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gacS gacS pilT pilT pilG pilG pilH pilH pilJ pilJ chpA chpA chpB chpB chpC chpC oprM oprM vfr vfr PA0657 PA0657 fleQ fleQ phoQ phoQ fliA fliA anr anr PA1611 PA1611 mucR mucR parS parS fimL fimL ercS ercS ercS-2 ercS-2 gacA gacA PA2990 PA2990 fimV fimV oprB oprB cyaB cyaB flgM flgM alg44 alg44 wspR wspR wspF wspF wspE wspE wspD wspD wspC wspC wspB wspB wspA wspA rhl rhl narL narL rocS1 rocS1 rocR rocR rocA1 rocA1 ladS ladS ampR ampR bfiR bfiR bfiS bfiS cafA cafA pilB pilB fimU fimU pilY1 pilY1 pmrB pmrB retS retS algR algR algZ algZ xpt xpt
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
gacSSensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). (925 aa)
pilTTwitching motility protein PilT; May be involved in pilus retraction; Belongs to the GSP E family. (344 aa)
pilGTwitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions. (135 aa)
pilHTwitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (121 aa)
pilJTwitching motility protein PilJ; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (682 aa)
chpAComponent of chemotactic signal transduction system; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (2472 aa)
chpBProbable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (343 aa)
chpCProbable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (168 aa)
oprMMajor intrinsic multiple antibiotic resistance efflux outer membrane protein OprM precursor; The outer membrane component of the MexAB-OprM efflux system that confers multidrug resistance. Also functions as the major efflux pump for n-hexane and p-xylene efflux. Over-expression of the pump increases antibiotic and solvent efflux capacities. Can replace the OprJ outer membrane component of the MexCD-OprJ pump; the antibiotics exported are those exported by the intact MexCD pump, showing that efflux substrate specificity is not conferred by this component. Serves as the outer membrane co [...] (485 aa)
vfrTranscriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production. (214 aa)
PA0657Probable ATPase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (493 aa)
fleQTranscriptional regulator FleQ; AAA+ ATPase enhancer-binding protein that acts as a transcription regulator and plays a role in the modulation of mucin adhesion and flagellar gene expression. In addition to flagella genes, regulates also expression of biofilm-related genes. Functions as a transcriptional repressor in the absence of c-di-GMP and as an activator when c-di-GMP is present. (490 aa)
phoQTwo-component sensor PhoQ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (448 aa)
fliASigma factor FliA; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes (By similarity). Required for the flagellin gene (fliC) expression; Belongs to the sigma-70 factor family. FliA subfamily. (247 aa)
anrTranscriptional regulator Anr; Transcriptional activator of anaerobic gene expression. (244 aa)
PA1611Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (651 aa)
mucRMucR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (685 aa)
parSTwo-component sensor, ParS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (428 aa)
fimLHypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (562 aa)
ercSErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (881 aa)
ercS-2ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (564 aa)
gacAResponse regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. (214 aa)
PA2990Probable phosphodiesterase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (240 aa)
fimVMotility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (919 aa)
oprBGlucose/carbohydrate outer membrane porin OprB precursor; Substrate-selective channel for a variety of different sugars. Could potentially facilitate the diffusion of diverse compounds, dependent on the presence of a hydroxyl group, but is presumably restricted to carbohydrates. Involved in the transport of glucose, mannitol, fructose and glycerol (sugars able to support the growth of P.aeruginosa). Facilitates glucose diffusion across the outer membrane. (454 aa)
cyaBCyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (463 aa)
flgMFlgM; Class 1: Function experimentally demonstrated in P. aeruginosa. (107 aa)
alg44Alginate biosynthesis protein Alg44; Required for alginate biosynthesis. Belongs to the Alg44 family. (389 aa)
wspRProbable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (347 aa)
wspFProbable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (335 aa)
wspEProbable chemotaxis sensor/effector fusion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (769 aa)
wspDHypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (229 aa)
wspCProbable protein methyltransferase; Involved in biofilm formation. (422 aa)
wspBHypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (171 aa)
wspAProbable chemotaxis transducer; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (542 aa)
rhlATP-dependent RNA helicase RhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (397 aa)
narLTwo-component response regulator NarL; Product name confidence: Class 2 (High similarity to functionally studied protein). (219 aa)
rocS1Probable two-component sensor; Class 1: Function experimentally demonstrated in P. aeruginosa. (1212 aa)
rocRRocR; Class 1: Function experimentally demonstrated in P. aeruginosa. (392 aa)
rocA1Two-component response regulator RocA1; Class 1: Function experimentally demonstrated in P. aeruginosa. (209 aa)
ladSLost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (795 aa)
ampRTranscriptional regulator AmpR; This protein is a positive regulator of gene expression of beta-lactamase (AmpC); Belongs to the LysR transcriptional regulatory family. (296 aa)
bfiRBfiR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (214 aa)
bfiSBfiS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (758 aa)
cafACytoplasmic axial filament protein; Product name confidence: Class 2 (High similarity to functionally studied protein). (485 aa)
pilBType 4 fimbrial biogenesis protein PilB; Involved in the translocation of the type IV pilin (PilA); Belongs to the GSP E family. (566 aa)
fimUType 4 fimbrial biogenesis protein FimU; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (168 aa)
pilY1Type 4 fimbrial biogenesis protein PilY1; Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili. Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity). (1161 aa)
pmrBPmrB: two-component regulator system signal sensor kinase PmrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (477 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
algRAlginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway. (248 aa)
algZAlginate biosynthesis protein AlgZ/FimS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (358 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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