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| | dnaN | Putative DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for init [...] (378 aa) |
| | SMU_05 | Conserved hypothetical protein; Best Blastp Hit: gb|AAC45338.1| (AF000658) ORFX [Streptococcus pneumoniae]. (63 aa) |
| | ychF | Putative GTP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (371 aa) |
| | pth | Putative peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (189 aa) |
| | trcF | Putative transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1162 aa) |
| | SMU_09 | Conserved hypothetical protein; Best Blastp Hit: sp|P37557|YABO_BACSU HYPOTHETICAL 9.7 KDA PROTEIN IN MFD-DIVIC INTERGENIC REGION >gi|2127042|pir||S66089 conserved hypothetical protein yabO - Bacillus subtilis >gi|467448|dbj|BAA05294.1| (D26185) unknown [Bacillus subtilis] >gi|2632326|emb|CAB11835.1| (Z99104) similar to hypothetical proteins [Bacillus subtilis]. (90 aa) |
| | topA | Putative DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing [...] (705 aa) |
| | SMU_1044c | Putative pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (296 aa) |
| | SMU_1046c | Putative GTP pyrophosphokinase; Best Blastp Hit: dbj|BAB06568.1| (AP001516) GTP pyrophosphokinase [Bacillus halodurans]. (221 aa) |
| | ffh | Signal recognition particle protein subunit, Ffh; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. (516 aa) |
| | SMU_11 | Best Blastp Hit: pir||T16171 hypothetical protein F26F4.8 - Caenorhabditis elegans >gi|529206|gb|AAA91223.1| (U12964) contains zinc finger-like regions [Caenorhabditis elegans]. (39 aa) |
| | gyrA | DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (825 aa) |
| | rs20 | Putative 30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (84 aa) |
| | pcrA | ATP-dependent DNA helicase; Best Blastp Hit: sp|O34580|PCRA_BACSU ATP-DEPENDENT DNA HELICASE PCRA >gi|7436413|pir||E69794 ATP-dependent DNA helicase homolog yerF - Bacillus subtilis >gi|2577965|emb|CAA75552.1| (Y15254) PcrA protein [Bacillus subtilis] >gi|2632975|emb|CAB12481.1| (Z99107) similar to ATP-dependent DNA helicase [Bacillus subtilis]. (733 aa) |
| | lepB | Putative signal peptidase; Best Blastp Hit: sp|P41027|LEPC_BACCL SIGNAL PEPTIDASE I (SPASE I) (LEADER PEPTIDASE I) >gi|2126774|pir||I40175 signal peptidase I (EC 3.4.21.89) - Bacillus caldolyticus >gi|451875|gb|AAA22759.1| (L26257) signal peptidase I [Bacillus caldolyticus] >gi|809656|emb|CAA81813.1| (Z27457) signal peptidase I [Bacillus caldolyticus]; Belongs to the peptidase S26 family. (184 aa) |
| | dnaE | DNA polymerase III, alpha chain; Best Blastp Hit: gb|AAF98350.1| (AF280766) DNA polymerase III alpha subunit [Streptococcus pyogenes]. (1034 aa) |
| | SMU_12 | Conserved hypothetical protein; Best Blastp Hit: pir||I39830 penicillin binding protein 5 - Bacillus subtilis (fragment) >gi|142817|gb|AAA22375.1| (M13766) penicillin binding protein 5 [Bacillus subtilis]. (404 aa) |
| | rpmB | 50S ribosomal protein L28; Best Blastp Hit: dbj|BAB06219.1| (AP001515) ribosomal protein L28 [Bacillus halodurans]; Belongs to the bacterial ribosomal protein bL28 family. (62 aa) |
| | rs1 | Best Blastp Hit: sp|P50889|RS1_LEULA 40S RIBOSOMAL PROTEIN S1 >gi|1565296|gb|AAB08978.1| (U24086) ribosomal protein S1 homolog; sequence specific DNA-binding protein [Leuconostoc lactis]. (399 aa) |
| | parC | Topoisomerase IV, subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily. (818 aa) |
| | parE | Putative DNA topoisomerase IV, subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 2 subfamily. (649 aa) |
| | nylA | Putative amidase; Best Blastp Hit: pir||C75543 6-aminohexanoate-cyclic-dimer hydrolase - Deinococcus radiodurans (strain R1) >gi|6457907|gb|AAF09821.1|AE001885_5 (AE001885) 6-aminohexanoate-cyclic-dimer hydrolase [Deinococcus radiodurans]; Belongs to the amidase family. (480 aa) |
| | SMU_1220c | Best Blastp Hit: pir||E70080 conserved hypothetical protein yxkA - Bacillus subtilis >gi|1783240|dbj|BAA11717.1| (D83026) hypothetical [Bacillus subtilis] >gi|2636422|emb|CAB15913.1| (Z99123) similar to hypothetical proteins [Bacillus subtilis]. (166 aa) |
| | polC | DNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1465 aa) |
