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rplU rplU PA0657 PA0657 phhR phhR dctA dctA PA2181 PA2181 hcnA hcnA gcvT2 gcvT2 sdaA sdaA gcvP2 gcvP2 gcvH2 gcvH2 PA2449 PA2449 mexE mexE mexF mexF oprN oprN lecA lecA rhlI rhlI PA3628 PA3628 adhC adhC narH narH narG narG narK2 narK2 narK1 narK1 rpoN rpoN glyA3 glyA3 dctD dctD gcvP1 gcvP1 gcvH1 gcvH1 sdaB sdaB gbdR gbdR glyA1 glyA1 PA5530 PA5530
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (103 aa)
PA0657Probable ATPase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (493 aa)
phhRTranscriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (519 aa)
dctAC4-dicarboxylate transport protein; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane. (436 aa)
PA2181Hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (377 aa)
hcnAHydrogen cyanide synthase HcnA; A three-component membrane-bound flavoenzyme that catalyzes the formation of hydrogen cyanide, a secondary metabolite, by transfer of electrons to a cyanide-resistant branch of the aerobic respiratory chain. (104 aa)
gcvT2Glycine cleavage system protein T2; Product name confidence: Class 2 (High similarity to functionally studied protein). (373 aa)
sdaAL-serine dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
gcvP2Glycine cleavage system protein P2; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. (959 aa)
gcvH2Glycine cleavage system protein H2; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (127 aa)
PA2449Probable transcriptional regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (511 aa)
mexEResistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexE precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (414 aa)
mexFResistance-Nodulation-Cell Division (RND) multidrug efflux transporter MexF; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (1062 aa)
oprNMultidrug efflux outer membrane protein OprN precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (472 aa)
lecALecA; D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl- beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity; Belongs to the LecA/PllA lectin family. (122 aa)
rhlIAutoinducer synthesis protein RhlI; Required for the synthesis of BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone) autoinducer molecules which bind to RhlR and thus acts in elastase biosynthesis regulation. (201 aa)
PA3628Probable esterase; Serine hydrolase involved in the detoxification of formaldehyde. (283 aa)
adhCAlcohol dehydrogenase class III; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (370 aa)
narHRespiratory nitrate reductase beta chain; Product name confidence: Class 2 (High similarity to functionally studied protein). (513 aa)
narGRespiratory nitrate reductase alpha chain; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1261 aa)
narK2Nitrite extrusion protein 2; Product name confidence: Class 2 (High similarity to functionally studied protein). (468 aa)
narK1Nitrite extrusion protein 1; Product name confidence: Class 2 (High similarity to functionally studied protein). (431 aa)
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (497 aa)
glyA3Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
dctDProbable two-component response regulator; Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. (462 aa)
gcvP1Glycine cleavage system protein P1; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (By similarity); Belongs to the GcvP family. (958 aa)
gcvH1Glycine cleavage system protein H1; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (129 aa)
sdaBL-serine dehydratase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the iron-sulfur dependent L-serine dehydratase family. (458 aa)
gbdRGbdR; Class 1: Function experimentally demonstrated in P. aeruginosa. (367 aa)
glyA1Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (417 aa)
PA5530Probable MFS dicarboxylate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (435 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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