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wzx wzx lpxA lpxA lpxB lpxB kdsA kdsA lpxL lpxL gyrA gyrA wzz wzz wbpA wbpA lpxK lpxK kdsB kdsB pilZ pilZ cheY cheY exbD1 exbD1 lpxD lpxD pilF pilF tadD tadD tadZ tadZ flp flp lpxC lpxC gmhA gmhA kdsD kdsD pilD pilD hmuV hmuV waaA waaA msbA msbA waaP waaP waaG waaG waaC waaC waaF waaF pilP pilP ntrC ntrC tonB1 tonB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
wzxO-antigen translocase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (411 aa)
lpxAUDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (258 aa)
lpxBLipid A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (378 aa)
kdsA2-dehydro-3-deoxyphosphooctonate aldolase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the KdsA family. (281 aa)
lpxLProbable lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (312 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (923 aa)
wzzO-antigen chain length regulator; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (348 aa)
wbpAUDP-N-acetyl-d-glucosamine 6-Dehydrogenase; Plays a role in the biosynthesis of B-band O antigen for serotype O5. Catalyzes the C-6 dehydrogenation of UDP-D-GlcNAc to UDP- N-acetylglucosaminuronic acid (UDP-D-GlcNAcA). (436 aa)
lpxKTetraacyldisaccharide 4*-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (332 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (254 aa)
pilZType 4 fimbrial biogenesis protein PilZ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (118 aa)
cheYTwo-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation. (124 aa)
exbD1Transport protein ExbD; Involved in the TonB-dependent energy-dependent transport of various receptor-bound substrates. (133 aa)
lpxDUDP-3-O-[3-hydroxylauroyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (353 aa)
pilFType 4 fimbrial biogenesis protein PilF; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (252 aa)
tadDTadD; Class 2: Function of highly similar gene experimentally demonstrated in another organism (and gene context consistent in terms of pathways its involved in (if known). (245 aa)
tadZTadZ; Class 2: Function of highly similar gene experimentally demonstrated in another organism (and gene context consistent in terms of pathways its involved in (if known). (394 aa)
flpType IVb pilin, Flp; Class 1: Function experimentally demonstrated in P. aeruginosa. (72 aa)
lpxCUDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (303 aa)
gmhASedoheptulose 7-phosphate isomerase GmhA; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate; Belongs to the SIS family. GmhA subfamily. (197 aa)
kdsDArabinose-5-phosphate isomerase KdsD; Involved in the biosynthesis of 3-deoxy-D-manno-octulosonate (KDO), a unique 8-carbon sugar component of lipopolysaccharides (LPSs). Catalyzes the reversible aldol-ketol isomerization between D-ribulose 5-phosphate (Ru5P) and D-arabinose 5-phosphate (A5P). (326 aa)
pilDType 4 prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the pilin precursor during membrane translocation. Required for the assembly of type IV pili and for secretion of most proteins. (290 aa)
hmuVProbable ATP-binding component of ABC transporter; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. (255 aa)
waaA3-deoxy-D-manno-octulosonic-acid (KDO) transferase; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (425 aa)
msbATransport protein MsbA; Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation. (603 aa)
waaPLipopolysaccharide kinase WaaP; Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core. The phosphorylation of the lipopolysaccharide core seems to occur prior to translocation to the periplasm and attachment of O-antigen. Also has protein-tyrosine kinase activity: autophosphorylates on all Tyr residues; in vitro can phosphorylate poly(Glu,Tyr). (268 aa)
waaGUDP-glucose:(heptosyl) LPS alpha 1,3-glucosyltransferase WaaG; Product name confidence: Class 2 (High similarity to functionally studied protein). (373 aa)
waaCProduct name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (355 aa)
waaFHeptosyltransferase II; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (345 aa)
pilPType 4 fimbrial biogenesis protein PilP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (174 aa)
ntrCTwo-component response regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (476 aa)
tonB1TonB1; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins (By similarity). (342 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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