| | uvrC | Putative excinuclease ABC (subunit C); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (595 aa) |
| | gyrB | Putative DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (650 aa) |
| | rl19 | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. (115 aa) |
| | rl31 | 50S ribosomal protein L31; Best Blastp Hit: gb|AAF80389.1|AF160251_3 (AF160251) ribosomal protein L31 [Listeria innocua]; Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily. (80 aa) |
| | tilS | Putative cell-cycle protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (423 aa) |
| | asnS | Best Blastp Hit: sp|P39772|SYN_BACSU ASPARAGINYL-TRNA SYNTHETASE (ASPARAGINE--TRNA LIGASE) (ASNRS) >gi|7437578|pir||B69591 asparagine--tRNA ligase (EC 6.1.1.22) asnS - Bacillus subtilis >gi|1146247|gb|AAB38455.1| (L47709) asparaginyl-tRNA synthetase [Bacillus subtilis] >gi|2634654|emb|CAB14152.1| (Z99115) asparaginyl-tRNA synthetase [Bacillus subtilis]. (448 aa) |
| | dinG | Putative ATP-dependent DNA helicase; 3'-5' exonuclease. (820 aa) |
| | rf2 | Putative peptide chain release factor (RF-2); Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (325 aa) |
| | SMU_1388 | Best Blastp Hit: pir||C69813 RNA helicase homolog yfmL - Bacillus subtilis >gi|2443255|dbj|BAA22326.1| (D86417) YfmL [Bacillus subtilis] >gi|2633067|emb|CAB12572.1| (Z99108) similar to RNA helicase [Bacillus subtilis]. (360 aa) |
| | lepA | Putative GTP-binding protein; Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre- translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP- dependent manner. (611 aa) |
| | hprT | Best Blastp Hit: sp|Q02522|HPRT_LACLA HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) (HGPRTASE) >gi|418760|pir||S30100 hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) - Lactococcus lactis >gi|44026|emb|CAA48876.1| (X69123) hypoxanthine guanine phosphoribosyltransferase [Lactococcus lactis] >gi|49105|emb|CAA47404.1| (X67015) hypoxanthine phosphoribosyltransferase [Lactococcus lactis] >gi|384297|prf||1905381A hypoxanthine guanine phosphoribosyltransferase [Lactococcus lactis]. (180 aa) |
| | SMU_1431c | Best Blastp Hit: dbj|BAB04269.1| (AP001508) ABC transporter (ATP-binding protein) [Bacillus halodurans]. (637 aa) |
| | def | Putative polypeptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. (204 aa) |
| | rnj | Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (554 aa) |
| | SMU_1449 | Putative fibronectin/fibrinogen-binding protein; Best Blastp Hit: emb|CAA46282.1| (X65164) fibronectin-binding protein-like, protein A [Streptococcus gordonii]. (549 aa) |
| | ftsH | Putative cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (656 aa) |
| | SMU_1505c | Hypothetical protein; Best Blastp Hit: emb|CAA37225.1| (X53057) phenylalanyl-tRNA synthetase beta subunit (AA 1-804) [Bacillus subtilis]. (39 aa) |
| | syfB | Putative phenylalanyl-tRNA synthetase (beta subunit); Best Blastp Hit: sp|P17922|SYFB_BACSU PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (PHENYLALANINE--TRNA LIGASE BETA CHAIN) (PHERS) >gi|7428487|pir||YFBSB phenylalanine--tRNA ligase (EC 6.1.1.20) beta chain - Bacillus subtilis >gi|1770031|emb|CAA99564.1| (Z75208) phenylalanyl-tRNA synthetase beta subunit [Bacillus subtilis] >gi|2635328|emb|CAB14823.1| (Z99118) phenylalanyl-tRNA synthetase (beta subunit) [Bacillus subtilis]. (801 aa) |
| | SMU_1511c | Putative acetyltransferase; Best Blastp Hit: sp|P21340|PAIA_BACSU PROTEASE SYNTHASE AND SPORULATION NEGATIVE REGULATORY PROTEIN PAI 1 >gi|2635712|emb|CAB15205.1| (Z99120) transcriptional regulator [Bacillus subtilis]. (173 aa) |
| | syfA | Putative phenylalanyl-tRNA synthetase (alpha subunit); Best Blastp Hit: sp|P17921|SYFA_BACSU PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (PHENYLALANINE--TRNA LIGASE ALPHA CHAIN) (PHERS) >gi|7428485|pir||YFBSA phenylalanine--tRNA ligase (EC 6.1.1.20) alpha chain - Bacillus subtilis >gi|1770030|emb|CAA99603.1| (Z75208) phenylalany-tRNA synthetase beta subunit [Bacillus subtilis] >gi|2635329|emb|CAB14824.1| (Z99118) phenylalanyl-tRNA synthetase (alpha subunit) [Bacillus subtilis]; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (347 aa) |
