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rpoN rpoN rpoD rpoD algU algU gacS gacS pqsA pqsA pqsB pqsB pqsC pqsC pqsD pqsD flgD flgD flgE flgE flgK flgK fliC fliC fliD fliD fleQ fleQ fleS fleS fleR fleR toxA toxA lasR lasR fliP fliP fliR fliR fleN fleN fliA fliA anr anr kdpD kdpD kdpE kdpE lasA lasA ercS ercS ercS-2 ercS-2 gacA gacA pelA pelA flgM flgM rpoS rpoS narL narL ladS ladS bfmR bfmR bfmS bfmS bfiR bfiR bfiS bfiS pilS pilS pilR pilR fur fur retS retS algR algR mifR mifR mifS mifS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rpoNRNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (497 aa)
rpoDSigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (617 aa)
algUSigma factor AlgU; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor regulates genes such as algD, involved in alginate biosynthesis. (193 aa)
gacSSensor/response regulator hybrid; Product name confidence: Class 2 (High similarity to functionally studied protein). (925 aa)
pqsAProbable coenzyme A ligase; Catalyzes the formation of anthraniloyl-CoA, which is the priming step for entry into the Pseudomonas quinolone signal (PQS) biosynthetic pathway. Also active on a variety of aromatic substrates, including benzoate and chloro and fluoro derivatives of anthranilate. (517 aa)
pqsBPqsB; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. PqsB, together with PqsC, catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and resulting in closure of the quinoline ring. PqsB is probably required for the proper folding of PqsC ra [...] (283 aa)
pqsCPqsC; Required for the biosynthesis of the quorum-sensing signaling molecules 2-heptyl-4(1H)-quinolone (HHQ) and 2-heptyl-3-hydroxy-4(1H)- quinolone (Pseudomonas quinolone signal or PQS), which are important for biofilm formation and virulence. The PqsC/PqsB complex catalyzes the condensation of 2-aminobenzoylacetate (2-ABA) and octanoyl-CoA to form HHQ. First, PqsC acquires an octanoyl group from octanoyl-CoA and forms an octanoyl-PqsC intermediate. Then, together with PqsB, it catalyzes the coupling of 2-ABA with the octanoate group, leading to decarboxylation and dehydration, and re [...] (348 aa)
pqsD3-oxoacyl-[acyl-carrier-protein] synthase III; Required for the biosynthesis of a number of signaling molecules, such as the quinolone signal 2-heptyl-3-hydroxy-4(1H)- quinolone (PQS), 2-heptyl-4-hydroxyquinoline (HHQ) and 2,4- dihydroxyquinoline (DHQ). These molecules are required for normal biofilm formation. Catalyzes the transfer of the anthraniloyl moiety from anthraniloyl-CoA to malonyl-CoA to form 2-aminobenzoylacetyl-CoA. The first step of the reaction is the formation of a covalent anthraniloyl-PqsD intermediate. Next, the short-lived intermediate 3-(2-aminophenyl)- 3-oxopropa [...] (337 aa)
flgDFlagellar basal-body rod modification protein FlgD; Required for flagellar hook formation. May act as a scaffolding protein. (237 aa)
flgEFlagellar hook protein FlgE; Product name confidence: Class 2 (High similarity to functionally studied protein). (462 aa)
flgKFlagellar hook-associated protein 1 FlgK; Product name confidence: Class 2 (High similarity to functionally studied protein). (683 aa)
fliCFlagellin type B; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (488 aa)
fliDFlagellar capping protein FliD; Required for the morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. Essential for motility. Responsible for adhesion to mucin, which is the initial event in colonization by this organism of the airways of cystic fibrosis patients. (474 aa)
fleQTranscriptional regulator FleQ; AAA+ ATPase enhancer-binding protein that acts as a transcription regulator and plays a role in the modulation of mucin adhesion and flagellar gene expression. In addition to flagella genes, regulates also expression of biofilm-related genes. Functions as a transcriptional repressor in the absence of c-di-GMP and as an activator when c-di-GMP is present. (490 aa)
fleSTwo-component sensor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (402 aa)
fleRTwo-component response regulator; Plays a role in the regulation of both flagellar synthesis and adhesion to mucin. (473 aa)
