19 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

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experimentally determined

Predicted Interactions

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Your Input:
	pilG	Twitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions. (135 aa)
	pilJ	Twitching motility protein PilJ; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (682 aa)
	chpB	Probable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (343 aa)
	PA5498	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (307 aa)
	pilT	Twitching motility protein PilT; May be involved in pilus retraction; Belongs to the GSP E family. (344 aa)
	pilU	Twitching motility protein PilU; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (382 aa)
	pilH	Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction). (121 aa)
	chpC	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (168 aa)
	pscP	Translocation protein in type III secretion; Product name confidence: Class 2 (High similarity to functionally studied protein). (369 aa)
	PA3140	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (109 aa)
	pilB	Type 4 fimbrial biogenesis protein PilB; Involved in the translocation of the type IV pilin (PilA); Belongs to the GSP E family. (566 aa)
	pilD	Type 4 prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the pilin precursor during membrane translocation. Required for the assembly of type IV pili and for secretion of most proteins. (290 aa)
	pilS	Two-component sensor PilS; Member of the two-component regulatory system PilS/PilR involved in the regulation of the expression of type 4 fimbriae. PilS may function as a membrane-associated protein kinase that phosphorylates PilR in response to environmental signals. (530 aa)
	pilR	Two-component response regulator PilR; Member of the two-component regulatory system PilS/PilR that regulates the expression of type 4 fimbriae. When activated by PilS it acts in conjunction with sigma-54 as a transcriptional activator. (445 aa)
	pilQ	Type 4 fimbrial biogenesis outer membrane protein PilQ precursor; Essential for the formation of pili. Involved in the biogenesis of type 4 fimbriae probably by serving as a 'porthole' allowing passage of the fimbrae through the outer membrane; Belongs to the bacterial secretin family. PilQ subfamily. (714 aa)
	pilP	Type 4 fimbrial biogenesis protein PilP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (174 aa)
	pilO	Type 4 fimbrial biogenesis protein PilO; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (207 aa)
	pilN	Type 4 fimbrial biogenesis protein PilN; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (198 aa)
	pilM	Type 4 fimbrial biogenesis protein PilM; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (354 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PA3140	pilB	PA3140	PA4526	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Type 4 fimbrial biogenesis protein PilB; Involved in the translocation of the type IV pilin (PilA); Belongs to the GSP E family.	0.469
PA3140	pilD	PA3140	PA4528	Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences).	Type 4 prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the pilin precursor during membrane translocation. Required for the assembly of type IV pili and for secretion of most proteins.	0.717
PA5498	pilB	PA5498	PA4526	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 fimbrial biogenesis protein PilB; Involved in the translocation of the type IV pilin (PilA); Belongs to the GSP E family.	0.497
PA5498	pilD	PA5498	PA4528	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 prepilin peptidase PilD; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue. Processes the pilin precursor during membrane translocation. Required for the assembly of type IV pili and for secretion of most proteins.	0.499
PA5498	pilJ	PA5498	PA0411	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Twitching motility protein PilJ; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	0.495
PA5498	pilT	PA5498	PA0395	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Twitching motility protein PilT; May be involved in pilus retraction; Belongs to the GSP E family.	0.703
PA5498	pilU	PA5498	PA0396	Probable adhesin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Twitching motility protein PilU; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.425
chpB	chpC	PA0414	PA0415	Probable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	0.987
chpB	pilG	PA0414	PA0408	Probable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Twitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions.	0.896
chpB	pilH	PA0414	PA0409	Probable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	0.907
chpB	pilJ	PA0414	PA0411	Probable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Twitching motility protein PilJ; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	0.999
chpB	pilR	PA0414	PA4547	Probable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	Two-component response regulator PilR; Member of the two-component regulatory system PilS/PilR that regulates the expression of type 4 fimbriae. When activated by PilS it acts in conjunction with sigma-54 as a transcriptional activator.	0.430
chpC	chpB	PA0415	PA0414	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Probable methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.	0.987
chpC	pilG	PA0415	PA0408	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Twitching motility protein PilG; Is involved in pilus biosynthesis and twitching motility. May act as a single-domain response regulator whose function may be to receive a certain environmental signal(s) and then transduce that signal to the pilus assembly machinery via specific protein-protein interactions.	0.995
chpC	pilH	PA0415	PA0409	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Twitching motility protein PilH; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	0.996
chpC	pilJ	PA0415	PA0411	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Twitching motility protein PilJ; May be a part of a signal-transduction system that regulates twitching motility by controlling pilus function (extension and retraction).	0.997
chpC	pilM	PA0415	PA5044	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 fimbrial biogenesis protein PilM; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.590
chpC	pilN	PA0415	PA5043	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 fimbrial biogenesis protein PilN; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.424
chpC	pilO	PA0415	PA5042	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 fimbrial biogenesis protein PilO; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.437
chpC	pilP	PA0415	PA5041	Probable chemotaxis protein; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene).	Type 4 fimbrial biogenesis protein PilP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.563