| | rnc | Putative ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity). Belongs to the ribonuclease III family. (231 aa) |
| | atpA | FoF1 membrane-bound proton-translocating ATPase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (138 aa) |
| | atpB | FoF1 membrane-bound proton-translocating ATPase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (468 aa) |
| | atpC | FoF1 membrane-bound proton-translocating ATPase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa) |
| | atpD | FoF1 membrane-bound proton-translocating ATPase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (501 aa) |
| | atpE | FoF1 membrane-bound proton-translocating ATPase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (178 aa) |
| | atpF | FoF1 membrane-bound proton-translocating ATPase, b subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (165 aa) |
| | atpG | FoF1 membrane-bound proton-translocating ATPase, a subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (239 aa) |
| | atpH | FoF1 membrane-bound proton-translocating ATPase, c subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (67 aa) |
| | rpsO | 30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa) |
| | dnlJ | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. (652 aa) |
| | dnaX | DNA polymerase III, gamma/tau subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (558 aa) |
| | syt1 | Putative threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (649 aa) |
| | SMU_1587c | Hypothetical protein; Best Blastp Hit: sp|O84130|KAD_CHLTR ADENYLATE KINASE (ATP-AMP TRANSPHOSPHORYLASE) >gi|7434610|pir||D71554 probable adenylate cyclase - Chlamydia trachomatis (serotype D, strain UW3/Cx) >gi|3328527|gb|AAC67719.1| (AE001286) adenylate kinase [Chlamydia trachomatis]. (212 aa) |
| | smpB | Putative SsrA-binding protein-like protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The rib [...] (155 aa) |
| | vacB | Putative exoribonuclease R (RNAase R); 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (778 aa) |
| | SMU_1609c | Putative membrane protein involved in protein secretion, SecG; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (78 aa) |
| | rl33 | Best Blastp Hit: sp|P23375|RL33_BACST 50S RIBOSOMAL PROTEIN L33 >gi|477793|pir||B48396 ribosomal protein L33 - Bacillus stearothermophilus >gi|240272|gb|AAB20569.1| BstL33=50S ribosomal subunit protein [Bacillus stearothermophilus, Peptide, 49 aa] >gi|243175|gb|AAB21086.1| ribosomal protein L33 [Bacillus stearothermophilus, Peptide, 49 aa] >gi|228174|prf||1718186B ribosomal protein L33 [Bacillus stearothermophilus]; Belongs to the bacterial ribosomal protein bL33 family. (48 aa) |
| | rrf1 | Putative ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | pyrH | Putative uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (245 aa) |
| | rl1 | 50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (229 aa) |
| | rl11 | 50S ribosomal L11 protein; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. (141 aa) |
| | ftsK | Putative cell division protein; Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the difSL recombination site, which is located within the replication terminus region. Required for activation of the XerS recombinase, allowing activation of chromosome unlinking by recombination (By similarity). Belongs to the FtsK/SpoIIIE/SftA family. (758 aa) |
| | SMU_1631 | Putative peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (258 aa) |
| | metS | Putative methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (669 aa) |
| | holB | Best Blastp Hit: sp|P37540|HOLB_BACSU DNA POLYMERASE III, DELTA' SUBUNIT >gi|2126931|pir||S66061 DNA polymerase III delta' chain holB - Bacillus subtilis >gi|467421|dbj|BAA05267.1| (D26185) similar to B. subtilis DnaH [Bacillus subtilis] >gi|2632298|emb|CAB11807.1| (Z99104) DNA polymerase III (delta' subunit) [Bacillus subtilis]. (291 aa) |
| | ppaC | Best Blastp Hit: sp|O68579|PPAC_STRMU PROBABLE MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE (PYROPHOSPHATE PHOSPHO-HYDROLASE) (PPASE) >gi|2952533|gb|AAC05778.1| (AF051356) putative exopolyphosphatase [Streptococcus mutans] >gi|3403205|gb|AAC29042.1| (AF050517) unknown [Streptococcus mutans]; Belongs to the PPase class C family. (310 aa) |
