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nosZ nosZ gyrB gyrB phzH phzH pilG pilG pilH pilH pilJ pilJ pilK pilK nirS nirS norB norB rpoD rpoD PA0918 PA0918 sdhC sdhC sdhD sdhD sdhA sdhA sdhB sdhB phzC2 phzC2 phzD2 phzD2 phzE2 phzE2 phzF2 phzF2 ercS ercS ercS-2 ercS-2 PA2345 PA2345 PA2566 PA2566 pilZ pilZ purL purL narG narG phzC1 phzC1 phzD1 phzD1 phzE1 phzE1 phzF1 phzF1 phzG1 phzG1 rpoB rpoB PA4429 PA4429 PA4430 PA4430 PA4431 PA4431 pilB pilB pilV pilV pilW pilW pilE pilE ribF ribF PA4571 PA4571 pilQ pilQ pilP pilP pilO pilO pilN pilN pilM pilM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
nosZNitrous-oxide reductase precursor; Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide; Belongs to the NosZ family. (636 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (806 aa)
phzHPotential phenazine-modifying enzyme; Product name confidence: Class 2 (High similarity to functionally studied protein). (610 aa)
pilGTwitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions. (135 aa)
pilHTwitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (121 aa)
pilJTwitching motility protein PilJ; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (682 aa)
pilKMethyltransferase PilK; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (291 aa)
nirSNitrite reductase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (568 aa)
norBNitric-oxide reductase subunit B; Component of the anaerobic respiratory chain that transforms nitrate to dinitrogen (denitrification). NorB is the catalytic subunit of the enzyme complex. Shows proton pump activity across the membrane in denitrifying bacterial cells. The mononitrogen reduction is probably coupled to electron transport phosphorylation (By similarity). (466 aa)
rpoDSigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (617 aa)
PA0918Cytochrome b561; Product name confidence: Class 2 (High similarity to functionally studied protein). (182 aa)
sdhCSuccinate dehydrogenase (C subunit); Product name confidence: Class 2 (High similarity to functionally studied protein). (128 aa)
sdhDSuccinate dehydrogenase (D subunit); Membrane-anchoring subunit of succinate dehydrogenase (SDH). (122 aa)
sdhASuccinate dehydrogenase (A subunit); Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (590 aa)
sdhBSuccinate dehydrogenase (B subunit); Product name confidence: Class 2 (High similarity to functionally studied protein). (235 aa)
phzC2Phenazine biosynthesis protein PhzC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (405 aa)
phzD2Phenazine biosynthesis protein PhzD; Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule. PhzD1 (operon phzA1B1C1E1F1G1) has a role in the biosynthesis of the phenazine during planktonic growth. Catalyzes the hydrolysis of the vinyl ether functional group of 2-amino-2-deoxyisochorismate (ADIC), yielding pyruvate and trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA). Also able to act on isochorismate, chorismate and 4-amino-4-deoxychorismate (ADC) as substrates ; Belongs to the isochorismatase family. (207 aa)
phzE2Phenazine biosynthesis protein PhzE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (627 aa)
phzF2Probable phenazine biosynthesis protein; Isomerase that catalyzes the condensation of two molecules of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) into the phenazine ring system. The final product is not yet known. (278 aa)
ercSErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (881 aa)
ercS-2ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (564 aa)
PA2345Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (411 aa)
PA2566Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (395 aa)
pilZType 4 fimbrial biogenesis protein PilZ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (118 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1298 aa)
narGRespiratory nitrate reductase alpha chain; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1261 aa)
phzC1Phenazine biosynthesis protein PhzC; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (405 aa)
phzD1Phenazine biosynthesis protein PhzD; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (207 aa)
phzE1Phenazine biosynthesis protein PhzE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (627 aa)
phzF1Probable phenazine biosynthesis protein; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (278 aa)
phzG1Probable pyridoxamine 5'-phosphate oxidase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (214 aa)
rpoBDNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1357 aa)
PA4429Probable cytochrome c1 precursor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (260 aa)
PA4430Probable cytochrome b; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (403 aa)
PA4431Probable iron-sulfur protein; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (197 aa)
pilBType 4 fimbrial biogenesis protein PilB; Involved in the translocation of the type IV pilin (PilA); Belongs to the GSP E family. (566 aa)
pilVType 4 fimbrial biogenesis protein PilV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (185 aa)
pilWType 4 fimbrial biogenesis protein PilW; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (274 aa)
pilEType 4 fimbrial biogenesis protein PilE; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (141 aa)
ribFRiboflavin kinase/FAD synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the ribF family. (312 aa)
PA4571Probable cytochrome c; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (675 aa)
pilQType 4 fimbrial biogenesis outer membrane protein PilQ precursor; Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane; Belongs to the bacterial secretin family. PilQ subfamily. (714 aa)
pilPType 4 fimbrial biogenesis protein PilP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (174 aa)
pilOType 4 fimbrial biogenesis protein PilO; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (207 aa)
pilNType 4 fimbrial biogenesis protein PilN; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (198 aa)
pilMType 4 fimbrial biogenesis protein PilM; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (354 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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