15 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Edges represent protein-protein associations

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Your Input:
	lpxA	UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (258 aa)
	PA3853	Probable transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (229 aa)
	bfmR	BfmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (246 aa)
	ftsI	Penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin. (579 aa)
	lpxC	UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (303 aa)
	bfmS	BfmS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (434 aa)
	parC	Topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (754 aa)
	pmrB	PmrB: two-component regulator system signal sensor kinase PmrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (477 aa)
	pmrA	PmrA: two-component regulator system response regulator PmrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (221 aa)
	phoP	Two-component response regulator PhoP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (225 aa)
	phoQ	Two-component sensor PhoQ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (448 aa)
	lipH	Lipase modulator protein; May be involved in the folding of the extracellular lipase during its passage through the periplasm; Belongs to the lipase chaperone family. (288 aa)
	gyrA	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (923 aa)
	recA	RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (346 aa)
	lpxD	UDP-3-O-[3-hydroxylauroyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (353 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
bfmR	bfmS	PA4101	PA4102	BfmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	BfmS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.999
bfmR	phoQ	PA4101	PA1180	BfmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	Two-component sensor PhoQ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.548
bfmR	pmrA	PA4101	PA4776	BfmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	PmrA: two-component regulator system response regulator PmrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.466
bfmR	pmrB	PA4101	PA4777	BfmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	PmrB: two-component regulator system signal sensor kinase PmrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.863
bfmS	bfmR	PA4102	PA4101	BfmS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	BfmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	0.999
bfmS	phoP	PA4102	PA1179	BfmS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	Two-component response regulator PhoP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.583
bfmS	pmrA	PA4102	PA4776	BfmS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	PmrA: two-component regulator system response regulator PmrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.799
bfmS	pmrB	PA4102	PA4777	BfmS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa.	PmrB: two-component regulator system signal sensor kinase PmrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.432
ftsI	gyrA	PA4418	PA3168	Penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin.	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	0.736
ftsI	lpxC	PA4418	PA4406	Penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin.	UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.	0.649
ftsI	parC	PA4418	PA4964	Penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin.	Topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.	0.609
ftsI	pmrB	PA4418	PA4777	Penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin.	PmrB: two-component regulator system signal sensor kinase PmrB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.446
gyrA	ftsI	PA3168	PA4418	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Penicillin-binding protein 3; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum (By similarity). Binds penicillin.	0.736
gyrA	lpxA	PA3168	PA3644	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	UDP-N-acetylglucosamine acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.	0.578
gyrA	lpxC	PA3168	PA4406	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	UDP-3-O-acyl-N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family.	0.627
gyrA	lpxD	PA3168	PA3646	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	UDP-3-O-[3-hydroxylauroyl] glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily.	0.558
gyrA	parC	PA3168	PA4964	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily.	0.849
gyrA	phoP	PA3168	PA1179	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Two-component response regulator PhoP; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.434
gyrA	phoQ	PA3168	PA1180	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	Two-component sensor PhoQ; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.524
gyrA	pmrA	PA3168	PA4776	DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.	PmrA: two-component regulator system response regulator PmrA; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.603