Your Input: | |
| | rlmN | Conserved hypothetical protein; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (361 aa) |
| | coaD | Putative phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (166 aa) |
| | hpf | Putative ribosome-associated protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (182 aa) |
| | SMU_494 | Putative transaldolase; Best Blastp Hit: emb|CAA05516.1| (AJ002527) OrfX [Clostridium beijerinckii]. (222 aa) |
| | sunL | Putative RNA-binding Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (437 aa) |
| | gpsB | Conserved hypothetical protein; Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation. (112 aa) |
| | nadE | NAD(+) synthetase (nitrogen-regulatory protein); Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (274 aa) |
| | recU | Putative recombination protein U; Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation; Belongs to the RecU family. (197 aa) |
| | kguA | Putative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (210 aa) |
| | trxB | Best Blastp Hit: dbj|BAB07290.1| (AP001519) thioredoxin reductase (NADPH) [Bacillus halodurans]. (304 aa) |
| | cshB | Putative ATP-dependent RNA helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures. (447 aa) |
| | rsmH | Conserved hypoyhetical protein; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (316 aa) |
| | proA | Putative gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (416 aa) |
| | proB | Putative gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (269 aa) |
| | SMU_447 | Best Blastp Hit: pir||E69894 hypothetical protein ynzC - Bacillus subtilis >gi|2634172|emb|CAB13672.1| (Z99113) ynzC [Bacillus subtilis]. (84 aa) |
| | sygB | Putative glycyl-tRNA synthetase (beta subunit); Best Blastp Hit: sp|P54381|SYGB_BACSU GLYCYL-TRNA SYNTHETASE BETA CHAIN (GLYCINE--TRNA LIGASE BETA CHAIN) (GLYRS) >gi|7437701|pir||B69636 glycine--tRNA ligase (EC 6.1.1.14) beta chain glyS - Bacillus subtilis >gi|1303829|dbj|BAA12485.1| (D84432) YqfK [Bacillus subtilis] >gi|2634958|emb|CAB14455.1| (Z99116) glycyl-tRNA synthetase (beta subunit) [Bacillus subtilis] >gi|2634972|emb|CAB14468.1| (Z99117) glycyl-tRNA synthetase (beta subunit) [Bacillus subtilis]. (679 aa) |
| | sygA | Best Blastp Hit: dbj|BAB05089.1| (AP001511) glycyl-tRNA synthetase (alpha subunit) [Bacillus halodurans]. (305 aa) |
| | rbfA | Ribosome binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (116 aa) |
| | infB | Translation initiation factor 2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily. (916 aa) |
| | nusA | Putative transcription factor NusA; Participates in both transcription termination and antitermination. (397 aa) |
| | rimP | Conserved hypothetical protein; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (163 aa) |
| | SMU_409 | Conserved hypothetical protein; Best Blastp Hit: dbj|BAB04264.1| (AP001508) unknown conserved protein [Bacillus halodurans]. (147 aa) |
| | dinB | Putative DNA-damage-inducible protein P; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (370 aa) |
| | pfl | Pyruvate formate-lyase; Best Blastp Hit: sp|Q59934|PFL_STRMU FORMATE ACETYLTRANSFERASE (PYRUVATE FORMATE-LYASE) >gi|1129082|dbj|BAA09085.1| (D50491) Pyruvate formate-lyase [Streptococcus mutans]. (775 aa) |
| | pepX | X-prolyl dipeptidyl peptidase; Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline; Belongs to the peptidase S15 family. (758 aa) |
| | SMU_394c | Conserved hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. (99 aa) |
| | tsaD | Putative glycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (336 aa) |
| | SMU_386 | Putative ribosomal-protein-alanine acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18. (144 aa) |
| | rnj-2 | Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (560 aa) |
| | pgk | Phosphoglycerate kinase; Best Blastp Hit: sp|Q9Z5C4|PGK_STAAU PHOSPHOGLYCERATE KINASE >gi|4490614|emb|CAB38646.1| (AJ133520) phosphoglycerate kinase [Staphylococcus aureus]; Belongs to the phosphoglycerate kinase family. (398 aa) |
