27 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ansA	Product name confidence: Class 2 (High similarity to functionally studied protein). (328 aa)
	gltS	Glutamate/sodium ion symporter, GltS; Catalyzes the sodium-dependent transport of glutamate. Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family. (404 aa)
	dsbC	Thiol:disulfide interchange protein DsbC; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily. (242 aa)
	flp	Type IVb pilin, Flp; Class 1: Function experimentally demonstrated in P. aeruginosa. (72 aa)
	rpoN	RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (497 aa)
	PA5073	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences); Belongs to the UPF0158 family. (153 aa)
	PA5076	Probable binding protein component of ABC transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the bacterial solute-binding protein 3 family. (266 aa)
	dctB	Probable two-component sensor; Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. DctB functions as a membrane-associated protein kinase that phosphorylates DctD in response to environmental signals (By similarity). (612 aa)
	dctD	Probable two-component response regulator; Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. (462 aa)
	dctQ	Probable dicarboxylate transporter; Part of the tripartite ATP-independent periplasmic (TRAP) transport system DctPQM involved in C4-dicarboxylates uptake. Belongs to the TRAP transporter small permease family. (210 aa)
	gltP	Proton-glutamate symporter; Catalyzes the proton-dependent transport of glutamate and aspartate; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily. (444 aa)
	mifR	MifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (447 aa)
	mifS	MifS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (588 aa)
	PA5530	Probable MFS dicarboxylate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (435 aa)
	dnr	Transcriptional regulator Dnr; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (227 aa)
	ggt	Gamma-glutamyltranspeptidase precursor; Product name confidence: Class 2 (High similarity to functionally studied protein). (557 aa)
	ansB	Glutaminase-asparaginase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the asparaginase 1 family. (362 aa)
	PA1336	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (633 aa)
	PA1339	Amino acid ABC transporter ATP binding protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (244 aa)
	dctA	C4-dicarboxylate transport protein; Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the inner membrane. (436 aa)
	PA1340	Amino acid ABC transporter membrane protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (222 aa)
	rpoD	Sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (617 aa)
	PA1341	Amino acid ABC transporter membrane protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (248 aa)
	PA1342	Probable binding protein component of ABC transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (302 aa)
	ppsA	Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (791 aa)
	ercS	ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (881 aa)
	ercS-2	ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (564 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PA1336	PA1339	PA1336	PA1339	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Amino acid ABC transporter ATP binding protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.521
PA1336	PA1340	PA1336	PA1340	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Amino acid ABC transporter membrane protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.596
PA1336	PA1341	PA1336	PA1341	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Amino acid ABC transporter membrane protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.665
PA1336	PA1342	PA1336	PA1342	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Probable binding protein component of ABC transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.535
PA1336	PA5073	PA1336	PA5073	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences); Belongs to the UPF0158 family.	0.493
PA1336	PA5530	PA1336	PA5530	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Probable MFS dicarboxylate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.595
PA1336	ansB	PA1336	PA1337	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Glutaminase-asparaginase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the asparaginase 1 family.	0.777
PA1336	dctD	PA1336	PA5166	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Probable two-component response regulator; Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA.	0.886
PA1336	dsbC	PA1336	PA3737	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Thiol:disulfide interchange protein DsbC; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily.	0.421
PA1336	ercS	PA1336	PA1976	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.457
PA1336	ercS-2	PA1336	PA1992	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.636
PA1336	ggt	PA1336	PA1338	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Gamma-glutamyltranspeptidase precursor; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.550
PA1336	gltP	PA1336	PA5479	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Proton-glutamate symporter; Catalyzes the proton-dependent transport of glutamate and aspartate; Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. GltP subfamily.	0.436
PA1336	mifR	PA1336	PA5511	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	MifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.850
PA1336	mifS	PA1336	PA5512	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	MifS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.400
PA1339	PA1336	PA1339	PA1336	Amino acid ABC transporter ATP binding protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.521
PA1339	PA1340	PA1339	PA1340	Amino acid ABC transporter ATP binding protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	Amino acid ABC transporter membrane protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.999
PA1339	PA1341	PA1339	PA1341	Amino acid ABC transporter ATP binding protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	Amino acid ABC transporter membrane protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.999
PA1339	PA1342	PA1339	PA1342	Amino acid ABC transporter ATP binding protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	Probable binding protein component of ABC transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.995
PA1339	PA5073	PA1339	PA5073	Amino acid ABC transporter ATP binding protein; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences); Belongs to the UPF0158 family.	0.418