STRINGSTRING
SMU_125 SMU_125 SMU_1390 SMU_1390 SMU_179 SMU_179 urdA urdA SMU_651c SMU_651c SMU_652c SMU_652c SMU_653c SMU_653c
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
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Known Interactions
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experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
SMU_125Conserved hypothetical protein; Best Blastp Hit: emb|CAB62679.1| (AL133422) putative secreted protein. [Streptomyces coelicolor A3(2)]. (184 aa)
SMU_1390Conserved hypothetical protein; Best Blastp Hit: pir||T36692 probable integral membrane regulator - Streptomyces coelicolor >gi|4726002|emb|CAB41731.1| (AL049731) putative integral membrane regulator [Streptomyces coelicolor A3(2)]. (218 aa)
SMU_179Conserved hypothetical protein; Best Blastp Hit: gb|AAG18632.1| (AY007504) unknown [Streptococcus mitis]. (200 aa)
urdAPutative oxidoreductase; Catalyzes the two-electron reduction of urocanate to dihydrourocanate (also named imidazole propionate or deamino- histidine). Dihydrourocanate is present at higher concentrations in subjects with type 2 diabetes, and directly impairs glucose tolerance and insulin signaling at the level of insulin receptor substrate (IRS) through activation of p38 gamma (MAPK12)-p62-mTORC1. Therefore, the UrdA enzyme from the gut bacteria S.mutans strain UA159 may contribute to the pathogenesis of type 2 diabetes by producing the microbial metabolite dihydrourocanate. (803 aa)
SMU_651cPutative ABC transporter, substrate-binding protein; Best Blastp Hit: gb|AAG05982.1|AE004688_4 (AE004688) conserved hypothetical protein [Pseudomonas aeruginosa]. (342 aa)
SMU_652cBest Blastp Hit: sp|Q57855|Y412_METJA HYPOTHETICAL ABC TRANSPORTER ATP-BINDING PROTEIN MJ0412 >gi|2129162|pir||D64351 nitrate transport ATP-binding protein - Methanococcus jannaschii >gi|1591118|gb|AAB98401.1| (U67493) nitrate transporter protein (nrtC) homolog (cmpC) [Methanococcus jannaschii]. (249 aa)
SMU_653cPutative ABC transporter, permease protein; Best Blastp Hit: sp|P40401|SSUC_BACSU PUTATIVE ALIPHATIC SULFONATES TRANSPORT PERMEASE PROTEIN SSUC >gi|2127179|pir||I39928 nitrate transport protein nrtB homolog ygaM - Bacillus subtilis >gi|438473|gb|AAA64349.1| (L16808) protein is hydrophobic, with homology to E. coli ProW; putative [Bacillus subtilis] >gi|1903040|emb|CAB07522.1| (Z93102) hypothetical 30.2 kd protein [Bacillus subtilis] >gi|2633208|emb|CAB12713.1| (Z99108) alternate gene name: yzeB similar to ABC transporter (permease) [Bacillus subtilis]. (328 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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