| | fusA | Translation elongation factor G (EF-G); Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G [...] (693 aa) |
| | rsgA | Conserved hypothetical protein; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (290 aa) |
| | rsmA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (291 aa) |
| | rnmV | Conserved hypothetical protein; Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. (211 aa) |
| | purM | Best Blastp Hit: gb|AAC16901.1| (AF016634) phosphoribosylformylglycinamide cyclo-ligase [Lactococcus lactis subsp. cremoris]. (340 aa) |
| | SMU_338 | Putative RNA-binding protein, Jag family; Best Blastp Hit: pir||E72251 hypothetical protein TM1460 - Thermotoga maritima (strain MSB8) >gi|4982025|gb|AAD36528.1|AE001797_8 (AE001797) jag protein, putative [Thermotoga maritima]. (322 aa) |
| | argH | Argininosuccinate lyase; Best Blastp Hit: dbj|BAB06905.1| (AP001518) argininosuccinate lyase [Bacillus halodurans]. (460 aa) |
| | argG | Best Blastp Hit: dbj|BAB06906.1| (AP001518) argininosuccinate synthase (citrulline-asparate ligase) [Bacillus halodurans]; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (396 aa) |
| | gltX | Putative glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (485 aa) |
| | gpsA | Best Blastp Hit: sp|P46919|GPDA_BACSU GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(P)+] (NAD(P)H-DEPENDENT DIHYDROXYACETONE-PHOSPHATE REDUCTASE) >gi|974332|gb|AAA86746.1| (U32164) NAD(P)H-dependent dihydroxyacetone-phosphate reductase [Bacillus subtilis]; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa) |
| | SMU_313 | Putative PTS system, sorbitol-specific enzyme IIA; Best Blastp Hit: pir||T51726 phosphotransferase system enzyme II (EC 2.7.1.69) A, sorbitol-specific [imported] - Streptococcus mutans >gi|4928287|gb|AAD33523.1|AF132127_8 (AF132127) phosphotransferase enzyme IIA [Streptococcus mutans]. (121 aa) |
| | pgi | Glucose-6-phosphate isomerase; Best Blastp Hit: gb|AAD33517.1|AF132127_2 (AF132127) glucose-6-phosphate isomerase [Streptococcus mutans]. (449 aa) |
| | acpP | Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (82 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
| | otcA | Putative ornithine carbamoyltransferase; Catalyzes the phosphorolysis of N-carbamoylputrescine to form carbamoyl phosphate and putrescine (Probable). Is involved in the degradation pathway of the polyamine agmatine. Belongs to the aspartate/ornithine carbamoyltransferase superfamily. PTCase family. (339 aa) |
| | plsX | Putative fatty acid/phospholipid synthesis protein; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (332 aa) |
| | ilvH | Best Blastp Hit: sp|Q02140|ILVH_LACLA ACETOLACTATE SYNTHASE SMALL SUBUNIT (AHAS) (ACETOHYDROXY-ACID SYNTHASE SMALL SUBUNIT) (ALS) >gi|486731|pir||S35139 probable acetolactate synthase (EC 4.1.3.18) small chain - Lactococcus lactis subsp. lactis >gi|2565158|gb|AAB81920.1| (U92974) IlvN [Lactococcus lactis]. (160 aa) |
| | prs | Phosphoribosyl pyrophosphate synthetase (PRPP synthetase); Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (322 aa) |
| | rlmH | Conserved hypothetical protein; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (159 aa) |
| | trpS | Putative tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (340 aa) |
| | recF | Putative RecF protein, ATPase involved in DNA repair; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (363 aa) |
| | mnmA | Putative tRNA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (373 aa) |
| | gidA | Glucose inhibited division protein-like protein GidA; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (631 aa) |
| | hisS | Best Blastp Hit: sp|P30053|SYH_STREQ HISTIDYL-TRNA SYNTHETASE (HISTIDINE--TRNA LIGASE) (HISRS) >gi|11271795|pir||S30233 histidine--tRNA ligase (EC 6.1.1.21) [validated] - Streptococcus equisimilis. (429 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (589 aa) |
| | argS | Putative arginyl-tRNA synthase; Best Blastp Hit: gb|AAF86984.1|AF282249_3 (AF282249) ArgS [Lactococcus lactis subsp. lactis]. (563 aa) |