toxAExotoxin A precursor; An NAD-dependent ADP-ribosyltransferase (ADPRT). Catalyzes the transfer of the ADP ribosyl moiety of oxidized NAD (NAD(+)) onto eukaryotic elongation factor 2 (eEF-2) thus arresting protein synthesis. Has an LD(50) of 65 ng/ml against the human lung epithelial cell line C38. (638 aa)
lasRTranscriptional regulator LasR; Transcriptional activator of elastase structural gene (LasB). Binds to the PAI autoinducer; Belongs to the autoinducer-regulated transcriptional regulatory protein family. (239 aa)
fliPFlagellar biosynthetic protein FliP; Plays a role in the flagellum-specific transport system. Belongs to the FliP/MopC/SpaP family. (255 aa)
fliRFlagellar biosynthetic protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (258 aa)
fleNFlagellar synthesis regulator FleN; ATPase that plays an important role in maintaining flagellar number in Pseudomonas aeruginosa. Exhibits anti-activator activity against FleQ, the global transcriptional regulator of flagellar genes ; Belongs to the ParA family. (280 aa)
fliASigma factor FliA; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor controls the expression of flagella-related genes (By similarity). Required for the flagellin gene (fliC) expression; Belongs to the sigma-70 factor family. FliA subfamily. (247 aa)
anrTranscriptional regulator Anr; Transcriptional activator of anaerobic gene expression. (244 aa)
kdpDTwo-component sensor KdpD; Product name confidence: Class 2 (High similarity to functionally studied protein). (885 aa)
kdpETwo-component response regulator KdpE; Product name confidence: Class 2 (High similarity to functionally studied protein). (230 aa)
lasALasA protease precursor; Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly- Gly-|-X substrates where X is Ala or Gly. Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases. Degradation of host elastin is likely to contribute to the pathogenicity of P.aeruginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a [...] (418 aa)
ercSErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (881 aa)
ercS-2ErcS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (564 aa)
gacAResponse regulator GacA; Positively controls the production of the autoinducer N- butyryl-homoserine lactone and the formation of the virulence factors pyocyanine, cyanide, and lipase. (214 aa)
pelAPelA; Class 1: Function experimentally demonstrated in P. aeruginosa. (948 aa)
flgMFlgM; Class 1: Function experimentally demonstrated in P. aeruginosa. (107 aa)
rpoSSigma factor RpoS; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response. (334 aa)
narLTwo-component response regulator NarL; Product name confidence: Class 2 (High similarity to functionally studied protein). (219 aa)
ladSLost Adherence Sensor, LadS; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (795 aa)
bfmRBfmR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (246 aa)
bfmSBfmS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (434 aa)
bfiRBfiR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (214 aa)
bfiSBfiS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (758 aa)
pilSTwo-component sensor PilS; Member of the two-component regulatory system PilS/PilR involved in the regulation of the expression of type 4 fimbriae. PilS may function as a membrane-associated protein kinase that phosphorylates PilR in response to environmental signals. (530 aa)
pilRTwo-component response regulator PilR; Member of the two-component regulatory system PilS/PilR that regulates the expression of type 4 fimbriae. When activated by PilS it acts in conjunction with sigma-54 as a transcriptional activator. (445 aa)
furFerric uptake regulation protein; Fur acts as a repressor, employing Fe(2+) as a cofactor to bind the operator of the iron transport operon. Involved in exotoxin A regulation, siderophore regulation and manganese susceptibility. (134 aa)
retSRetS (Regulator of Exopolysaccharide and Type III Secretion); Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (942 aa)
algRAlginate biosynthesis regulatory protein AlgR; Positive regulator of the algD gene, which codes for a GDP- mannose dehydrogenase, a key step enzyme in the alginate biosynthesis pathway. (248 aa)
mifRMifR; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (447 aa)
mifSMifS; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (588 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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