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rocA1 rocA1 pilG pilG cbpD cbpD rsmA rsmA fliC fliC toxA toxA exoT exoT exoY exoY gltR gltR algD algD exoS exoS rocS1 rocS1 algB algB algC algC algZ algZ algR algR retS retS cbrA cbrA bfmS bfmS bfmR bfmR ladS ladS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rocA1Two-component response regulator RocA1; Class 1: Function experimentally demonstrated in P. aeruginosa. (209 aa)
pilGTwitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions. (135 aa)
cbpDChitin-binding protein CbpD precursor; Binds chitin but does not hydrolyze it, has no detectable protease or staphylolytic activity. (389 aa)
rsmARsmA, regulator of secondary metabolites; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s). Probably [...] (61 aa)
fliCFlagellin type B; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (488 aa)
toxAExotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38. (638 aa)
exoTProduct name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (457 aa)
exoYAdenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (378 aa)
gltRTwo-component response regulator GltR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (242 aa)
algDGDP-mannose 6-dehydrogenase AlgD; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. (436 aa)
exoSExoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (453 aa)
rocS1Probable two-component sensor; Class 1: Function experimentally demonstrated in P. aeruginosa. (1212 aa)
algBTwo-component response regulator AlgB; Member of the two-component regulatory system AlgB/KinB involved in regulation of alginate biosynthesis genes. Positive regulator of the alginate biosynthetic gene AlgD. (449 aa)
algCPhosphomannomutase AlgC; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity. Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enzyme-phospho-Ser-1 [...] (463 aa)
algZAlginate biosynthesis protein AlgZ/FimS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (358 aa)
algRAlginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway. (248 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
cbrATwo-component sensor CbrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (983 aa)
bfmSBfmS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (434 aa)
bfmRBfmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (246 aa)
ladSLost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (795 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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