| | rplM | 50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (148 aa) |
| | rpsI | Best Blastp Hit: sp|P07842|RS9_BACST 30S RIBOSOMAL PROTEIN S9 (BS10) >gi|70924|pir||R3BS9 ribosomal protein S9 - Bacillus stearothermophilus; Belongs to the universal ribosomal protein uS9 family. (130 aa) |
| | SMU_1724c | Putative rRNA methylase; Best Blastp Hit: dbj|BAB06831.1| (AP001517) rRNA methylase [Bacillus halodurans]; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (246 aa) |
| | yidC2 | Putative inner membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity). Partially complements an E.coli yidC depletion experiment. (310 aa) |
| | greA | Putative transcription elongation factor GreA; Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. (160 aa) |
| | SMU_1733c | Putative SNF helicase; Best Blastp Hit: emb|CAA67095.1| (X98455) SNF [Bacillus cereus]. (1030 aa) |
| | syv | Putative valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (883 aa) |
| | proS | Putative prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and inv [...] (616 aa) |
| | SMU_1787c | Putative secreted protein; Best Blastp Hit: dbj|BAA11328.1| (D78257) ORF11 [Enterococcus faecalis]. (127 aa) |
| | gatB | Putative glutamyl-tRNA (Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (479 aa) |
| | gatA-2 | Putative glutamyl-tRNA(Gln) amidotransferase A subunit; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (488 aa) |
| | gatC | Putative glutamyl-tRNA (Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (100 aa) |
| | gatA | Putative aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (583 aa) |
| | recG | Putative ATP-dependent DNA helicase, RecG; Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y- DNA); Belongs to the helicase family. RecG subfamily. (671 aa) |
| | secA | Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (839 aa) |
| | efp | Putative translation elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (186 aa) |
| | uvrA | Putative excinuclease ABC (subunit A); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa) |
| | rs18 | 30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (79 aa) |
| | ssb | Putative single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (164 aa) |
| | rs6 | 30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (96 aa) |
| | mutS2 | Putative DNA mismatch repair protein MutS2; Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity; Belongs to the DNA mismatch repair MutS family. MutS2 subfamily. (776 aa) |
| | lepC | Best Blastp Hit: sp|O07344|LEP_STRPN SIGNAL PEPTIDASE I (SPASE I) (LEADER PEPTIDASE I) >gi|2149614|gb|AAB69116.1| (U90721) signal peptidase I [Streptococcus pneumoniae]; Belongs to the peptidase S26 family. (195 aa) |
| | sys | Putative seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | dnaI | Best Blastp Hit: sp|P06567|DNAI_BACSU PRIMOSOMAL PROTEIN DNAI >gi|279708|pir||IQBS44 primosome component (helicase loader) dnaI - Bacillus subtilis >gi|39881|emb|CAA28633.1| (X04963) ORF 311 (AA 1-311) [Bacillus subtilis] >gi|1769996|emb|CAA99605.1| (Z75208) replication protein [Bacillus subtilis] >gi|2293281|gb|AAC00359.1| (AF008220) DnaI [Bacillus subtilis] >gi|2635363|emb|CAB14858.1| (Z99118) helicase loader [Bacillus subtilis]. (299 aa) |
| | syl | Putative leucyl-tRNA synthetase; Best Blastp Hit: dbj|BAB07000.1| (AP001518) leucyl-tRNA synthetase [Bacillus halodurans]; Belongs to the class-I aminoacyl-tRNA synthetase family. (833 aa) |
| | nusG | Putative transcription antitermination factor; Participates in transcription elongation, termination and antitermination. (178 aa) |
| | secE | Putative preprotein translocase subunit SecE; Belongs to the SecE/SEC61-gamma family. (58 aa) |
| | SMU_1950 | Putative pseudouridylate synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (288 aa) |
| | ssb2 | Putative single-stranded DNA-binding protein; Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. (131 aa) |
| | rpoC | DNA-dependent RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1218 aa) |
| | rpoB | DNA-dependent RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1187 aa) |
