22 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PA3488	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (232 aa)
	hcp1	Hcp1; Required for assembly of the protein secretion apparatus HSI- I. Actively secreted during chronic infection of cystic fibrosis patients; Belongs to the hcp1 family. (162 aa)
	vgrG1	VgrG1; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 1/Hcp1. Allows the delivery of the Tse6 toxin to target cells where it exerts its toxicity. (643 aa)
	tse6	Hypothetical protein; Type VI secretion exported toxin that acts as a glycohydrolase on bacterial target cells and degrades the essential dinucleotides NAD(+) and NADP(+), thereby inducing bacteriostasis. The activity resides in the C-terminal region that is initially neutralized by the cognate immunity protein Tsi6. (430 aa)
	vgrG1b	Conserved hypothetical protein; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the Tse7 toxin to target cells where it exerts toxicity through its nuclease domain. (741 aa)
	tse7	Hypothetical protein; Type VI secretion exported toxin that via to its DNase activity induces growth arrest and ultimately DNA degradation within target cell. The activity is initially neutralized by a cognate immunity protein Tsi7. (386 aa)
	vgrG2b	Conserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube probably formed by haemolysin co-regulated protein 2b/Hcp2b (Probable). Allows the delivery of the Tle3 antibacterial toxin to target cells where it exerts its toxicity. Additionally, acts directly as an effector and promotes internalization by interacting with the host gamma-tubulin ring complex. Elicits toxicity also in the ba [...] (1019 aa)
	hcpC	Secreted protein Hcp; Product name confidence: Class 2 (High similarity to functionally studied protein). (172 aa)
	PA0822	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (148 aa)
	vgrG2a	Conserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. May form the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 2a/Hcp2a. In turn, may allow the delivery of the Tle4 antibacterial toxin to target cells where it exerts its toxicity (Probable). Promotes also the release of VgrG2b toxin to the host cell. (842 aa)
	tse5	Conserved hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system that acts on bacterial target cells. The producing bacterium is protected by a cognate immunity protein. (1317 aa)
	vgrG1c	Conserved hypothetical protein; Part of the H1 type VI secretion system (H1-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the Tse5/RhsP1 toxin to target cells where it exerts its toxicity. Belongs to the VgrG protein family. (726 aa)
	tse2	Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the cytoplasm of recipient cells. Acts likely as a NAD-dependent cytotoxin towards both prokaryotic and eukaryotic cells. (158 aa)
	vgrG4b	Conserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the phospholipase effector PldA to target cells where it exerts its toxicity. (808 aa)
	pldA	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (1099 aa)
	rnfA	Conserved hypothetical protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. (194 aa)
	PA3529	Probable peroxidase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (200 aa)
	lasB	Elastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections. (498 aa)
	rpoB	DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1357 aa)
	PA5089	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (745 aa)
	vgrG5	Conserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the phospholipase effector PldB to target cells where it exerts its toxicity. Plays also a role in VgrG4b and its effector PldA secretion. (790 aa)
	PA5265	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (1089 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PA0822	PA3488	PA0822	PA3488	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.420
PA0822	PA5089	PA0822	PA5089	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.690
PA0822	PA5265	PA0822	PA5265	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.890
PA0822	pldA	PA0822	PA3487	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.512
PA0822	tse5	PA0822	PA2684	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Conserved hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system that acts on bacterial target cells. The producing bacterium is protected by a cognate immunity protein.	0.779
PA0822	tse6	PA0822	PA0093	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Type VI secretion exported toxin that acts as a glycohydrolase on bacterial target cells and degrades the essential dinucleotides NAD(+) and NADP(+), thereby inducing bacteriostasis. The activity resides in the C-terminal region that is initially neutralized by the cognate immunity protein Tsi6.	0.605
PA0822	tse7	PA0822	PA0099	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Type VI secretion exported toxin that via to its DNase activity induces growth arrest and ultimately DNA degradation within target cell. The activity is initially neutralized by a cognate immunity protein Tsi7.	0.716
PA3488	PA0822	PA3488	PA0822	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.420
PA3488	PA5089	PA3488	PA5089	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.881
PA3488	pldA	PA3488	PA3487	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.995
PA3488	rnfA	PA3488	PA3489	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Conserved hypothetical protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.	0.765
PA3488	vgrG2b	PA3488	PA0262	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Conserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube probably formed by haemolysin co-regulated protein 2b/Hcp2b (Probable). Allows the delivery of the Tle3 antibacterial toxin to target cells where it exerts its toxicity. Additionally, acts directly as an effector and promotes internalization by interacting with the host gamma-tubulin ring complex. Elicits toxicity also in the ba [...]	0.433
PA3488	vgrG4b	PA3488	PA3486	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Conserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the phospholipase effector PldA to target cells where it exerts its toxicity.	0.936
PA3488	vgrG5	PA3488	PA5090	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Conserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the phospholipase effector PldB to target cells where it exerts its toxicity. Plays also a role in VgrG4b and its effector PldA secretion.	0.431
PA5089	PA0822	PA5089	PA0822	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.690
PA5089	PA3488	PA5089	PA3488	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.881
PA5089	PA5265	PA5089	PA5265	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.522
PA5089	pldA	PA5089	PA3487	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.780
PA5089	rnfA	PA5089	PA3489	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Conserved hypothetical protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.	0.767
PA5089	vgrG4b	PA5089	PA3486	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Conserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Allows the delivery of the phospholipase effector PldA to target cells where it exerts its toxicity.	0.601