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lasB lasB fimU fimU fimT fimT pilY1 pilY1 pilY2 pilY2 pilE pilE pmrA pmrA pmrB pmrB pilQ pilQ mdoH mdoH estA estA algR algR algZ algZ algC algC algB algB mucD mucD mucC mucC mucB mucB mucA mucA algU algU rhl rhl rpoS rpoS algA algA algF algF algJ algJ algI algI algL algL algX algX algG algG algE algE algK algK alg44 alg44 alg8 alg8 algD algD rhlR rhlR rhlI rhlI amrZ amrZ lecB lecB flgM flgM pelA pelA pelB pelB pelC pelC pelD pelD pelE pelE pelF pelF pelG pelG kynA kynA lecA lecA pslA pslA qscR qscR lasA lasA lasI lasI rsaL rsaL lasR lasR aprA aprA phoQ phoQ gabT gabT phoP phoP toxA toxA fleQ fleQ flgK flgK aruD aruD pilX pilX pilW pilW pilD pilD pilV pilV
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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experimentally determined
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lasBElastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections. (498 aa)
fimUType 4 fimbrial biogenesis protein FimU; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (168 aa)
fimTType 4 fimbrial biogenesis protein FimT; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (169 aa)
pilY1Type 4 fimbrial biogenesis protein PilY1; Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili. Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity). (1161 aa)
pilY2Type 4 fimbrial biogenesis protein PilY2; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (115 aa)
pilEType 4 fimbrial biogenesis protein PilE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (141 aa)
pmrAPmrA: two-component regulator system response regulator PmrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (221 aa)
pmrBPmrB: two-component regulator system signal sensor kinase PmrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (477 aa)
pilQType 4 fimbrial biogenesis outer membrane protein PilQ precursor; Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane; Belongs to the bacterial secretin family. PilQ subfamily. (714 aa)
mdoHPeriplasmic glucans biosynthesis protein MdoH; Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs). (861 aa)
estAEsterase EstA; Esterase whose enzymatic activity is required for rhamnolipid production, all kinds of cell motility (swimming, swarming, and twitching), and biofilm formation; the exact role of EstA in these processes is unclear. In vitro, has pronounced esterase activities towards p-nitrophenyl esters of short acyl chain length (C4-C6) and Tween detergents. Also shows relatively high activity towards beta- naphthyl butyrate, whereas its activities towards triacylglycerols and acyls-CoA are negligible. (646 aa)
algRAlginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway. (248 aa)
algZAlginate biosynthesis protein AlgZ/FimS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (358 aa)
algCPhosphomannomutase AlgC; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity. Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enzyme-phospho-Ser-1 [...] (463 aa)
algBTwo-component response regulator AlgB; Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. Positive regulator of the alginate biosynthetic gene AlgD. (449 aa)
mucDSerine protease MucD precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase S1C family. (474 aa)
mucCPositive regulator for alginate biosynthesis MucC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (151 aa)
mucBNegative regulator for alginate biosynthesis MucB; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucB causes conversion to mucoidy. (316 aa)
mucAAnti-sigma factor MucA; Negative regulator of the sigma factor AlgU. Plays a role in the differentiation of P.aeruginosa into the alginate-producing form. Inactivation of mucA causes a switch from the non-mucoid to mucoid state resulting in constitutive expression of alginate biosynthetic genes. (194 aa)
algUSigma factor AlgU; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates genes such as algD, involved in alginate biosynthesis. (193 aa)
rhlATP-dependent RNA helicase RhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (397 aa)
rpoSSigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (334 aa)
algAPhosphomannose isomerase / guanosine 5'-diphospho-D-mannose pyrophosphorylase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics; Belongs to the mannose-6-phosphate isomerase type 2 family. (481 aa)
algFAlginate o-acetyltransferase AlgF; Together with AlgI and AlgJ, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate is important for the architecture of biofilms and increases resistance to opsonic killing in the host. (216 aa)
algJAlginate o-acetyltransferase AlgJ; Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate is important for the architecture of biofilms and increases resistance to opsonic killing in the host. (391 aa)
algIAlginate o-acetyltransferase AlgI; Together with AlgJ and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization-transport complex and adds acetyl groups at the O-2 and O-3 positions of mannuronate residues. Acetylation of alginate is important for the architecture of biofilms and increases resistance to opsonic killing in the host. (520 aa)
algLPoly(beta-d-mannuronate) lyase precursor AlgL; Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism. May serve to degrade mislocalized alginate that is trapped in the periplasmic space. Acts preferentially on non-acetylated alginate or its precursor mannuronan. Is able to catalyze cleavage adjacent to either mannuronate or guluronate residues in alginate. Exhaustive digestion of alginate by AlgL generates dimeric and trimeric products. In addition to its enzymatic function, AlgL appears [...] (367 aa)
