STRINGSTRING
rpoS rpoS fha1 fha1 hcp1 hcp1 eagT6 eagT6 vfr vfr algU algU mucA mucA hpd hpd rsmA rsmA ldhA ldhA gacS gacS lasR lasR exsA exsA gacA gacA pelA pelA ldh ldh opr86 opr86 exoS exoS ladS ladS rpoA rpoA retS retS algR algR algZ algZ
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpoSSigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (334 aa)
fha1Fha1; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (497 aa)
hcp1Hcp1; Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients; Belongs to the hcp1 family. (162 aa)
eagT6Hypothetical protein; Plays an essential role in toxin Tse6 delivery to target cells and specifically in the loading of Tse6 onto VgrG1a. (144 aa)
vfrTranscriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production. (214 aa)
algUSigma factor AlgU; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates genes such as algD, involved in alginate biosynthesis. (193 aa)
mucAAnti-sigma factor MucA; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucA causes a switch from the non-mucoid to mucoid state resulting in constitutive expression of alginate biosynthetic genes. (194 aa)
hpd4-hydroxyphenylpyruvate dioxygenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the 4HPPD family. (357 aa)
rsmARsmA, regulator of secondary metabolites; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). Probably [...] (61 aa)
ldhAD-lactate dehydrogenase (fermentative); Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (329 aa)
gacSSensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). (925 aa)
lasRTranscriptional regulator LasR; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer; Belongs to the autoinducer-regulated transcriptional regulatory protein family. (239 aa)
exsATranscriptional regulator ExsA; Appears to be required for induction of exoenzyme S synthesis above a low basal level. (278 aa)
gacAResponse regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. (214 aa)
pelAPelA; Class 1: Function experimentally demonstrated in P. aeruginosa. (948 aa)
ldhLeucine dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (341 aa)
opr86Outer membrane protein Opr86; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (797 aa)
exoSExoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (453 aa)
ladSLost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (795 aa)
rpoADNA-directed RNA polymerase alpha chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (333 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
algRAlginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway. (248 aa)
algZAlginate biosynthesis protein AlgZ/FimS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (358 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.