA	PA0928	PA0074	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).	Serine/threonine protein kinase PpkA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.552
gacS	retS	PA0928	PA4856	Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).	RetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.999
hcp1	ladS	PA0085	PA3974	Hcp1; Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients; Belongs to the hcp1 family.	Lost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.564
hcp1	ppkA	PA0085	PA0074	Hcp1; Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients; Belongs to the hcp1 family.	Serine/threonine protein kinase PpkA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.944
hcp1	retS	PA0085	PA4856	Hcp1; Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients; Belongs to the hcp1 family.	RetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.612
hcp1	tse1	PA0085	PA1844	Hcp1; Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients; Belongs to the hcp1 family.	Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin.	0.912