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phzM phzM proC proC rpoD rpoD mliC mliC polB polB phzA2 phzA2 mexE mexE cifR cifR cif cif fabV fabV arnB arnB arnT arnT pilF pilF ivy ivy pmrB pmrB pmrA pmrA PA4775 PA4775 pilY1 pilY1 phzG1 phzG1 phzB1 phzB1 waaG waaG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
phzMProbable phenazine-specific methyltransferase; Involved in the biosynthesis of pyocyanine, a blue-pigmented phenazine derivative, which plays a role in virulence. Converts phenazine-1-carboxylate (PCA) to 5-methylphenazine-1-carboxylate (5- methyl-PCA); Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. (334 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (273 aa)
rpoDSigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (617 aa)
mliCMembrane-bound lysozyme inhibitor of c-type lysozyme MliC; Specifically inhibits C-type lysozymes. (127 aa)
polBDNA polymerase II; Product name confidence: Class 2 (High similarity to functionally studied protein). (787 aa)
phzA2Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. PhzA2 (operon phzA2B2C2E2F2G2) has a role in the biosynthesis of the phenazine during both planktonic growth and biofilm development, and in host infection during biofilm development. (162 aa)
mexEResistance-Nodulation-Cell Division (RND) multidrug efflux membrane fusion protein MexE precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (414 aa)
cifRCifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (196 aa)
cifCFTR inhibitory factor, Cif; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (319 aa)
fabVHypothetical protein; Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon- carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). It can use both crotonyl-CoA and trans-2- decenoyl-ACP. It is able to convert trans-2-enoyl-ACP of different length (C2 to C16) to the corresponding acyl-ACP. Belongs to the TER reductase family. (398 aa)
arnBArnB; Catalyzes the conversion of UDP-4-keto-arabinose (UDP-Ara4O) to UDP-4-amino-4-deoxy-L-arabinose (UDP-L-Ara4N). The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides; Belongs to the DegT/DnrJ/EryC1 family. ArnB subfamily. (382 aa)
arnTInner membrane L-Ara4N transferase ArnT; Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides. Belongs to the glycosyltransferase 83 family. (549 aa)
pilFType 4 fimbrial biogenesis protein PilF; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (252 aa)
ivyHypothetical protein; Strong inhibitor of lysozyme C. (153 aa)
pmrBPmrB: two-component regulator system signal sensor kinase PmrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (477 aa)
pmrAPmrA: two-component regulator system response regulator PmrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (221 aa)
PA4775Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (286 aa)
pilY1Type 4 fimbrial biogenesis protein PilY1; Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili. Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity). (1161 aa)
phzG1Probable pyridoxamine 5'-phosphate oxidase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (214 aa)
phzB1Probable phenazine biosynthesis protein; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzB1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth; Belongs to the PhzA/PhzB family. (162 aa)
waaGUDP-glucose:(heptosyl) LPS alpha 1,3-glucosyltransferase WaaG; Product name confidence: Class 2 (High similarity to functionally studied protein). (373 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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