STRINGSTRING
AOD25612.1 AOD25612.1 pyrH pyrH AOD25630.1 AOD25630.1 trpS trpS thrS thrS tdk tdk dnaK dnaK AOD25655.1 AOD25655.1 dnaI dnaI oppF oppF oppD oppD metG metG gltX gltX AOD25268.1 AOD25268.1 AOD25278.1 AOD25278.1 ackA ackA nadD nadD AOD25306.1 AOD25306.1 pyrG pyrG asnC asnC AOD25320.1 AOD25320.1 ruvA ruvA ruvB ruvB pacL pacL metK metK gyrB gyrB cysS cysS dnaC dnaC leuS leuS atpD-1 atpD-1 atpG atpG atpA atpA recA recA adk adk glyS glyS gmk gmk AOD25227.1 AOD25227.1 AOD25451.1 AOD25451.1 pgk pgk uvrA uvrA AOD25485.1 AOD25485.1 potA potA proS proS AOD25503.1 AOD25503.1 smc smc AOD25526.1 AOD25526.1 nadE nadE gtp1 gtp1 lysS lysS hflB hflB tilS tilS alaS alaS AOD25559.1 AOD25559.1 pheT pheT oppA-2 oppA-2 uvrB uvrB AOD25684.1 AOD25684.1 atpD-2 atpD-2 AOD25687.1 AOD25687.1 nrdE nrdE AOD25703.1 AOD25703.1 AOD25704.1 AOD25704.1 AOD25705.1 AOD25705.1 vlpA vlpA valS valS bcrA bcrA AOD25040.1 AOD25040.1 dnaJ dnaJ mnmA mnmA AOD25052.1 AOD25052.1 AOD25053.1 AOD25053.1 AOD25054.1 AOD25054.1 AOD25074.1 AOD25074.1 cmk cmk AOD25084.1 AOD25084.1 tmcAL tmcAL grpE grpE argS argS AOD25107.1 AOD25107.1 dnaX dnaX tmk tmk cbiO cbiO ecfA ecfA gyrA gyrA tyrS tyrS prs prs gtsA gtsA parE parE parC parC ileS ileS hisS hisS aspS aspS AOD25159.1 AOD25159.1 AOD25160.1 AOD25160.1 serS serS AOD25172.1 AOD25172.1 AOD25185.1 AOD25185.1 AOD25193.1 AOD25193.1 malK malK AOD25210.1 AOD25210.1 AOD25211.1 AOD25211.1 AOD25212.1 AOD25212.1 oppD-1 oppD-1 AOD25226.1 AOD25226.1 pheS pheS AOD25565.1 AOD25565.1 pfkA pfkA clpB clpB AOD25586.1 AOD25586.1 secA secA gatB gatB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AOD25612.1ABC transporter, ATP-binding protein; Identified by sequence similarity; putative. (538 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (238 aa)
AOD25630.1Putative ATP-binding helicase; Identified by sequence similarity; putative. (1048 aa)
trpStryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (327 aa)
thrSThreonyl-tRNA synthetase; Identified by sequence similarity; putative; Belongs to the class-II aminoacyl-tRNA synthetase family. (581 aa)
tdkThymidine kinase; Identified by sequence similarity; putative. (192 aa)
dnaKHsp70-like protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. (597 aa)
AOD25655.1Putative ABC transporter ATP-binding protein p29; Identified by sequence similarity; putative. (252 aa)
dnaIPutative primosomal protein; Identified by sequence similarity; putative. (289 aa)
oppFOligopeptide transport system permease protein; Identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (767 aa)
oppDOligopeptide ABC transporter ATP binding prote; Identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (354 aa)
metGmethionyl-tRNA synthetase; Identified by sequence similarity; putative. (510 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (481 aa)
AOD25268.1ABC transporter ATP-binding protein; Identified by sequence similarity; putative. (311 aa)
AOD25278.1ABC transporter ATP-binding and permease protein; Identified by sequence similarity; putative. (676 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (402 aa)
nadDNicotinate (nicotinamide) nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (364 aa)
AOD25306.1Lipoate-protein ligase A; Identified by sequence similarity; putative. (346 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (545 aa)
asnCasparaginyl-tRNA synthetase; Identified by sequence similarity; putative. (446 aa)
AOD25320.1ATP-dependent helicase PcrA; Identified by sequence similarity; putative. (751 aa)
ruvAHolliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (213 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (317 aa)
pacLCation transporting P type ATPase; Identified by sequence similarity; putative. (899 aa)
metKS-adenosylmethionine synthetase; Identified by sequence similarity; putative; Belongs to the AdoMet synthase family. (380 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (640 aa)
cysSCysteinyl-tRNA synthetase; Identified by sequence similarity; putative. (400 aa)
dnaCReplicative helicase DnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (457 aa)
