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prpB prpB prpC prpC mifR mifR flhA flhA flhB flhB fliQ fliQ PA1195 PA1195 fliE fliE glnK glnK fleR fleR fleQ fleQ flgG flgG amtB amtB flgB flgB dctD dctD ntrC ntrC glnA glnA hfq hfq rtcR rtcR pilR pilR rpoN rpoN rpoS rpoS fliA fliA fleN fleN flhF flhF phhR phhR PA5530 PA5530 algB algB crc crc
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
prpBCarboxyphosphonoenolpyruvate phosphonomutase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (298 aa)
prpCCitrate synthase 2; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the citrate synthase family. (375 aa)
mifRMifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (447 aa)
flhAFlagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (707 aa)
flhBFlagellar biosynthetic protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (378 aa)
fliQFlagellar biosynthetic protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa)
PA1195Hypothetical protein; Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)- monomethyl-L-arginine (MMA). (254 aa)
fliEFlagellar hook-basal body complex protein FliE; Product name confidence: Class 2 (High similarity to functionally studied protein). (109 aa)
glnKNitrogen regulatory protein P-II 2; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the P(II) protein family. (112 aa)
fleRTwo-component response regulator; Plays a role in the regulation of both flagellar synthesis and adhesion to mucin. (473 aa)
fleQTranscriptional regulator FleQ; AAA+ ATPase enhancer-binding protein that acts as a transcription regulator and plays a role in the modulation of mucin adhesion and flagellar gene expression. In addition to flagella genes, regulates also expression of biofilm-related genes. Functions as a transcriptional repressor in the absence of c-di-GMP and as an activator when c-di-GMP is present. (490 aa)
flgGFlagellar basal-body rod protein FlgG; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the flagella basal body rod proteins family. (261 aa)
amtBAmmonium transporter AmtB; Product name confidence: Class 2 (High similarity to functionally studied protein). (442 aa)
flgBFlagellar basal-body rod protein FlgB; Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body. (135 aa)
dctDProbable two-component response regulator; Member of the two-component regulatory system DctB/DctD, which regulates C4-dicarboxylate transport via regulation of expression of the dctPQM operon and dctA. (462 aa)
ntrCTwo-component response regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (476 aa)
glnAGlutamine synthetase; Catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia; Belongs to the glutamine synthetase family. (469 aa)
hfqHfq; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. Belongs to the Hfq family. (82 aa)
rtcRTranscriptional regulator RtcR; Product name confidence: Class 2 (High similarity to functionally studied protein). (531 aa)
pilRTwo-component response regulator PilR; Member of the two-component regulatory system PilS/PilR that regulates the expression of type 4 fimbriae. When activated by PilS it acts in conjunction with sigma-54 as a transcriptional activator. (445 aa)
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (497 aa)
rpoSSigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (334 aa)
fliASigma factor FliA; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes (By similarity). Required for the flagellin gene (fliC) expression; Belongs to the sigma-70 factor family. FliA subfamily. (247 aa)
fleNFlagellar synthesis regulator FleN; ATPase that plays an important role in maintaining flagellar number in Pseudomonas aeruginosa. Exhibits anti-activator activity against FleQ, the global transcriptional regulator of flagellar genes ; Belongs to the ParA family. (280 aa)
flhFFlagellar biosynthesis protein FlhF; Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum (By similarity); Belongs to the GTP-binding SRP family. (429 aa)
phhRTranscriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (519 aa)
PA5530Probable MFS dicarboxylate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (435 aa)
algBTwo-component response regulator AlgB; Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. Positive regulator of the alginate biosynthetic gene AlgD. (449 aa)
crcCatabolite repression control protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (259 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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