STRINGSTRING
tse7 tse7 tse1 tse1 tsi1 tsi1 tse5 tse5 tse2 tse2 tsi2 tsi2 tse4 tse4 tse3 tse3 tsi3 tsi3 pldA pldA tse6 tse6 eagT6 eagT6 vgrG2b vgrG2b
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
tse7Hypothetical protein; Type VI secretion exported toxin that via to its DNase activity induces growth arrest and ultimately DNA degradation within target cell. The activity is initially neutralized by a cognate immunity protein Tsi7. (386 aa)
tse1Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin. (154 aa)
tsi1Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse1. Binds to a large surface of Tse1 and thereby occludes the active site to specifically inhibits enzyme activity by forming a hydrogen bond with the catalytic diad. (172 aa)
tse5Conserved hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system that acts on bacterial target cells. The producing bacterium is protected by a cognate immunity protein. (1317 aa)
tse2Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the cytoplasm of recipient cells. Acts likely as a NAD-dependent cytotoxin towards both prokaryotic and eukaryotic cells. (158 aa)
tsi2Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse2. Binds to a large surface of Tse2 and thereby occludes the active site to specifically inhibits Tse2. (77 aa)
tse4Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. (195 aa)
tse3Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via muramidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi3 that specifically interacts with and inactivates cognate toxin. (408 aa)
tsi3Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse3. Occupies Tse3 substrate binding site and prevents the substrate from entering. (145 aa)
pldAProduct name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (1099 aa)
tse6Hypothetical protein; Type VI secretion exported toxin that acts as a glycohydrolase on bacterial target cells and degrades the essential dinucleotides NAD(+) and NADP(+), thereby inducing bacteriostasis. The activity resides in the C-terminal region that is initially neutralized by the cognate immunity protein Tsi6. (430 aa)
eagT6Hypothetical protein; Plays an essential role in toxin Tse6 delivery to target cells and specifically in the loading of Tse6 onto VgrG1a. (144 aa)
vgrG2bConserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube probably formed by haemolysin co-regulated protein 2b/Hcp2b (Probable). Allows the delivery of the Tle3 antibacterial toxin to target cells where it exerts its toxicity. Additionally, acts directly as an effector and promotes internalization by interacting with the host gamma-tubulin ring complex. Elicits toxicity also in the ba [...] (1019 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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