leuSleucyl-tRNA synthetase; Identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family. (788 aa)
atpD-1ATP synthase F1, beta subunit-1; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (470 aa)
atpGATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (282 aa)
atpAATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (508 aa)
recARecombinase protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (328 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (222 aa)
glySGlycyl-tRNA synthetase; Identified by sequence similarity; putative. (458 aa)
gmkGuanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP. (192 aa)
AOD25227.1Hypothetical protein. (2756 aa)
AOD25451.1Hypothetical protein; Identified by sequence similarity; putative; Expressed protein. (197 aa)
pgkPhosphoglycerate kinase; Identified by sequence similarity; putative; Belongs to the phosphoglycerate kinase family. (402 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (955 aa)
AOD25485.1ABC transporter, ATP-binding protein; Identified by sequence similarity; putative. (237 aa)
potASpermidine/putrescine ABC transporter ATP-binding protein; Identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (446 aa)
proSprolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (480 aa)
AOD25503.1TraE/TrsE-like membrane protein; Identified by sequence similarity; putative. (887 aa)
smcChromosome partition protein Smc; Required for chromosome condensation and partitioning. Belongs to the SMC family. (979 aa)
AOD25526.1Pyruvate kinase; Identified by sequence similarity; putative; Belongs to the pyruvate kinase family. (475 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source; Belongs to the NAD synthetase family. (243 aa)
gtp1Putative GTPase, putative translation factor; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (367 aa)
lysSlysyl-tRNA synthetase; Identified by sequence similarity; putative; Belongs to the class-II aminoacyl-tRNA synthetase family. (492 aa)
hflBATP-dependent metallopeptidase HflB; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (726 aa)
tilStRNA(Ile)-lysidine synthetase; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (292 aa)
alaSalanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (887 aa)
AOD25559.1Cytidyltransferase family protein; Identified by sequence similarity; putative. (290 aa)
pheTphenylalanyl-tRNA synthetase, beta subunit; Identified by sequence similarity; putative; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (728 aa)
oppA-2Oligopeptide ABC transporter, substrate-binding lipoprotein OppA; Identified by sequence similarity; putative. (946 aa)
uvrBExcinuclease ABC, B subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (653 aa)
AOD25684.1ABC transporter ATP-binding-Pr1 protein; Identified by sequence similarity; putative. (215 aa)
atpD-2ATP synthase F1, beta subunit-2; Identified by sequence similarity; putative. (464 aa)
AOD25687.1F0F1 ATP synthase subunit alpha; Identified by sequence similarity; putative. (507 aa)
nrdERibonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (721 aa)
AOD25703.1CLP-like protein; Identified by sequence similarity; putative. (332 aa)
AOD25704.1ATPase AAA2 domain protein; Identified by sequence similarity; putative. (45 aa)
AOD25705.1Hypothetical protein. (209 aa)
vlpAVariant surface antigen A; Identified by sequence similarity; putative. (233 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (824 aa)
bcrAABC-type multidrug-like transport system ATP-binding protein; Identified by sequence similarity; putative. (238 aa)
AOD25040.1ABC transporter, ATP-binding protein; Identified by sequence similarity; putative. (246 aa)
dnaJChaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] (372 aa)
mnmAtRNA-specific 2-thiouridylase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (370 aa)
AOD25052.1ABC transporter, ATP-binding and permease component; Identified by sequence similarity; putative. (536 aa)
AOD25053.1Putative transmembrane ATP-binding protein; Identified by sequence similarity; putative. (267 aa)
AOD25054.1ABC transporter ATP-binding protein; Identified by sequence similarity; putative. (262 aa)
