STRINGSTRING
PA0134 PA0134 nuh nuh PA0148 PA0148 PA0387 PA0387 apaH apaH relA relA PA0935 PA0935 purN purN purM purM purC purC dgt dgt PA1140 PA1140 nrdB nrdB nrdA nrdA cysC cysC pykF pykF allA allA alc alc PA1518 PA1518 PA1521 PA1521 xdhB xdhB xdhA xdhA apt apt ppnP ppnP nrdD nrdD PA1931 PA1931 PA1932 PA1932 PA1933 PA1933 purB purB dgt2 dgt2 purF purF cyaB cyaB PA3516 PA3516 PA3517 PA3517 surE surE adk adk purT purT purL purL guaA guaA guaB guaB ndk ndk amn amn PA4115 PA4115 pykA pykA cysN cysN cysD cysD PA4645 PA4645 prs prs purH purH purD purD ureA ureA ureB ureB ureC ureC purA purA cpdA cpdA aspP aspP arcC arcC PA5176 PA5176 PA5177 PA5177 ppx ppx cyaA cyaA xpt xpt algC algC gmk gmk spoT spoT purK purK purE purE nrdJa nrdJa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PA0134Probable guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (456 aa)
nuhNonspecific ribonucleoside hydrolase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa); Belongs to the IUNH family. (350 aa)
PA0148Probable adenosine deaminase; Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. (316 aa)
PA0387Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (197 aa)
apaHBis(5'-nucleosyl)-tetraphosphatase; Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. (283 aa)
relAGTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (747 aa)
PA0935Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (276 aa)
purNPhosphoribosylaminoimidazole synthetase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (222 aa)
purMPhosphoribosylaminoimidazole synthetase; Product name confidence: Class 2 (High similarity to functionally studied protein). (353 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the SAICAR synthetase family. (236 aa)
dgtDeoxyguanosinetriphosphate triphosphohydrolase; dGTPase preferentially hydrolyzes dGTP over the other canonical NTPs. (498 aa)
PA1140Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (278 aa)
nrdBNrdB, tyrosyl radical-harboring component of class Ia ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (415 aa)
nrdANrdA, catalytic component of class Ia ribonucleotide reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (963 aa)
cysCAdenosine 5'-phosphosulfate (APS) kinase; Catalyzes the synthesis of activated sulfate. (196 aa)
pykFPyruvate kinase I; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the pyruvate kinase family. (477 aa)
allAUreidoglycolate hydrolaseYbbT; Catalyzes the catabolism of the allantoin degradation intermediate (S)-ureidoglycolate, generating urea and glyoxylate. Involved in the utilization of allantoin as nitrogen source. (169 aa)
alcAllantoicase; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the allantoicase family. (332 aa)
PA1518Conserved hypothetical protein; Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo- 4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily. (126 aa)
PA1521Probable guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (434 aa)
xdhBXanthine dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein). (799 aa)
xdhAXanthine dehydrogenase; Product name confidence: Class 2 (High similarity to functionally studied protein). (484 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (182 aa)
ppnPConserved hypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (93 aa)
nrdDClass III (anaerobic) ribonucleoside-triphosphate reductase subunit, NrdD; Class 2: Function of highly similar gene experimentally demonstrated in another organism (and gene context consistent in terms of pathways its involved in (if known). (675 aa)
PA1931Probable ferredoxin; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (170 aa)
PA1932Probable hydroxylase molybdopterin-containing subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (329 aa)
PA1933Probable hydroxylase large subunit; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (734 aa)
purBAdenylosuccinate lyase; Product name confidence: Class 2 (High similarity to functionally studied protein). (456 aa)
dgt2Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences); Belongs to the dGTPase family. Type 3 subfamily. (443 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (501 aa)
cyaBCyaB; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (463 aa)
PA3516Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (483 aa)
PA3517Probable lyase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (477 aa)
surESurvival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (249 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa)
purTPhosphoribosylglycinamide formyltransferase 2; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family. (393 aa)
purLPhosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. (1298 aa)
guaAGMP synthase; Catalyzes the synthesis of GMP from XMP. (525 aa)
guaBInosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (489 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. The 12-kDa membrane-associated form synthesizes GTP in preference to other nucleoside triphosphates. Important for alginate synthesis; Belongs to the NDK family. (143 aa)
amnAMP nucleosidase; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (499 aa)
PA4115Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (461 aa)
pykAPyruvate kinase II; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the pyruvate kinase family. (483 aa)
cysNATP sulfurylase GTP-binding subunit/APS kinase; ATP sulfurylase may be the GTPase, regulating ATP sulfurylase activity; In the N-terminal section; belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (633 aa)
cysDATP sulfurylase small subunit; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (305 aa)
PA4645Probable purine/pyrimidine phosphoribosyl transferase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (185 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (313 aa)
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Product name confidence: Class 2 (High similarity to functionally studied protein). (535 aa)
purDPhosphoribosylamine--glycine ligase; Product name confidence: Class 2 (High similarity to functionally studied protein). (429 aa)
ureAUrease gamma subunit; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the urease gamma subunit family. (100 aa)
ureBUrease beta subunit; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the urease beta subunit family. (101 aa)
ureCUrease alpha subunit; Product name confidence: Class 2 (High similarity to functionally studied protein); Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. (566 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (430 aa)
cpdACyclic AMP (cAMP) Phosphodiesterase, CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (272 aa)
aspPAdenosine diphosphate sugar pyrophosphatase; Product name confidence: Class 2 (High similarity to functionally studied protein). (205 aa)
arcCCarbamate kinase; Product name confidence: Class 1 (Function experimentally demonstrated in P. aeruginosa). (310 aa)
PA5176Conserved hypothetical protein; Product name confidence: Class 4 (Homologs of previously reported genes of unknown function, or no similarity to any previously reported sequences). (188 aa)
PA5177Probable hydrolase; Product name confidence: Class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene). (221 aa)
ppxExopolyphosphatase; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. Has also polyphosphate:ADP phosphotransferase activity, catalyzing the production of ATP from ADP and polyP. (506 aa)
cyaAAdenylate cyclase; Product name confidence: Class 2 (High similarity to functionally studied protein). (950 aa)
xptXanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. (190 aa)
algCPhosphomannomutase AlgC; Highly reversible phosphoryltransferase. The phosphomannomutase activity produces a precursor for alginate polymerization, the alginate layer causes a mucoid phenotype and provides a protective barrier against host immune defenses and antibiotics. Also involved in core lipopolysaccaride (LPS) biosynthesis due to its phosphoglucomutase activity. Essential for rhamnolipid production, an exoproduct correlated with pathogenicity. Required for biofilm production. The reaction proceeds via 2 processive phosphoryl transferase reactions; first from enzyme-phospho-Ser-1 [...] (463 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (203 aa)
spoTGuanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (701 aa)
purKPhosphoribosylaminoimidazole carboxylase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR); Belongs to the PurK/PurT family. (360 aa)
purEPhosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (163 aa)
nrdJaNrdJa; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (734 aa)
Your Current Organism:
Pseudomonas aeruginosa
NCBI taxonomy Id: 208964
Other names: P. aeruginosa PAO1, Pseudomonas aeruginosa PAO1, Pseudomonas sp. PAO1
Server load: low (10%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.