Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).

Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.

Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).

Elastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections.

Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).

LecA; D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl- beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity; Belongs to the LecA/PllA lectin family.

Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).

Fucose-binding lectin PA-IIL; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).

Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).

Two-component response regulator, PprB; Member of the two-component regulatory system PprA/PprB involved in biofilm formation by controlling the expression of many related genes including type IVb pili major subunit flp pilin, adhesin bapA or cupE fimbriae. Modulates also quorum-sensing signal production acting on both negative and positive modulators. Functions as a transcription regulator by direct binding to promoter regions. Negatively regulates its own transcription.

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

Response regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase.

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

Sensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein).

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

LasA protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a [...]

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

Elastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections.

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

Autoinducer synthesis protein LasI; Required for the synthesis of PAI consisting of 3-oxo-N- (tetrahydro-2-oxo-3-furanyl)-dodecanamide also known as N-(3- oxododecanoyl)homoserine lactone, an autoinducer molecule which binds to LasR and thus acts in elastase biosynthesis regulation.

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

Transcriptional regulator LasR; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer; Belongs to the autoinducer-regulated transcriptional regulatory protein family.

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

LecA; D-galactose specific lectin. Binds in decreasing order of affinity: melibiose, methyl-alpha-D-galactoside, D-galactose, methyl- beta-D-galactoside, N-acetyl-D-galactosamine. Similar to plant lectins in its selective (carbohydrate-specific) hemagglutinating activity; Belongs to the LecA/PllA lectin family.

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

Fucose-binding lectin PA-IIL; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

Transcriptional regulator MvfR; Transcription regulator that plays a critical role in virulence by positively regulating the expression of multiple quorum sensing (QS)-regulated virulence factors, genes involved in protein secretion, translation, response to oxidative stress and the phnAB operon. At the stationary phase, negatively autoregulates its function through cleavage and translocation to the extracellular space ; Belongs to the LysR transcriptional regulatory family.

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

Probable coenzyme A ligase; Catalyzes the formation of anthraniloyl-CoA, which is the priming step for entry into the Pseudomonas quinolone signal (PQS) biosynthetic pathway. Also active on a variety of aromatic substrates, including benzoate and chloro and fluoro derivatives of anthranilate.

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

Quinolone signal response protein; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. Catalyzes the hydrolysis of the intermediate 2-aminobenzoylacetyl-CoA (2-ABA-CoA) to form 2- aminobenzoylacetate (2-ABA), the precursor of HHQ. In vitro, can also hydrolyze other substrates such as S-ethyl-acetothioacetate and acetoacetyl-CoA, but is inactive against anthraniloyl-CoA, malonyl-CoA and octanoyl-CoA. Be [...]

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

ATP-dependent RNA helicase RhlB; DEAD-box RNA helicase involved in RNA degradation. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. Belongs to the DEAD box helicase family. RhlB subfamily.

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

Autoinducer synthesis protein RhlI; Required for the synthesis of BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone) autoinducer molecules which bind to RhlR and thus acts in elastase biosynthesis regulation.

Chitinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the glycosyl hydrolase 18 family.

Transcriptional regulator RhlR; Necessary for transcriptional activation of the rhlAB genes encoding the rhamnosyltransferase. It also functions as a transcriptional activator of elastase structural gene (lasB). Binds to autoinducer molecules BHL (N-butanoyl-L-homoserine lactone), and HHL (N-hexanoyl-L-homoserine lactone).

Adenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein).

CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).