| | tyrS | Putative tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (422 aa) |
| | rl17 | Best Blastp Hit: sp|P20277|RL17_BACSU 50S RIBOSOMAL PROTEIN L17 (BL15) (BL21) >gi|80370|pir||F32307 ribosomal protein L17 - Bacillus subtilis >gi|142464|gb|AAA22218.1| (M26414) ribosomal protein L17 [Bacillus subtilis] >gi|1044992|gb|AAB06827.1| (L47971) ribosomal protein L17 [Bacillus subtilis] >gi|2632411|emb|CAB11920.1| (Z99104) ribosomal protein L17 (BL15) [Bacillus subtilis]. (128 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa) |
| | rs11 | 30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (127 aa) |
| | rs13 | 30S ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites. Belongs to the universal ribosomal protein uS13 family. (121 aa) |
| | rpmJ | 50S ribosomal protein L36; Belongs to the bacterial ribosomal protein bL36 family. (38 aa) |
| | if1 | Putative translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | secY | Putative preprotein translocase SecY protein; The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. (434 aa) |
| | rl15 | 50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (146 aa) |
| | rl30 | Best Blastp Hit: sp|O06444|RL30_STAAU 50S RIBOSOMAL PROTEIN L30 >gi|2078380|gb|AAB54020.1| (U96620) ribosomal protein L30 [Staphylococcus aureus]. (60 aa) |
| | rs5 | 30S ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family. (164 aa) |
| | rl18 | 50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa) |
| | rl6 | 50S ribosomal protein L6 (BL10); This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (178 aa) |
| | rs8 | 30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa) |
| | rs14 | 30S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa) |
| | rl5 | 50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (180 aa) |
| | rl24 | 50S ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (101 aa) |
| | rl14 | 50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa) |
| | rs17 | 30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (86 aa) |
| | rl29 | Best Blastp Hit: sp|Q9WVW8|RL29_STRPN 50S RIBOSOMAL PROTEIN L29 >gi|4927748|gb|AAD33264.1|AF126059_5 (AF126059) RpL29 [Streptococcus pneumoniae] >gi|4927757|gb|AAD33273.1| (AF126060) RpL29 [Streptococcus pneumoniae] >gi|4927766|gb|AAD33282.1| (AF126061) RpL29 [Streptococcus pneumoniae]; Belongs to the universal ribosomal protein uL29 family. (69 aa) |
| | rl16 | 50S ribosomal protein L16; Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs; Belongs to the universal ribosomal protein uL16 family. (137 aa) |
| | rs3 | 30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (208 aa) |
| | rl22 | 50S ribosomal protein L22; This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity). (114 aa) |
| | rpsS | 30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa) |
| | rplD | 50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (207 aa) |
| | rl3 | 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (208 aa) |
| | rpsJ | 30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (36 aa) |
| | eftS | Putative translation elongation factor TS; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (348 aa) |
| | rs2 | Best Blastp Hit: sp|P49668|RS2_PEDAC 30S RIBOSOMAL PROTEIN S2 >gi|897795|emb|CAA50276.1| (X70925) 30S ribosomal protein [Pediococcus acidilactici]; Belongs to the universal ribosomal protein uS2 family. (261 aa) |
| | relA | Putative stringent response protein, ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (740 aa) |
| | recA | Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (383 aa) |
| | ruvA | Putative Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (197 aa) |
| | hexB | Putative mismatch repair protein HexB; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (651 aa) |
| | mutS | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (849 aa) |
| | argS | Putative arginyl-tRNA synthase; Best Blastp Hit: gb|AAF86984.1|AF282249_3 (AF282249) ArgS [Lactococcus lactis subsp. lactis]. (563 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (589 aa) |
| | hisS | Best Blastp Hit: sp|P30053|SYH_STREQ HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS) >gi|11271795|pir||S30233 histidine--tRNA ligase (EC 6.1.1.21) [validated] - Streptococcus equisimilis. (429 aa) |
