6 items (Pseudomonas aeruginosa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mtr	Tryptophan permease; Product name confidence: Class 2 (High similarity to functionally studied protein). (417 aa)
	phhA	Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (262 aa)
	phhR	Transcriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (519 aa)
	rpoN	RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (497 aa)
	phhC	Aromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. (399 aa)
	phhB	Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA. (118 aa)

Your Current Organism:

Pseudomonas aeruginosa

NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
mtr	phhB	PA5434	PA0871	Tryptophan permease; Product name confidence: Class 2 (High similarity to functionally studied protein).	Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA.	0.416
phhA	phhB	PA0872	PA0871	Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA.	0.999
phhA	phhC	PA0872	PA0870	Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	Aromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	0.999
phhA	phhR	PA0872	PA0873	Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	Transcriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.894
phhB	mtr	PA0871	PA5434	Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA.	Tryptophan permease; Product name confidence: Class 2 (High similarity to functionally studied protein).	0.416
phhB	phhA	PA0871	PA0872	Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA.	Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	0.999
phhB	phhC	PA0871	PA0870	Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA.	Aromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	0.997
phhB	phhR	PA0871	PA0873	Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA.	Transcriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.874
phhC	phhA	PA0870	PA0872	Aromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	0.999
phhC	phhB	PA0870	PA0871	Aromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA.	0.997
phhC	phhR	PA0870	PA0873	Aromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	Transcriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.813
phhR	phhA	PA0873	PA0872	Transcriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Phenylalanine-4-hydroxylase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.	0.894
phhR	phhB	PA0873	PA0871	Transcriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Pterin-4-alpha-carbinolamine dehydratase; Involved in tetrahydrobiopterin biosynthesis. Seems to both prevent the formation of 7-pterins and accelerate the formation of quinonoid-BH2. May also have a positive regulatory role in the expression of phhA.	0.874
phhR	phhC	PA0873	PA0870	Transcriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	Aromatic amino acid aminotransferase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.	0.813
phhR	rpoN	PA0873	PA4462	Transcriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	0.803
rpoN	phhR	PA4462	PA0873	RNA polymerase sigma-54 factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.	Transcriptional regulator PhhR; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa).	0.803