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pscC pscC PA1654 PA1654 hcpA hcpA vgrG2a vgrG2a rpoD rpoD hcpC hcpC vgrG2b vgrG2b vgrG1b vgrG1b vgrG1 vgrG1 ldh ldh ppkA ppkA pppA pppA vgrG1c vgrG1c tsi1 tsi1 PA1655 PA1655 PA3853 PA3853 lasB lasB retS retS vgrG5 vgrG5 PA5265 PA5265 pldA pldA vgrG4b vgrG4b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pscCType III secretion outer membrane protein PscC precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (600 aa)
PA1654Probable aminotransferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (388 aa)
hcpASecreted protein Hcp; Product name confidence: Class 2 (High similarity to functionally studied protein). (172 aa)
vgrG2aConserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. May form the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 2a/Hcp2a. In turn, may allow the delivery of the Tle4 antibacterial toxin to target cells where it exerts its toxicity (Probable). Promotes also the release of VgrG2b toxin to the host cell. (842 aa)
rpoDSigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (617 aa)
hcpCSecreted protein Hcp; Product name confidence: Class 2 (High similarity to functionally studied protein). (172 aa)
vgrG2bConserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube probably formed by haemolysin co-regulated protein 2b/Hcp2b (Probable). Allows the delivery of the Tle3 antibacterial toxin to target cells where it exerts its toxicity. Additionally, acts directly as an effector and promotes internalization by interacting with the host gamma-tubulin ring complex. Elicits toxicity also in the ba [...] (1019 aa)
vgrG1bConserved hypothetical protein; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the Tse7 toxin to target cells where it exerts toxicity through its nuclease domain. (741 aa)
vgrG1VgrG1; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1. Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity. (643 aa)
ldhLeucine dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (341 aa)
ppkASerine/threonine protein kinase PpkA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (1032 aa)
pppAPppA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (242 aa)
vgrG1cConserved hypothetical protein; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the Tse5/RhsP1 toxin to target cells where it exerts its toxicity. Belongs to the VgrG protein family. (726 aa)
tsi1Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse1. Binds to a large surface of Tse1 and thereby occludes the active site to specifically inhibits enzyme activity by forming a hydrogen bond with the catalytic diad. (172 aa)
PA1655Probable glutathione S-transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the GST superfamily. (200 aa)
PA3853Probable transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (229 aa)
lasBElastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections. (498 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
vgrG5Conserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the phospholipase effector PldB to target cells where it exerts its toxicity. Plays also a role in VgrG4b and its effector PldA secretion. (790 aa)
PA5265Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (1089 aa)
pldAProduct name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (1099 aa)
vgrG4bConserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the phospholipase effector PldA to target cells where it exerts its toxicity. (808 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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