| | rpmF | 50S ribosomal protein L32; Best Blastp Hit: gi|15903984|ref|NP_359534.1| (NC_003098) 50S Ribosomal protein L32 [Streptococcus pneumoniae R6]; Belongs to the bacterial ribosomal protein bL32 family. (60 aa) |
| | rpsD | 30S ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (203 aa) |
| | dnaC | Putative replicative DNA helicase (DNA polymerase III delta prime subunit); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (454 aa) |
| | rplI | 50S ribosomal protein L9; Binds to the 23S rRNA. (150 aa) |
| | trpS | Putative tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (340 aa) |
| | SMU_2159 | Best Blastp Hit: pir||E69861 ABC transporter (ATP-binding protein) homolog ykpA - Bacillus subtilis >gi|2633814|emb|CAB13316.1| (Z99111) similar to ABC transporter (ATP-binding protein) [Bacillus subtilis] >gi|3282128|gb|AAC24918.1| (AF012285) YkpA [Bacillus subtilis]. (539 aa) |
| | SMU_2165 | Putative SpoJ; Belongs to the ParB family. (257 aa) |
| | rplW | 50S Ribosomal Protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (99 aa) |
| | rplB | 50S Ribosomal Protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (279 aa) |
| | SMU_24 | Best Blastp Hit: gb|AAF06954.1|AF146529_1 (AF146529) aromatic amino acid aminotransferase [Lactococcus lactis subsp. cremoris]. (391 aa) |
| | recO | Putative DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (251 aa) |
| | polI | DNA polymerase I (POL I); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. (878 aa) |
| | gltX | Putative glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (485 aa) |
| | yidC1 | Conserved hypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity). Partially complements an E.coli yidC depletion experiment. (271 aa) |
| | rpmH | Best Blastp Hit: sp|P16498|RL34_PSEPU 50S RIBOSOMAL PROTEIN L34 >gi|71360|pir||R6PS34 ribosomal protein L34 - Pseudomonas putida >gi|45706|emb|CAA44414.1| (X62540) homologous to E.coli rpmH [Pseudomonas putida]; Belongs to the bacterial ribosomal protein bL34 family. (44 aa) |
| | rpsL | 30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. (137 aa) |
| | rpsG | 30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa) |
| | fusA | Translation elongation factor G (EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G [...] (693 aa) |
| | rnj-2 | Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (560 aa) |
| | SMU_383c | Conserved hypothetical protein; Best Blastp Hit: sp|P73212|DFRA_SYNY3 PUTATIVE DIHYDROFLAVONOL-4-REDUCTASE (DFR) (DIHYDROKAEMPFEROL 4-REDUCTASE) >gi|7469297|pir||S75325 dihydrokaempferol 4-reductase (EC 1.1.1.219) - Synechocystis sp. (strain PCC 6803) >gi|1652316|dbj|BAA17239.1| (D90904) dihydroflavonol 4-reductase [Synechocystis sp.]. (348 aa) |
| | SMU_394c | Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (99 aa) |
| | rimP | Conserved hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (163 aa) |
| | nusA | Putative transcription factor NusA; Participates in both transcription termination and antitermination. (397 aa) |
| | SMU_419 | Conserved hypothetical protein; Best Blastp Hit: sp|P32728|YLXR_BACSU HYPOTHETICAL 10.4 KD PROTEIN IN NUSA-INFB INTERGENIC REGION (ORF3) >gi|541414|pir||D36905 conserved hypothetical protein ylxR - Bacillus subtilis >gi|580900|emb|CAA79232.1| (Z18631) ORF3 [Bacillus subtilis] >gi|2634033|emb|CAB13534.1| (Z99112) alternate gene name: ymxB similar to hypothetical proteins [Bacillus subtilis]. (98 aa) |
| | SMU_420 | Putative ribosomal protein; Best Blastp Hit: sp|P55768|YLXQ_ENTFC PROBABLE RIBOSOMAL PROTEIN IN INFB 5'REGION. (100 aa) |
| | infB | Translation initiation factor 2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (916 aa) |
| | rbfA | Ribosome binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (116 aa) |
| | cshB | Putative ATP-dependent RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (447 aa) |
| | rny | Conserved hypothetical protein; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (535 aa) |
| | rpoZ | RNA polymerase-associated protein RpoZ, omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (105 aa) |