| | argR-2 | Hypothetical protein; Regulates arginine biosynthesis genes. (78 aa) |
| | argR | Putative transcriptional regulator of arginine metabolism; Regulates arginine biosynthesis genes. (145 aa) |
| | recA | Recombination protein RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (383 aa) |
| | SMU_2078c | Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family. (139 aa) |
| | hemZ | Putative ferrochelatase (protoheme ferro-lyase); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (319 aa) |
| | prmA | Putative methyltransferase; Methylates ribosomal protein L11; Belongs to the methyltransferase superfamily. PrmA family. (317 aa) |
| | SMU_2049c | Conserved hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (247 aa) |
| | dtd | Conserved hypothetical protein; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (148 aa) |
| | treA | Putative trehalose-6-phosphate hydrolase TreA; Best Blastp Hit: gb|AAB65079.1| (U35633) dextran glucosidase DexS [Streptococcus suis]. (542 aa) |
| | eftS | Putative translation elongation factor TS; Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. (348 aa) |
| | rplD | 50S ribosomal protein L4; Forms part of the polypeptide exit tunnel. (207 aa) |
| | rpsS | 30S ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (92 aa) |
| | rl18 | 50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (118 aa) |
| | adk | Putative adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa) |
| | if1 | Putative translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. (72 aa) |
| | rpoA | DNA-directed RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (312 aa) |
| | tyrS | Putative tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (422 aa) |
| | ackA | Putative acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa) |
| | proC | Putative pyrroline carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (256 aa) |
| | SMU_1960c | Putative PTS system, mannose-specific IIB component; Best Blastp Hit: gb|AAB04152.1| (U28163) phosphoenolpyruvate:mannose phosphotransferase element IIB [Lactobacillus curvatus]. (164 aa) |
| | groES | Putative co-chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (95 aa) |
| | groEL | Putative chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (542 aa) |
| | syl | Putative leucyl-tRNA synthetase; Best Blastp Hit: dbj|BAB07000.1| (AP001518) leucyl-tRNA synthetase [Bacillus halodurans]; Belongs to the class-I aminoacyl-tRNA synthetase family. (833 aa) |
| | gidB | Putative glucose-inhibited division protein; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (237 aa) |
| | hslO | Putative 33 kD chaperonin (heat shock protein 33) (HSP-33); Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress. (310 aa) |
| | sys | Putative seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | ptnA | Putative PTS system, mannose-specific component IIAB; Best Blastp Hit: gb|AAD46485.1|AF130465_1 (AF130465) mannose-specific phosphotransferase system component IIAB [Streptococcus salivarius]. (330 aa) |
| | rnh3 | Putative ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. RnhC subfamily. (303 aa) |
| | uvrA | Putative excinuclease ABC (subunit A); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa) |
| | efp | Putative translation elongation factor P; Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. (186 aa) |
| | scrB | Best Blastp Hit: sp|P13522|SCRB_STRMU SUCROSE-6-PHOSPHATE## HYDROLASE (SUCRASE) (INVERTASE) >gi|97999|pir||A43501 sucrose-6-phosphate hydrolase - Streptococcus mutans >gi|47259|emb|CAA35872.1| (X51507) sucrose-6-phosphate hydrolase [Streptococcus mutans] >gi|153804|gb|AAA26972.1| (M36849) sucrose-6-phosphate hydrolase [Streptococcus mutans]. (479 aa) |
| | secA | Preprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane; Belongs to the SecA family. (839 aa) |
| | acpS | Putative acyl carrier protein synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (119 aa) |
