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| | ampR | Transcriptional regulator AmpR; This protein is a positive regulator of gene expression of beta-lactamase (AmpC); Belongs to the LysR transcriptional regulatory family. (296 aa) |
| | plcB | Phospholipase C, PlcB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (328 aa) |
| | ppkA | Serine/threonine protein kinase PpkA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (1032 aa) |
| | pcaQ | Transcriptional regulator PcaQ; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the LysR transcriptional regulatory family. (275 aa) |
| | oprM | Major intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...] (485 aa) |
| | dnr | Transcriptional regulator Dnr; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (227 aa) |
| | rpoD | Sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (617 aa) |
| | ostA | Organic solvent tolerance protein OstA precursor; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (924 aa) |
| | prtN | Transcriptional regulator PrtN; Activates pyocin genes, probably by binding to the sequences conserved in their 5' non-coding regions (P box). (104 aa) |
| | prtR | Transcriptional regulator PrtR; Represses the promoter activity of the prtN gene. (256 aa) |
| | vfr | Transcriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production. (214 aa) |
| | vreR | Sigma factor regulator, VreR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (319 aa) |
| | algU | Sigma factor AlgU; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates genes such as algD, involved in alginate biosynthesis. (193 aa) |
| | mucA | Anti-sigma factor MucA; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucA causes a switch from the non-mucoid to mucoid state resulting in constitutive expression of alginate biosynthetic genes. (194 aa) |
| | mucB | Negative regulator for alginate biosynthesis MucB; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucB causes conversion to mucoidy. (316 aa) |
| | mucC | Positive regulator for alginate biosynthesis MucC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (151 aa) |
| | mucD | Serine protease MucD precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase S1C family. (474 aa) |
| | ampDh3 | AmpDh3; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (255 aa) |
| | pbpG | D-alanyl-D-alanine-endopeptidase; Cell wall formation; Belongs to the peptidase S11 family. (310 aa) |
| | oprD | Basic amino acid, basic peptide and imipenem outer membrane porin OprD precursor; Porin with a specificity for basic amino acids. Also possesses serine protease activity; Belongs to the outer membrane porin (Opr) (TC 1.B.25) family. (443 aa) |
| | oprL | Peptidoglycan associated lipoprotein OprL precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. (168 aa) |
| | pqsE | Quinolone signal response protein; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2- aminobenzoylacetate (2-ABA), the precursor of HHQ. In vitro, can also hydrolyze other substrates such as S-ethyl-acetothioacetate and acetoacetyl-CoA, but is inactive against anthraniloyl-CoA, malonyl-CoA and octanoyl-CoA. Be [...] (301 aa) |
| | tpbB | Diguanylate cyclase TpbB; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (435 aa) |
| | oprH | PhoP/Q and low Mg2+ inducible outer membrane protein H1 precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (200 aa) |
| | aprD | Alkaline protease secretion protein AprD; Involved in the secretion of alkaline protease; Belongs to the ABC transporter superfamily. Alkaline protease exporter (TC 3.A.1.110.4) family. (593 aa) |
| | cobD | Cobalamin biosynthetic protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (312 aa) |
| | cobC | Cobalamin biosynthetic protein CobC; Decarboxylates L-threonine-O-3-phosphate to yield (R)-1- amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (331 aa) |
| | cobV | Cobalamin (5'-phosphate) synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (245 aa) |
| | lasR | Transcriptional regulator LasR; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer; Belongs to the autoinducer-regulated transcriptional regulatory protein family. (239 aa) |
| | fliA | Sigma factor FliA; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes (By similarity). Required for the flagellin gene (fliC) expression; Belongs to the sigma-70 factor family. FliA subfamily. (247 aa) |
| | cheZ | Chemotaxis protein CheZ; Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P). (262 aa) |
| | zipA | Cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. (289 aa) |
| | anr | Transcriptional regulator Anr; Transcriptional activator of anaerobic gene expression. (244 aa) |
| | sucC | succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. Can also generate UTP or CTP, although it preferentially synthesizes ATP and/or GTP. (388 aa) |