AOD25074.1ATP-binding protein of ABC transporter; Identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (631 aa)
cmkCytidylate kinase; Identified by sequence similarity; putative. (222 aa)
AOD25084.1ABC transporter, ATP-binding protein; Identified by sequence similarity; putative. (512 aa)
tmcALUPF0348 protein family; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (304 aa)
grpEHeat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depen [...] (260 aa)
argSarginyl-tRNA synthetase; Identified by sequence similarity; putative. (533 aa)
AOD25107.1Lipoate-protein ligase A; Identified by sequence similarity; putative. (329 aa)
dnaXDNA polymerase III, subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (712 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (215 aa)
cbiOABC transporter, ATP-binding protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (266 aa)
ecfAABC transporter, ATP-binding protein; ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. (304 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (877 aa)
tyrSTyrosyl tRNA synthetase 1; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (418 aa)
prsRibose-phosphate pyrophosphokinase; Identified by sequence similarity; putative. (326 aa)
gtsAGlycerol ABC transporter, ATP bindingcomponent; Identified by sequence similarity; putative. (412 aa)
parEDNA topoisomerase IV subunit B; Identified by sequence similarity; putative. (649 aa)
parCDNA topoisomerase IV subunit A; Identified by sequence similarity; putative. (888 aa)
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (892 aa)
hisShistidyl-tRNA synthetase; Identified by sequence similarity; putative. (438 aa)
aspSaspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (573 aa)
AOD25159.1ABC transporter, ATP-binding/permease protein; Identified by sequence similarity; putative. (538 aa)
AOD25160.1ABC-type multidrug transport system, ATPase and permease component; Identified by sequence similarity; putative. (538 aa)
serSseryl-tRNA synthetase; Identified by sequence similarity; putative. (422 aa)
AOD25172.1ABC transporter, ATP-binding protein; Identified by sequence similarity; putative. (512 aa)
AOD25185.1Type III restriction enzyme, res subunit; Identified by sequence similarity; putative. (810 aa)
AOD25193.1AAA family ATPase; Identified by sequence similarity; putative. (349 aa)
malKMaltodextrin ABC transporter, ATP-binding protein; Identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (414 aa)
AOD25210.1ABC transporter, ATP-binding/permease protein; Identified by sequence similarity; putative. (528 aa)
AOD25211.1Transporter ATP-binding protein/permease; Identified by sequence similarity; putative. (193 aa)
AOD25212.1Putative ABC transporter ATP-binding - Pr2; Identified by sequence similarity; putative. (343 aa)
oppD-1Oligopeptide ABC transporter, ATP-binding protein; Identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (481 aa)
AOD25226.1Oligopeptide transport ATP-binding protein OppF; Identified by sequence similarity; putative; Belongs to the ABC transporter superfamily. (448 aa)
pheSphenylalanyl-tRNA synthetase subunit alpha; Identified by sequence similarity; putative; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (318 aa)
AOD25565.1Recombination factor protein RarA; Identified by sequence similarity; putative. (405 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (323 aa)
clpBATP-dependent chaperone ClpB; Identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. (703 aa)
AOD25586.1ATPase AAA; Identified by sequence similarity; putative. (864 aa)
secAPreprotein translocase, SecA subunit; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. (898 aa)
gatBAsp-tRNAAsn/Glu-tRNAGln amidotransferase B subunit; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (474 aa)
Your Current Organism:
Mycoplasma hyorhinis
NCBI taxonomy Id: 2100
Other names: ATCC 17981, ATCC 23234, Asterococcus hyorhinis, CIP 104968, DSM 25591, IFO 14858, M. hyorhinis, NBRC 14858, NCTC 10130, strain BTS 7, strain BTS-7, strain BTS7, strain PG42
Server load: low (26%) [HD]