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narX narX pctC pctC pctA pctA pctB pctB ctpL ctpL retS retS ntrB ntrB ntrC ntrC PA5207 PA5207 phoB phoB phoR phoR pstS pstS PA4292 PA4292 aer2 aer2 spuD spuD spuE spuE pilG pilG pilH pilH pilJ pilJ PA0450 PA0450 phoA2 phoA2 aotJ aotJ gacS gacS braC braC PA1243 PA1243 cheY cheY cheB1 cheB1 aer aer ercS ercS ercS-2 ercS-2 ctpH ctpH PA2573 PA2573 PA2881 PA2881 PA2882 PA2882 fimV fimV cyaB cyaB wspA wspA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
narXTwo-component sensor NarX; Product name confidence: Class 2 (High similarity to functionally studied protein). (622 aa)
pctCChemotactic transducer PctC; Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Responds to L-His, L-Pro and GABA. Also involved in repellent responses to trichloroethylene (TCE), chloroform and methylthiocyanate. (632 aa)
pctAChemotactic transducer PctA; Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Major receptor that responds to all naturally occurring L- amino acids, except L-Gln and L-Asp. Also involved in repellent responses to trichloroethylene (TCE), chloroform and methylthiocyanate. (629 aa)
pctBChemotactic transducer PctB; Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Responds to L-Arg, L-Gln, L-Ala, L-Glu, L-Lys, L-Met and L-Tyr. Also involved in repellent responses to trichloroethylene (TCE), chloroform and methylthiocyanate. (629 aa)
ctpLProbable chemotaxis transducer; Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for inorganic phosphate, which is required for taxis at low concentrations of phosphate. Is also responsible for the positive chemotaxis toward 4-chloroaniline (4CA) and catechol. Does not recognize inorganic phosphate directly, but via a complex between the periplasmic protei [...] (657 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
ntrBTwo-component sensor NtrB; Product name confidence: Class 2 (High similarity to functionally studied protein). (358 aa)
ntrCTwo-component response regulator NtrC; Member of the two-component regulatory system NtrB/NtrC, which controls expression of the nitrogen-regulated (ntr) genes in response to nitrogen limitation. Phosphorylated NtrC binds directly to DNA and stimulates the formation of open promoter-sigma54-RNA polymerase complexes. (476 aa)
PA5207Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (422 aa)
phoBTwo-component response regulator PhoB; This protein is a positive regulator for the phosphate regulon. Transcription of this operon is positively regulated by PhoB and PhoR when phosphate is limited. (229 aa)
phoRTwo-component sensor PhoR; Member of the two-component regulatory system PhoR/PhoB involved in the phosphate regulon genes expression. PhoR may function as a membrane-associated protein kinase that phosphorylates PhoB in response to environmental signals. (443 aa)
pstSPhosphate ABC transporter, periplasmic phosphate-binding protein, PstS; Binds 1 inorganic phosphate per subunit with a KD of 0.34 uM. Required for phosphate transport. In strain PAO1 implicated in host cell adhesion; in some virulent strains (e.g. MDR25 which expresses very high levels of this protein) antibody fragments against this protein decrease host cell adhesion and increase transepithelial resistance of human epithelial cell monolayers. Its ability to bind phosphate may allow it to acquire phosphate from its host ; Belongs to the PstS family. (323 aa)
PA4292Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (489 aa)
aer2Aerotaxis transducer Aer2; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (679 aa)
spuDPolyamine transport protein; Putrescine-binding protein probably required for putrescine uptake into cells. Binds putrescine with high affinity (KD=3 nM), spermidine with relatively low affinity (KD=6.8 uM). Does not bind cadaverine or spermine. Putrescine binding induces large inter-domain conformational changes. (367 aa)
spuEPolyamine transport protein; Spermidine-binding protein probably required for its uptake into cells. Binds spermidine with high affinity (KD=14.3 nM). Does not bind putrescine, cadaverine or spermine. Spermidine binding induces large inter-domain conformational changes. Implicated in induction of type 3 secretion systems (T3SS), which play a role in virulence. (365 aa)
pilGTwitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions. (135 aa)
pilHTwitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (121 aa)
pilJTwitching motility protein PilJ; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (682 aa)
PA0450Probable phosphate transporter; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (540 aa)
phoA2Probable binding protein component of ABC transporter; Has both a phosphomonoesterase and phosphodiesterase activity; Belongs to the PstS family. (368 aa)
aotJArginine/ornithine binding protein AotJ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the bacterial solute-binding protein 3 family. (259 aa)
gacSSensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). (925 aa)
braCBranched-chain amino acid transport protein BraC; Component of the high-affinity leucine, isoleucine, valine transport system I (LIV-I), which is operative without Na(+) and is specific for alanine and threonine, in addition to branched-chain amino acids; Belongs to the leucine-binding protein family. (373 aa)
PA1243Probable sensor/response regulator hybrid; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (858 aa)
cheYTwo-component response regulator CheY; Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheY is likely to be involved in changing the direction of flagellar rotation. (124 aa)
cheB1Probable methyltransferase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. (368 aa)
aerAerotaxis receptor Aer; Product name confidence: Class 2 (High similarity to functionally studied protein). (521 aa)
ercSErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (881 aa)
ercS-2ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (564 aa)
ctpHProbable chemotaxis transducer; Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. Chemoreceptor for inorganic phosphate, which is required for taxis at high concentrations of phosphate. Recognizes inorganic phosphate directly. Can also bind to other components that have a pyrophosphate group, including ATP and ADP. (568 aa)
PA2573Probable chemotaxis transducer; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (535 aa)
PA2881Probable two-component response regulator; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (303 aa)
PA2882Probable two-component sensor; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (371 aa)
fimVMotility protein FimV; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (919 aa)
cyaBCyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (463 aa)
wspAProbable chemotaxis transducer; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (542 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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