| | sucD | succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. Can also generate UTP or CTP, although it preferentially synthesizes ATP and/or GTP. (295 aa) |
| | oprF | Major porin and structural outer membrane porin OprF precursor; Has porin activity, forming small water-filled channels. Also has a structural role in determining cell shape and ability to grow in low-osmolarity medium; Belongs to the outer membrane OOP (TC 1.B.6) superfamily. (350 aa) |
| | parR | Two-component response regulator, ParR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (235 aa) |
| | clpX | ATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (426 aa) |
| | ldcA | Lysine-specific pyridoxal 5'-phosphate-dependent carboxylase, LdcA; Plays an essential role in lysine utilization by acting as a lysine decarboxylase. (751 aa) |
| | lasA | LasA protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a [...] (418 aa) |
| | opdO | Pyroglutatmate porin OpdO; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (409 aa) |
| | pslF | PslF; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (395 aa) |
| | pslG | PslG; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the glycosyl hydrolase 5 (cellulase A) family. (442 aa) |
| | pslH | PslH; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (402 aa) |
| | pslJ | PslJ; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (478 aa) |
| | mexT | Transcriptional regulator MexT; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (347 aa) |
| | oprN | Multidrug efflux outer membrane protein OprN precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (472 aa) |
| | gacA | Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. (214 aa) |
| | pqsH | Probable FAD-dependent monooxygenase; Involved in the terminal step of the biosynthesis of quinolone which in addition to serve as a potent signal for quorum sensing, chelates iron and promotes the formation of membrane vesicles (MVs). Catalyzes the hydroxylation of 2-heptyl-4-quinolone (C7-HHQ) to yield 2-heptyl-3-hydroxy-4-quinolone (PQS). Belongs to the 3-hydroxybenzoate 6-hydroxylase family. (382 aa) |
| | PA2588 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (342 aa) |
| | PA2589 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (404 aa) |
| | PA2590 | Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (884 aa) |
| | tse2 | Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the cytoplasm of recipient cells. Acts likely as a NAD-dependent cytotoxin towards both prokaryotic and eukaryotic cells. (158 aa) |
| | htpX | Heat shock protein HtpX; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase M48B family. (291 aa) |
| | ohr | Organic hydroperoxide resistance protein; Product name confidence: Class 2 (High similarity to functionally studied protein). (142 aa) |
| | oprI | Outer membrane lipoprotein OprI precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (83 aa) |
| | PA3044 | Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (741 aa) |
| | pelG | PelG; Class 1: Function experimentally demonstrated in P. aeruginosa. (456 aa) |
| | prc | Periplasmic tail-specific protease; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the peptidase S41A family. (698 aa) |
| | rhlR | Transcriptional regulator RhlR; Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone). (241 aa) |
| | tse3 | Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via muramidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi3 that specifically interacts with and inactivates cognate toxin. (408 aa) |
| | algD | GDP-mannose 6-dehydrogenase AlgD; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. (436 aa) |
| | arnT | Inner membrane L-Ara4N transferase ArnT; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (549 aa) |
| | rpoS | Sigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (334 aa) |
| | lpxD | UDP-3-O-[3-hydroxylauroyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (353 aa) |
| | opr86 | Outer membrane protein Opr86; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (797 aa) |
| | oprC | Putative copper transport outer membrane porin OprC precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (723 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. The 12-kDa membrane-associated form synthesizes GTP in preference to other nucleoside triphosphates. Important for alginate synthesis; Belongs to the NDK family. (143 aa) |
| | pbpA | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. (646 aa) |
| | oprG | Outer membrane protein OprG precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (232 aa) |
| | cupB3 | Usher CupB3; Product name confidence: Class 2 (High similarity to functionally studied protein). (844 aa) |
| | cupB2 | Chaperone CupB2; Product name confidence: Class 2 (High similarity to functionally studied protein). (248 aa) |
| | ampC | Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family. (397 aa) |
