12 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	lasB	Elastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections. (498 aa)
	exoT	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (457 aa)
	tse7	Hypothetical protein; Type VI secretion exported toxin that via to its DNase activity induces growth arrest and ultimately DNA degradation within target cell. The activity is initially neutralized by a cognate immunity protein Tsi7. (386 aa)
	cat	Chloramphenicol acetyltransferase; This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm. (212 aa)
	fosA	Probable fosfomycin resistance protein; Metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin. (135 aa)
	aprA	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family. (479 aa)
	tse1	Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via amidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi1 that specifically interacts with and inactivates cognate toxin. (154 aa)
	exoY	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (378 aa)
	tse5	Conserved hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system that acts on bacterial target cells. The producing bacterium is protected by a cognate immunity protein. (1317 aa)
	tse2	Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the cytoplasm of recipient cells. Acts likely as a NAD-dependent cytotoxin towards both prokaryotic and eukaryotic cells. (158 aa)
	tse3	Hypothetical protein; Toxin secreted by the H1 type VI (H1-T6SS) secretion system into the periplasm of recipient cells. Degrades peptidoglycan via muramidase activity thereby helping itself to compete with other bacteria. To protect itself, the bacterium synthesizes immunity protein Tsi3 that specifically interacts with and inactivates cognate toxin. (408 aa)
	exoS	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (453 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
aprA	exoS	PA1249	PA3841	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.833
aprA	exoT	PA1249	PA0044	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.807
aprA	exoY	PA1249	PA2191	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.769
aprA	lasB	PA1249	PA3724	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.	Elastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections.	0.918
cat	exoS	PA0706	PA3841	Chloramphenicol acetyltransferase; This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm.	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.416
cat	exoT	PA0706	PA0044	Chloramphenicol acetyltransferase; This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm.	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.414
cat	fosA	PA0706	PA1129	Chloramphenicol acetyltransferase; This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm.	Probable fosfomycin resistance protein; Metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin.	0.885
exoS	aprA	PA3841	PA1249	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.	0.833
exoS	cat	PA3841	PA0706	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Chloramphenicol acetyltransferase; This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm.	0.416
exoS	exoT	PA3841	PA0044	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.907
exoS	exoY	PA3841	PA2191	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.959
exoS	fosA	PA3841	PA1129	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Probable fosfomycin resistance protein; Metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin.	0.418
exoS	lasB	PA3841	PA3724	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Elastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections.	0.883
exoT	aprA	PA0044	PA1249	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.	0.807
exoT	cat	PA0044	PA0706	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Chloramphenicol acetyltransferase; This enzyme is an effector of chloramphenicol (Cm) resistance in bacteria. Acetylates Cm but not 1-acetoxy-Cm.	0.414
exoT	exoS	PA0044	PA3841	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Exoenzyme S; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.907
exoT	exoY	PA0044	PA2191	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.964
exoT	fosA	PA0044	PA1129	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Probable fosfomycin resistance protein; Metalloglutathione transferase which confers resistance to fosfomycin by catalyzing the addition of glutathione to fosfomycin.	0.496
exoT	lasB	PA0044	PA3724	Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Elastase LasB; Cleaves host elastin, collagen, IgG, and several complement components as well as endogenous pro-aminopeptidase. Autocatalyses processing of its pro-peptide. Processes the pro-peptide of pro-chitin-binding protein (cbpD). Involved in the pathogenesis of P.aeruginosa infections.	0.882
exoY	aprA	PA2191	PA1249	Adenylate cyclase ExoY; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Alkaline metalloproteinase precursor; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the peptidase M10B family.	0.769