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fda fda PA2215 PA2215 pslB pslB mtlD mtlD mtlZ mtlZ algD algD alg8 alg8 alg44 alg44 algG algG algL algL algA algA fruA fruA fruK fruK tpiA tpiA fbp fbp algC algC wbpW wbpW gmd gmd rmd rmd
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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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fdaFructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family. (354 aa)
PA2215Hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences); Belongs to the mandelate racemase/muconate lactonizing enzyme family. (391 aa)
pslBPslB; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa; Belongs to the mannose-6-phosphate isomerase type 2 family. (488 aa)
mtlDMannitol dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the mannitol dehydrogenase family. (491 aa)
mtlZFructokinase; Product name confidence: Class 2 (High similarity to functionally studied protein). (310 aa)
algDGDP-mannose 6-dehydrogenase AlgD; Catalyzes the oxidation of guanosine diphospho-D-mannose (GDP-D-mannose) to GDP-D-mannuronic acid, a precursor for alginate polymerization. The alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. (436 aa)
alg8Alginate biosynthesis protein Alg8; Processive enzyme that polymerizes GDP-mannuronic acid. Belongs to the glycosyltransferase 2 family. (494 aa)
alg44Alginate biosynthesis protein Alg44; Required for alginate biosynthesis. Belongs to the Alg44 family. (389 aa)
algGAlginate-c5-mannuronan-epimerase AlgG; Catalyzes the epimerization of beta-D-mannuronate to alpha-L- guluronate during the synthesis of the linear polysaccharide alginate. In addition, is part of a periplasmic protein complex that protects alginate from degradation by AlgL by channeling the newly formed alginate polymer through a scaffold that transfers the alginate polymer through the periplasmic space to the outer membrane secretin AlgE. (543 aa)
algLPoly(beta-d-mannuronate) lyase precursor AlgL; Catalyzes the depolymerization of alginate by cleaving the beta-1,4 glycosidic bond between two adjacent sugar residues via a beta-elimination mechanism. May serve to degrade mislocalized alginate that is trapped in the periplasmic space. Acts preferentially on non-acetylated alginate or its precursor mannuronan. Is able to catalyze cleavage adjacent to either mannuronate or guluronate residues in alginate. Exhaustive digestion of alginate by AlgL generates dimeric and trimeric products. In addition to its enzymatic function, AlgL appears [...] (367 aa)
algAPhosphomannose isomerase / guanosine 5'-diphospho-D-mannose pyrophosphorylase; Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics; Belongs to the mannose-6-phosphate isomerase type 2 family. (481 aa)
fruAPhosphotransferase system transporter fructose-specific IIBC component, FruA; Product name confidence: Class 1: Function experimentally demonstrated in P. aeruginosa. (585 aa)
fruK1-phosphofructokinase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the carbohydrate kinase PfkB family. (314 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (251 aa)
fbpFructose-1,6-bisphosphatase; Product name confidence: Class 2 (High similarity to functionally studied protein). (336 aa)
algCPhosphomannomutase AlgC; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity. Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enzyme-phospho-Ser-1 [...] (463 aa)
wbpWPhosphomannose isomerase/GDP-mannose WbpW; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the mannose-6-phosphate isomerase type 2 family. (479 aa)
gmdGDP-mannose 4,6-dehydratase; Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6- deoxy-D-mannose. (323 aa)
rmdOxidoreductase Rmd; Reductase that catalyzes the conversion of GDP-6-deoxy-D- mannose to GDP-4-dehydro-6-deoxy-D-mannose (GDP-D-rhamnose). (304 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
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