11 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	cyaB	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (463 aa)
	pilT	Twitching motility protein PilT; May be involved in pilus retraction; Belongs to the GSP E family. (344 aa)
	pilH	Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (121 aa)
	vfr	Transcriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production. (214 aa)
	fliM	Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity). (323 aa)
	cheY	Two-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation. (124 aa)
	soxR	SoxR; Activates the transcription of the soxS gene which itself controls the superoxide response regulon. SoxR contains a 2Fe-2S iron- sulfur cluster that may act as a redox sensor system that recognizes superoxide. The variable redox state of the Fe-S cluster is employed in vivo to modulate the transcriptional activity of SoxR in response to specific types of oxidative stress (By similarity). (156 aa)
	wspR	Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (347 aa)
	PA4142	Probable secretion protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (418 aa)
	mifR	MifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (447 aa)
	mifS	MifS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (588 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
cheY	cyaB	PA1456	PA3217	Two-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation.	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.632
cheY	fliM	PA1456	PA1443	Two-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation.	Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).	0.998
cheY	pilH	PA1456	PA0409	Two-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation.	Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	0.935
cheY	pilT	PA1456	PA0395	Two-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation.	Twitching motility protein PilT; May be involved in pilus retraction; Belongs to the GSP E family.	0.480
cheY	wspR	PA1456	PA3702	Two-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation.	Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.882
cyaB	cheY	PA3217	PA1456	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Two-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation.	0.632
cyaB	pilH	PA3217	PA0409	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	0.978
cyaB	pilT	PA3217	PA0395	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Twitching motility protein PilT; May be involved in pilus retraction; Belongs to the GSP E family.	0.422
cyaB	vfr	PA3217	PA0652	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Transcriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production.	0.995
cyaB	wspR	PA3217	PA3702	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.458
fliM	cheY	PA1443	PA1456	Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).	Two-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation.	0.998
fliM	mifR	PA1443	PA5511	Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).	MifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.510
mifR	fliM	PA5511	PA1443	MifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	Flagellar motor switch protein FliM; FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity).	0.510
mifR	mifS	PA5511	PA5512	MifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	MifS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.998
mifS	mifR	PA5512	PA5511	MifS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	MifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.998
pilH	cheY	PA0409	PA1456	Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	Two-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation.	0.935
pilH	cyaB	PA0409	PA3217	Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	CyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.978
pilH	pilT	PA0409	PA0395	Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	Twitching motility protein PilT; May be involved in pilus retraction; Belongs to the GSP E family.	0.951
pilH	vfr	PA0409	PA0652	Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	Transcriptional regulator Vfr; Can bind cyclic AMP. Is a global regulator of virulence factor expression and is required for exotoxin A and protease production.	0.703
pilH	wspR	PA0409	PA3702	Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.507