| | SMU_1828 | Conserved hypothetical protein; Best Blastp Hit: dbj|BAB06903.1| (AP001518) unknown conserved protein [Bacillus halodurans]. (149 aa) |
| | codY | Putative transcriptional regulator; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. (261 aa) |
| | gatA | Putative aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (583 aa) |
| | SMU_181 | Putative mevalonate kinase; Best Blastp Hit: gb|AAG02440.1|AF290093_1 (AF290093) mevalonate kinase [Enterococcus faecalis]. (332 aa) |
| | rsfS | Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (117 aa) |
| | tmcAL | Conserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac- AMP) and then transfers the acetyl group to tRNA to form ac(4)C34. (366 aa) |
| | SMU_1789c | Conserved hypothetical protein; Best Blastp Hit: sp|P76351|YEEN_ECOLI HYPOTHETICAL 25.9 KDA PROTEIN IN AMN-CBL INTERGENIC REGION >gi|7448338|pir||A64963 conserved hypothetical protein b1983 - Escherichia coli >gi|1788294|gb|AAC75047.1| (AE000290) orf, hypothetical protein [Escherichia coli]. (238 aa) |
| | proS | Putative prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and inv [...] (616 aa) |
| | recX | Conserved hypothetical protein; Modulates RecA activity; Belongs to the RecX family. (258 aa) |
| | syv | Putative valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (883 aa) |
| | fabH | Putative 3-oxoacyl-[acyl-carrier-protein] synthase III; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (325 aa) |
| | acp | Putative acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (74 aa) |
| | bccP | Putative biotin carboxyl carrier protein of acetyl-CoA carboxylase; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (153 aa) |
| | fabZ | Putative 3-hydroxymyristoyl-(acyl carrier protein) dehydratase; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (140 aa) |
| | accD | Putative acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa) |
| | accA | Putative acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (256 aa) |
| | murC | Putative UDP-N-acetyl muramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (452 aa) |
| | SMU_1724c | Putative rRNA methylase; Best Blastp Hit: dbj|BAB06831.1| (AP001517) rRNA methylase [Bacillus halodurans]; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (246 aa) |
| | SMU_1714c | Hypothetical protein; Putative tyrosine recombinase. Not involved in the cutting and rejoining of the recombining DNA molecules on dif(SL) site. Belongs to the 'phage' integrase family. XerD-like subfamily. (245 aa) |
| | scpA | Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. (235 aa) |
| | scpB | Conserved hypothetical protein; Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves. (198 aa) |
| | SMU_1707c | Putative rRNA methylase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily. (182 aa) |
| | pflA | Pyruvate-formate lyase activating enzyme; Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine; Belongs to the organic radical-activating enzymes family. (263 aa) |
| | dltA | Putative D-alanine-D-alanyl carrier protein ligase; Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. Belongs t [...] (516 aa) |
| | dltC | Putative D-alanyl carrier protein; Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC- carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. (79 aa) |
| | ppaC | Best Blastp Hit: sp|O68579|PPAC_STRMU PROBABLE MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE (PYROPHOSPHATE PHOSPHO-HYDROLASE) (PPASE) >gi|2952533|gb|AAC05778.1| (AF051356) putative exopolyphosphatase [Streptococcus mutans] >gi|3403205|gb|AAC29042.1| (AF050517) unknown [Streptococcus mutans]; Belongs to the PPase class C family. (310 aa) |
| | murE | Putative UDP-N-acetylmuramoylananine-D-glutamate-2,6- diaminopimelate ligase; Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (483 aa) |
| | clpP | Putative ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (196 aa) |