| | hpf | Putative ribosome-associated protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (182 aa) |
| | ileS | isoleucine-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (930 aa) |
| | recM | Putative recombination protein RecM; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (199 aa) |
| | prfC | Putative translation elongation and release factor; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (514 aa) |
| | cshA | Putative ATP-dependent RNA helicase, DEAD-box family; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (517 aa) |
| | SMU_628 | Conserved hypothetical protein; Best Blastp Hit: emb|CAA72898.1| (Y12224) hypothetical protein [Streptococcus agalactiae]. (346 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (344 aa) |
| | infC | Putative translation initiation factor IF3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (176 aa) |
| | rpmI | Best Blastp Hit: sp|P13069|RL35_BACST 50S RIBOSOMAL PROTEIN L35 >gi|71371|pir||R5BS35 ribosomal protein L35 - Bacillus stearothermophilus >gi|39962|emb|CAA34313.1| (X16188) ribosomal protein L35 (AA 1-66) [Bacillus stearothermophilus]; Belongs to the bacterial ribosomal protein bL35 family. (66 aa) |
| | rplT | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (119 aa) |
| | tuf | Translation elongation factor EF-Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (398 aa) |
| | ftsY | Putative cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC); Belongs to the GTP-binding SRP family. FtsY subfamily. (498 aa) |
| | lysS | lysyl-tRNA synthetase; Best Blastp Hit: sp|P37477|SYK_BACSU LYSYL-TRNA SYNTHETASE (LYSINE--TRNA LIGASE) (LYSRS) >gi|2127132|pir||S66111 lysine--tRNA ligase (EC 6.1.1.6) lysS - Bacillus subtilis >gi|467470|dbj|BAA05316.1| (D26185) lysyl-tRNA thynthetase [Bacillus subtilis] >gi|2632349|emb|CAB11858.1| (Z99104) lysyl-tRNA synthetase [Bacillus subtilis]; Belongs to the class-II aminoacyl-tRNA synthetase family. (496 aa) |
| | obg | Putative GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (436 aa) |
| | SMU_803c | Best Blastp Hit: dbj|BAB05744.1| (AP001514) ABC transporter (ATP-binding protein) [Bacillus halodurans]. (501 aa) |
| | SMU_804 | Hypothetical protein; Best Blastp Hit: pir||T28676 rhoptry protein - Plasmodium yoelii (fragment). (404 aa) |
| | uvrB | Excinuclease ABC (subunit B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociat [...] (663 aa) |
| | rpsU | Best Blastp Hit: pir||T43742 ribosomal protein S21 [imported] - Listeria monocytogenes >gi|5689043|dbj|BAA82793.1| (AB023064) 30S ribosomal protein S21 [Listeria monocytogenes]; Belongs to the bacterial ribosomal protein bS21 family. (58 aa) |
| | rpoD | DNA-dependent RNA polymerase sigma subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (371 aa) |
| | rplU | 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (104 aa) |
| | rpmA | Best Blastp Hit: sp|P05657|RL27_BACSU 50S RIBOSOMAL PROTEIN L27 (BL30) (BL24) >gi|80371|pir||C21895 ribosomal protein L27 - Bacillus subtilis >gi|40186|emb|CAA26492.1| (X02656) homologous to E.coli ribosomal protein L27 [Bacillus subtilis] >gi|2635259|emb|CAB14754.1| (Z99118) ribosomal protein L27 (BL24) [Bacillus subtilis]; Belongs to the bacterial ribosomal protein bL27 family. (97 aa) |
| | rpsP | 30S ribosomal protein S16; Best Blastp Hit: dbj|BAB06202.1| (AP001515) ribosomal protein S16 (BS17) [Bacillus halodurans]; Belongs to the bacterial ribosomal protein bS16 family. (91 aa) |
| | rimM | Putative 16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (172 aa) |
| | trmD | Putative tRNA methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (240 aa) |
| | ropA | Peptidyl-prolyl isomerase RopA (trigger factor); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (427 aa) |
| | rplJ | 50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (167 aa) |
| | rplL | 50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (122 aa) |
| | pyrG | CTP synthetase (UTP-ammonia lyase); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (536 aa) |
| | SMU_993 | Putative GTP-binding protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (283 aa) |
| | rnh | Putative ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (260 aa) |