| | aph | Aminoglycoside 3'-phosphotransferase type IIb; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the aminoglycoside phosphotransferase family. (268 aa) |
| | PA4120 | Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (303 aa) |
| | bfiR | BfiR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (214 aa) |
| | bfiS | BfiS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (758 aa) |
| | mexI | Probable Resistance-Nodulation-Cell Division (RND) efflux transporter; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1029 aa) |
| | opmD | Probable outer membrane protein precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (487 aa) |
| | phzS | Flavin-containing monooxygenase; Involved in the biosynthesis of pyocyanine, a blue-pigmented phenazine derivative, which plays a role in virulence. Catalyzes the oxidative decarboxylation of 5-methylphenazine-1-carboxylate (5-methyl- PCA) to pyocyanine. Can also act on phenazine-1-carboxylate (PCA), converting it into 1-hydroxyphenazine (1-HP). However, PCA is a poor substrate. (402 aa) |
| | rplE | 50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa) |
| | rplP | 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (137 aa) |
| | PA4339 | Probable phospholipase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (359 aa) |
| | sodB | Superoxide dismutase; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (193 aa) |
| | bifA | BifA; Class 1: Function experimentally demonstrated in P. aeruginosa. (687 aa) |
| | icmP | Insulin-cleaving metalloproteinase outer membrane protein precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (446 aa) |
| | lpxC | UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (303 aa) |
| | murC | UDP-N-acetylmuramate--alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (480 aa) |
| | murG | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (357 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA); Belongs to the MurCDEF family. (448 aa) |
| | murF | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (458 aa) |
| | murE | UDP-N-acetylmuramoylalanyl-D-glutamate-2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (487 aa) |
| | ftsI | Penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin. (579 aa) |
| | rsmH | Conserved hypothetical protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (313 aa) |
| | algW | AlgW protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (389 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (421 aa) |
| | rpoN | RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (497 aa) |
| | roxS | RoxS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (422 aa) |
| | mexD | Resistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexD; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (1043 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (265 aa) |
| | mrcB | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (774 aa) |
| | PA4781 | Cyclic di-GMP phosphodiesterase; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP. Hydrolyzes c-di-GMP to GMP in a two-step reaction, via the linear intermediate 5'-phosphoguanylyl(3'->5')guanosine (pGpG). In vitro, can use pGpG as an alternative substrate and hydrolyze it into GMP. Acts in regulation of motility, synthesis of virulence determinants and biofilm architecture. May act preferentially as a pGpG binding protein. (393 aa) |
| | hfq | Hfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (82 aa) |
| | cpdA | Cyclic AMP (cAMP) Phosphodiesterase, CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (272 aa) |
| | ponA | Penicillin-binding protein 1A; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (822 aa) |
| | algP | Alginate regulatory protein AlgP; The promoter for a critical alginate biosynthetic gene, AlgD, encoding GDP-mannose dehydrogenase, is activated only under conditions reminiscent of the cystic fibrosis lung (i.e. under high osmolarity), and at least two regulatory genes, AlgP and AlgQ, have been implicated in this activation process. (352 aa) |
| | algR | Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway. (248 aa) |
| | algZ | Alginate biosynthesis protein AlgZ/FimS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (358 aa) |
| | poxB | Pyruvate dehydrogenase (cytochrome); Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the TPP enzyme family. (572 aa) |
| | algC | Phosphomannomutase AlgC; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity. Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enzyme-phospho-Ser-1 [...] (463 aa) |
| | crc | Catabolite repression control protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (259 aa) |
| | algB | Two-component response regulator AlgB; Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. Positive regulator of the alginate biosynthetic gene AlgD. (449 aa) |
| | mifS | MifS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (588 aa) |