| | SMU_1670c | Best Blastp Hit: pir||D69874 conserved hypothetical protein ylbG - Bacillus subtilis >gi|2340003|emb|CAB11353.1| (Z98682) YlbG protein [Bacillus subtilis] >gi|2633871|emb|CAB13373.1| (Z99111) similar to hypothetical proteins [Bacillus subtilis]. (82 aa) |
| | rsmI | Conserved hypothetical protein; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (288 aa) |
| | serC | Putative phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (363 aa) |
| | ogt | Putative methylated-DNA--protein-cysteine S-methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (164 aa) |
| | SMU_1645 | Best Blastp Hit: sp|P45134|TEHB_HAEIN TELLURITE RESISTANCE PROTEIN TEHB HOMOLOG >gi|1075338|pir||H64113 hemagglutinin hag1 homolog - Haemophilus influenzae (strain Rd KW20) >gi|1574730|gb|AAC22923.1| (U32807) tellurite resistance protein (tehB) [Haemophilus influenzae Rd]. (293 aa) |
| | SMU_164 | Putative tRNA/rRNA methyltransferase; Best Blastp Hit: sp|Q06753|YACO_BACSU HYPOTHETICAL TRNA/RRNA METHYLTRANSFERASE YACO >gi|2127060|pir||S66124 conserved hypothetical protein yacO - Bacillus subtilis >gi|467483|dbj|BAA05329.1| (D26185) unknown [Bacillus subtilis] >gi|2632363|emb|CAB11872.1| (Z99104) similar to hypothetical proteins [Bacillus subtilis]; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (248 aa) |
| | metS | Putative methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily. (669 aa) |
| | glmU | Putative UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. (459 aa) |
| | pyrH | Putative uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (245 aa) |
| | rrf1 | Putative ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family. (185 aa) |
| | ybeY | Conserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (164 aa) |
| | era | GTP-binding protein; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity). Has GTPase activity, binds both GDP and GTP, does not bind UTP, CTP or ATP. (299 aa) |
| | coaE | Conserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa) |
| | rl33 | Best Blastp Hit: sp|P23375|RL33_BACST 50S RIBOSOMAL PROTEIN L33 >gi|477793|pir||B48396 ribosomal protein L33 - Bacillus stearothermophilus >gi|240272|gb|AAB20569.1| BstL33=50S ribosomal subunit protein [Bacillus stearothermophilus, Peptide, 49 aa] >gi|243175|gb|AAB21086.1| ribosomal protein L33 [Bacillus stearothermophilus, Peptide, 49 aa] >gi|228174|prf||1718186B ribosomal protein L33 [Bacillus stearothermophilus]; Belongs to the bacterial ribosomal protein bL33 family. (48 aa) |
| | vacB | Putative exoribonuclease R (RNAase R); 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (778 aa) |
| | smpB | Putative SsrA-binding protein-like protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The rib [...] (155 aa) |
| | mrnC | Conserved hypothetical protein; Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc); Rnc processes 30S rRNA into smaller rRNA precursors; Belongs to the MrnC RNase family. (139 aa) |
| | syt1 | Putative threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr). (649 aa) |
| | cysS | Best Blastp Hit: sp|Q06752|SYC_BACSU CYSTEINYL-TRNA SYNTHETASE (CYSTEINE--TRNA LIGASE) (CYSRS) >gi|541406|pir||C53402 cysteine--tRNA ligase (EC 6.1.1.16) cysS - Bacillus subtilis >gi|289284|gb|AAA21798.1| (L14580) cysteinyl-tRNA synthetase [Bacillus subtilis] >gi|467482|dbj|BAA05328.1| (D26185) cysteinyl-tRNA synthetase [Bacillus subtilis] >gi|499303|emb|CAA52167.1| (X73989) cysteine--tRNA ligase [Bacillus subtilis] >gi|2632361|emb|CAB11870.1| (Z99104) cysteinyl-tRNA synthetase [Bacillus subtilis]; Belongs to the class-I aminoacyl-tRNA synthetase family. (447 aa) |
| | metK | Putative S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (397 aa) |
| | murZ | Putative UDP-N-acetylglucosamine-1-carboxyvinyl transferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa) |
| | cysE | Putative serine acetyltransferase; Best Blastp Hit: gb|AAC33374.1| (AF001780) NifP [Cyanothece PCC8801]. (222 aa) |
| | pnpA | Polyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (730 aa) |
| | rpsO | 30S ribosomal protein S15; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA. (89 aa) |