algXAlginate biosynthesis protein AlgX; Plays two roles in the biosynthesis of the exopolysaccharide alginate: protects alginate from degradation as the polymer traverses the periplasm, and also plays a role in its O-acetylation. Acetylation of alginate causes the cells in the biofilm to adhere better to lung epithelium, form microcolonies, and resist the effects of the host immune system and/or antibiotics. Displays a low acetylesterase activity in vitro using a pseudosubstrate, 3-carboxyumbelliferyl acetate. Probably has acetyltransferase activity in vivo. Belongs to the AlgX family. (474 aa)
algGAlginate-c5-mannuronan-epimerase AlgG; Catalyzes the epimerization of beta-D-mannuronate to alpha-L- guluronate during the synthesis of the linear polysaccharide alginate. In addition, is part of a periplasmic protein complex that protects alginate from degradation by AlgL by channeling the newly formed alginate polymer through a scaffold that transfers the alginate polymer through the periplasmic space to the outer membrane secretin AlgE. (543 aa)
algEAlginate production outer membrane protein AlgE precursor; Has non-porin-like, channel-forming properties and probably functions as an alginate permeability pore. (490 aa)
algKAlginate biosynthetic protein AlgK precursor; May be involved in the polymerization of mannuronate to alginate. (475 aa)
alg44Alginate biosynthesis protein Alg44; Required for alginate biosynthesis. Belongs to the Alg44 family. (389 aa)
alg8Alginate biosynthesis protein Alg8; Processive enzyme that polymerizes GDP-mannuronic acid. Belongs to the glycosyltransferase 2 family. (494 aa)
algDGDP-mannose 6-dehydrogenase AlgD; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. (436 aa)
rhlRTranscriptional regulator RhlR; Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone). (241 aa)
rhlIAutoinducer synthesis protein RhlI; Required for the synthesis of BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone) autoinducer molecules which bind to RhlR and thus acts in elastase biosynthesis regulation. (201 aa)
amrZAlginate and motility regulator Z; Functions as both a transcriptional activator and repressor of multiple genes encoding virulence factors as well as genes involved in environmental adaptation. Plays a role in alginate production via the activation of AlgD which is the first gene in the alginate biosynthetic operon. Regulates also the transcription of genes responsible for type IV pili localization and twitching motility. Mediates transition of P.aeruginosa biofilm infections from colonizing to chronic biofilms through repression of the psl operon. Represses also its own transcription [...] (108 aa)
lecBFucose-binding lectin PA-IIL; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (115 aa)
flgMFlgM; Class 1: Function experimentally demonstrated in P. aeruginosa. (107 aa)
pelAPelA; Class 1: Function experimentally demonstrated in P. aeruginosa. (948 aa)
pelBPelB; Class 1: Function experimentally demonstrated in P. aeruginosa. (1193 aa)
pelCPelC; Class 1: Function experimentally demonstrated in P. aeruginosa. (172 aa)
pelDPelD; Class 1: Function experimentally demonstrated in P. aeruginosa. (455 aa)
pelEPelE; Class 1: Function experimentally demonstrated in P. aeruginosa. (329 aa)
pelFPelF; Class 1: Function experimentally demonstrated in P. aeruginosa. (507 aa)
pelGPelG; Class 1: Function experimentally demonstrated in P. aeruginosa. (456 aa)
kynAL-Tryptophan:oxygen 2,3-oxidoreductase (decyclizing) KynA; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (288 aa)
lecALecA; D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl- beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity; Belongs to the LecA/PllA lectin family. (122 aa)
pslAPslA; Class 1: Function experimentally demonstrated in P. aeruginosa. (478 aa)
qscRQuorum-sensing control repressor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (237 aa)
lasALasA protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a [...] (418 aa)
lasIAutoinducer synthesis protein LasI; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation. (201 aa)
rsaLRegulatory protein RsaL; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (80 aa)
lasRTranscriptional regulator LasR; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer; Belongs to the autoinducer-regulated transcriptional regulatory protein family. (239 aa)
aprAAlkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. (479 aa)
phoQTwo-component sensor PhoQ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (448 aa)
gabT4-aminobutyrate aminotransferase; Catalyzes the conversion of 5-aminovalerate to 5- oxopentanoate. (426 aa)
phoPTwo-component response regulator PhoP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (225 aa)
toxAExotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38. (638 aa)
fleQTranscriptional regulator FleQ; AAA+ ATPase enhancer-binding protein that acts as a transcription regulator and plays a role in the modulation of mucin adhesion and flagellar gene expression. In addition to flagella genes, regulates also expression of biofilm-related genes. Functions as a transcriptional repressor in the absence of c-di-GMP and as an activator when c-di-GMP is present. (490 aa)
flgKFlagellar hook-associated protein 1 FlgK; Product name confidence: Class 2 (High similarity to functionally studied protein). (683 aa)
aruDSuccinylglutamate 5-semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate; Belongs to the aldehyde dehydrogenase family. AstD subfamily. (488 aa)
pilXType 4 fimbrial biogenesis protein PilX; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (195 aa)
pilWType 4 fimbrial biogenesis protein PilW; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (274 aa)
pilDType 4 prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the pilin precursor during membrane translocation. Required for the assembly of type IV pili and for secretion of most proteins. (290 aa)
pilVType 4 fimbrial biogenesis protein PilV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (185 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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