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rpoD rpoD algU algU gacS gacS flgE flgE flgG flgG fleQ fleQ fliF fliF PA1657 PA1657 PA1664 PA1664 PA1668 PA1668 exsC exsC PA2133 PA2133 pslA pslA fpvA fpvA PA2567 PA2567 ppyR ppyR PA2867 PA2867 PA3235 PA3235 flgM flgM PA3353 PA3353 amrZ amrZ PA3401 PA3401 rhlR rhlR algD algD algL algL wspR wspR fpvB fpvB fptA fptA pchG pchG pchC pchC flp flp pctC pctC PA4843 PA4843 retS retS algB algB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpoDSigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (617 aa)
algUSigma factor AlgU; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates genes such as algD, involved in alginate biosynthesis. (193 aa)
gacSSensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). (925 aa)
flgEFlagellar hook protein FlgE; Product name confidence: Class 2 (High similarity to functionally studied protein). (462 aa)
flgGFlagellar basal-body rod protein FlgG; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the flagella basal body rod proteins family. (261 aa)
fleQTranscriptional regulator FleQ; AAA+ ATPase enhancer-binding protein that acts as a transcription regulator and plays a role in the modulation of mucin adhesion and flagellar gene expression. In addition to flagella genes, regulates also expression of biofilm-related genes. Functions as a transcriptional repressor in the absence of c-di-GMP and as an activator when c-di-GMP is present. (490 aa)
fliFFlagella M-ring outer membrane protein precursor; The M ring may be actively involved in energy transduction. (598 aa)
PA1657Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (168 aa)
PA1664Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (46 aa)
PA1668Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (289 aa)
exsCExsC, exoenzyme S synthesis protein C precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (145 aa)
PA2133Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (285 aa)
pslAPslA; Class 1: Function experimentally demonstrated in P. aeruginosa. (478 aa)
fpvAFerripyoverdine receptor; Receptor for the siderophore ferripyoverdine. (815 aa)
PA2567Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (587 aa)
ppyRPsl and pyoverdine operon regulator, PpyR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (85 aa)
PA2867Probable chemotaxis transducer; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (490 aa)
PA3235Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (103 aa)
flgMFlgM; Class 1: Function experimentally demonstrated in P. aeruginosa. (107 aa)
PA3353Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (263 aa)
amrZAlginate and motility regulator Z; Functions as both a transcriptional activator and repressor of multiple genes encoding virulence factors as well as genes involved in environmental adaptation. Plays a role in alginate production via the activation of AlgD which is the first gene in the alginate biosynthetic operon. Regulates also the transcription of genes responsible for type IV pili localization and twitching motility. Mediates transition of P.aeruginosa biofilm infections from colonizing to chronic biofilms through repression of the psl operon. Represses also its own transcription [...] (108 aa)
PA3401Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (390 aa)
rhlRTranscriptional regulator RhlR; Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone). (241 aa)
algDGDP-mannose 6-dehydrogenase AlgD; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. (436 aa)
algLPoly(beta-d-mannuronate) lyase precursor AlgL; Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism. May serve to degrade mislocalized alginate that is trapped in the periplasmic space. Acts preferentially on non-acetylated alginate or its precursor mannuronan. Is able to catalyze cleavage adjacent to either mannuronate or guluronate residues in alginate. Exhaustive digestion of alginate by AlgL generates dimeric and trimeric products. In addition to its enzymatic function, AlgL appears [...] (367 aa)
wspRProbable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (347 aa)
fpvBSecond ferric pyoverdine receptor FpvB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (802 aa)
fptAFe(III)-pyochelin outer membrane receptor precursor; High-affinity outer membrane receptor required for the transport of Fe(3+)-pyochelin. (720 aa)
pchGPyochelin biosynthetic protein PchG; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (349 aa)
pchCPyochelin biosynthetic protein PchC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (251 aa)
flpType IVb pilin, Flp; Class 1: Function experimentally demonstrated in P. aeruginosa. (72 aa)
pctCChemotactic transducer PctC; Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Responds to L-His, L-Pro and GABA. Also involved in repellent responses to trichloroethylene (TCE), chloroform and methylthiocyanate. (632 aa)
PA4843Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (542 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
algBTwo-component response regulator AlgB; Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. Positive regulator of the alginate biosynthetic gene AlgD. (449 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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