20 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	pilN	Type 4 fimbrial biogenesis protein PilN; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (198 aa)
	pilM	Type 4 fimbrial biogenesis protein PilM; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (354 aa)
	PA5498	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (307 aa)
	pilF	Type 4 fimbrial biogenesis protein PilF; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (252 aa)
	pilD	Type 4 prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the pilin precursor during membrane translocation. Required for the assembly of type IV pili and for secretion of most proteins. (290 aa)
	pilV	Type 4 fimbrial biogenesis protein PilV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (185 aa)
	pilW	Type 4 fimbrial biogenesis protein PilW; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (274 aa)
	pilX	Type 4 fimbrial biogenesis protein PilX; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (195 aa)
	pilY1	Type 4 fimbrial biogenesis protein PilY1; Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili. Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity). (1161 aa)
	pilY2	Type 4 fimbrial biogenesis protein PilY2; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (115 aa)
	pilE	Type 4 fimbrial biogenesis protein PilE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (141 aa)
	pilQ	Type 4 fimbrial biogenesis outer membrane protein PilQ precursor; Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane; Belongs to the bacterial secretin family. PilQ subfamily. (714 aa)
	pilP	Type 4 fimbrial biogenesis protein PilP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (174 aa)
	pilO	Type 4 fimbrial biogenesis protein PilO; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (207 aa)
	recA	RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (346 aa)
	fimV	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (919 aa)
	pilK	Methyltransferase PilK; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (291 aa)
	pilJ	Twitching motility protein PilJ; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (682 aa)
	pilU	Twitching motility protein PilU; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (382 aa)
	pilT	Twitching motility protein PilT; May be involved in pilus retraction; Belongs to the GSP E family. (344 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PA5498	pilD	PA5498	PA4528	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the pilin precursor during membrane translocation. Required for the assembly of type IV pili and for secretion of most proteins.	0.499
PA5498	pilE	PA5498	PA4556	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 fimbrial biogenesis protein PilE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.710
PA5498	pilJ	PA5498	PA0411	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Twitching motility protein PilJ; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	0.495
PA5498	pilT	PA5498	PA0395	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Twitching motility protein PilT; May be involved in pilus retraction; Belongs to the GSP E family.	0.703
PA5498	pilU	PA5498	PA0396	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Twitching motility protein PilU; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.425
PA5498	pilV	PA5498	PA4551	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 fimbrial biogenesis protein PilV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.707
PA5498	pilW	PA5498	PA4552	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 fimbrial biogenesis protein PilW; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.696
PA5498	pilX	PA5498	PA4553	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 fimbrial biogenesis protein PilX; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.706
PA5498	pilY1	PA5498	PA4554	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 fimbrial biogenesis protein PilY1; Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili. Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity).	0.882
fimV	pilE	PA3115	PA4556	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Type 4 fimbrial biogenesis protein PilE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.588
fimV	pilF	PA3115	PA3805	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Type 4 fimbrial biogenesis protein PilF; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.828
fimV	pilJ	PA3115	PA0411	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Twitching motility protein PilJ; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	0.917
fimV	pilK	PA3115	PA0412	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Methyltransferase PilK; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.462
fimV	pilM	PA3115	PA5044	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Type 4 fimbrial biogenesis protein PilM; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.936
fimV	pilN	PA3115	PA5043	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Type 4 fimbrial biogenesis protein PilN; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.953
fimV	pilO	PA3115	PA5042	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Type 4 fimbrial biogenesis protein PilO; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.942
fimV	pilP	PA3115	PA5041	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Type 4 fimbrial biogenesis protein PilP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.896
fimV	pilQ	PA3115	PA5040	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Type 4 fimbrial biogenesis outer membrane protein PilQ precursor; Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane; Belongs to the bacterial secretin family. PilQ subfamily.	0.948
fimV	pilT	PA3115	PA0395	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Twitching motility protein PilT; May be involved in pilus retraction; Belongs to the GSP E family.	0.614
fimV	pilU	PA3115	PA0396	Motility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Twitching motility protein PilU; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.709