STRINGSTRING
ampC ampC retS retS ampDh2 ampDh2 PA3853 PA3853 pldA pldA tsi3 tsi3 ampDh3 ampDh3 PA0372 PA0372 PA0371 PA0371 vgrG2b vgrG2b clpV1 clpV1 rhl rhl ampD ampD tse3 tse3 amrZ amrZ pelB pelB katN katN tsi1 tsi1 tse1 tse1 vgrG2a vgrG2a PA0808 PA0808
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ampCBeta-lactamase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-C beta-lactamase family. (397 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
ampDh2AmpDh2; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (259 aa)
PA3853Probable transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (229 aa)
pldAProduct name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (1099 aa)
tsi3Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse3. Occupies Tse3 substrate binding site and prevents the substrate from entering. (145 aa)
ampDh3AmpDh3; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (255 aa)
PA0372Probable zinc protease; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (465 aa)
PA0371Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (495 aa)
vgrG2bConserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. Forms the spike at the tip of the elongating tube probably formed by haemolysin co-regulated protein 2b/Hcp2b (Probable). Allows the delivery of the Tle3 antibacterial toxin to target cells where it exerts its toxicity. Additionally, acts directly as an effector and promotes internalization by interacting with the host gamma-tubulin ring complex. Elicits toxicity also in the ba [...] (1019 aa)
clpV1ClpV1; Required for secretion of hcp1 probably by providing the energy source for its translocation; Belongs to the ClpA/ClpB family. (902 aa)
rhlATP-dependent RNA helicase RhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily. (397 aa)
ampDBeta-lactamase expression regulator AmpD; Product name confidence: Class 2 (High similarity to functionally studied protein). (188 aa)
tse3Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via muramidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi3 that specifically interacts with and inactivates cognate toxin. (408 aa)
amrZAlginate and motility regulator Z; Functions as both a transcriptional activator and repressor of multiple genes encoding virulence factors as well as genes involved in environmental adaptation. Plays a role in alginate production via the activation of AlgD which is the first gene in the alginate biosynthetic operon. Regulates also the transcription of genes responsible for type IV pili localization and twitching motility. Mediates transition of P.aeruginosa biofilm infections from colonizing to chronic biofilms through repression of the psl operon. Represses also its own transcription [...] (108 aa)
pelBPelB; Class 1: Function experimentally demonstrated in P. aeruginosa. (1193 aa)
katNNon-heme catalase KatN; Product name confidence: Class 2 (High similarity to functionally studied protein). (294 aa)
tsi1Hypothetical protein; Immunity protein that plays a role in preventing early activation of toxin Tse1. Binds to a large surface of Tse1 and thereby occludes the active site to specifically inhibits enzyme activity by forming a hydrogen bond with the catalytic diad. (172 aa)
tse1Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin. (154 aa)
vgrG2aConserved hypothetical protein; Part of the H2 type VI secretion system (H2-T6SS) specialized secretion system, which delivers several virulence factors in both prokaryotic and eukaryotic cells during infection. May form the spike at the tip of the elongating tube formed by haemolysin co-regulated protein 2a/Hcp2a. In turn, may allow the delivery of the Tle4 antibacterial toxin to target cells where it exerts its toxicity (Probable). Promotes also the release of VgrG2b toxin to the host cell. (842 aa)
PA0808Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (157 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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