24 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fimL	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (562 aa)
	dnaA	Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). (514 aa)
	PA0101	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (415 aa)
	pilG	Twitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions. (135 aa)
	pilK	Methyltransferase PilK; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (291 aa)
	chpA	Component of chemotactic signal transduction system; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (2472 aa)
	chpC	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (168 aa)
	cat	Chloramphenicol acetyltransferase; This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm. (212 aa)
	fosA	Probable fosfomycin resistance protein; Metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin. (135 aa)
	stk1	Serine-threonine kinase Stk1; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (329 aa)
	PA2375	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (131 aa)
	pilF	Type 4 fimbrial biogenesis protein PilF; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (252 aa)
	ampC	Beta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family. (397 aa)
	pilD	Type 4 prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the pilin precursor during membrane translocation. Required for the assembly of type IV pili and for secretion of most proteins. (290 aa)
	fimT	Type 4 fimbrial biogenesis protein FimT; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (169 aa)
	fimU	Type 4 fimbrial biogenesis protein FimU; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (168 aa)
	pilV	Type 4 fimbrial biogenesis protein PilV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (185 aa)
	pilX	Type 4 fimbrial biogenesis protein PilX; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (195 aa)
	pilY1	Type 4 fimbrial biogenesis protein PilY1; Involved in pilus assembly, twitching motility and adhesion to host cells. Primes type IV pili (T4P) assembly and is required for inclusion of minor pilins PilV, PilW and PilX to the surface pili. Stabilizes assembled pilus fibers likely by antagonizing retraction mediated by PilT. Calcium-binding and calcium release by PilY1 seem to be essential for twitching motility and for regulation of pilus retraction dynamics of PilT (By similarity). (1161 aa)
	pilY2	Type 4 fimbrial biogenesis protein PilY2; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (115 aa)
	pilE	Type 4 fimbrial biogenesis protein PilE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (141 aa)
	pilQ	Type 4 fimbrial biogenesis outer membrane protein PilQ precursor; Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane; Belongs to the bacterial secretin family. PilQ subfamily. (714 aa)
	pilM	Type 4 fimbrial biogenesis protein PilM; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (354 aa)
	algR	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway. (248 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PA0101	PA2375	PA0101	PA2375	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.774
PA0101	chpC	PA0101	PA0415	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.472
PA0101	fimL	PA0101	PA1822	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.587
PA0101	stk1	PA0101	PA1671	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Serine-threonine kinase Stk1; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.521
PA2375	PA0101	PA2375	PA0101	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.774
PA2375	chpC	PA2375	PA0415	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.416
PA2375	fimL	PA2375	PA1822	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.493
PA2375	pilY2	PA2375	PA4555	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Type 4 fimbrial biogenesis protein PilY2; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.412
PA2375	stk1	PA2375	PA1671	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Serine-threonine kinase Stk1; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.590
algR	chpA	PA5261	PA0413	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.	Component of chemotactic signal transduction system; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.400
algR	chpC	PA5261	PA0415	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.657
algR	fimL	PA5261	PA1822	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	0.712
algR	fimT	PA5261	PA4549	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.	Type 4 fimbrial biogenesis protein FimT; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.489
algR	fimU	PA5261	PA4550	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.	Type 4 fimbrial biogenesis protein FimU; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.816
algR	pilE	PA5261	PA4556	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.	Type 4 fimbrial biogenesis protein PilE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.563
algR	pilF	PA5261	PA3805	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.	Type 4 fimbrial biogenesis protein PilF; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.414
algR	pilG	PA5261	PA0408	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.	Twitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions.	0.884
algR	pilM	PA5261	PA5044	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.	Type 4 fimbrial biogenesis protein PilM; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.421
algR	pilQ	PA5261	PA5040	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.	Type 4 fimbrial biogenesis outer membrane protein PilQ precursor; Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane; Belongs to the bacterial secretin family. PilQ subfamily.	0.453
algR	pilV	PA5261	PA4551	Alginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway.	Type 4 fimbrial biogenesis protein PilV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.660