| | murA | Putative UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (423 aa) |
| | rnc | Putative ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity). Belongs to the ribonuclease III family. (231 aa) |
| | smc | Putative chromosome segregation ATPase; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1178 aa) |
| | syfA | Putative phenylalanyl-tRNA synthetase (alpha subunit); Best Blastp Hit: sp|P17921|SYFA_BACSU PHENYLALANYL-TRNA SYNTHETASE ALPHA CHAIN (PHENYLALANINE--TRNA LIGASE ALPHA CHAIN) (PHERS) >gi|7428485|pir||YFBSA phenylalanine--tRNA ligase (EC 6.1.1.20) alpha chain - Bacillus subtilis >gi|1770030|emb|CAA99603.1| (Z75208) phenylalany-tRNA synthetase beta subunit [Bacillus subtilis] >gi|2635329|emb|CAB14824.1| (Z99118) phenylalanyl-tRNA synthetase (alpha subunit) [Bacillus subtilis]; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (347 aa) |
| | syfB | Putative phenylalanyl-tRNA synthetase (beta subunit); Best Blastp Hit: sp|P17922|SYFB_BACSU PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN (PHENYLALANINE--TRNA LIGASE BETA CHAIN) (PHERS) >gi|7428487|pir||YFBSB phenylalanine--tRNA ligase (EC 6.1.1.20) beta chain - Bacillus subtilis >gi|1770031|emb|CAA99564.1| (Z75208) phenylalanyl-tRNA synthetase beta subunit [Bacillus subtilis] >gi|2635328|emb|CAB14823.1| (Z99118) phenylalanyl-tRNA synthetase (beta subunit) [Bacillus subtilis]. (801 aa) |
| | lacF | PTS system, lactose-specific enzyme IIA EIIA-LAC); The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II LacEF PTS system is involved in lactose transport. (104 aa) |
| | hflX | Putative GTP-binding protein; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (415 aa) |
| | apt | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa) |
| | metA | Putative homoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (314 aa) |
| | rnj | Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (554 aa) |
| | clpB | Putative Clp proteinase, ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to th [...] (860 aa) |
| | hemN | Putative coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (380 aa) |
| | hprT | Best Blastp Hit: sp|Q02522|HPRT_LACLA HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) (HGPRTASE) >gi|418760|pir||S30100 hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) - Lactococcus lactis >gi|44026|emb|CAA48876.1| (X69123) hypoxanthine guanine phosphoribosyltransferase [Lactococcus lactis] >gi|49105|emb|CAA47404.1| (X67015) hypoxanthine phosphoribosyltransferase [Lactococcus lactis] >gi|384297|prf||1905381A hypoxanthine guanine phosphoribosyltransferase [Lactococcus lactis]. (180 aa) |
| | urk | Putative uridine kinase; Best Blastp Hit: sp|O32033|URK_BACSU URIDINE KINASE (URIDINE MONOPHOSPHOKINASE) >gi|7449167|pir||G69728 uridine kinase udk - Bacillus subtilis >gi|2635179|emb|CAB14675.1| (Z99117) uridine kinase [Bacillus subtilis]. (209 aa) |
| | leuB | Putative 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (344 aa) |
| | leuD | Putative 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (196 aa) |
| | SMU_1327c | Best Blastp Hit: pir||E69820 conserved hypothetical protein yhbA - Bacillus subtilis >gi|1903044|emb|CAB07527.1| (Z93102) hypothetical 48.5 kd protein [Bacillus subtilis] >gi|2633214|emb|CAB12719.1| (Z99108) alternate gene name: ygaP similar to hypothetical proteins [Bacillus subtilis]. (373 aa) |
| | rf2 | Putative peptide chain release factor (RF-2); Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. (325 aa) |
| | asnS | Best Blastp Hit: sp|P39772|SYN_BACSU ASPARAGINYL-TRNA SYNTHETASE (ASPARAGINE--TRNA LIGASE) (ASNRS) >gi|7437578|pir||B69591 asparagine--tRNA ligase (EC 6.1.1.22) asnS - Bacillus subtilis >gi|1146247|gb|AAB38455.1| (L47709) asparaginyl-tRNA synthetase [Bacillus subtilis] >gi|2634654|emb|CAB14152.1| (Z99115) asparaginyl-tRNA synthetase [Bacillus subtilis]. (448 aa) |
| | SMU_1305c | Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (325 aa) |
| | tilS | Putative cell-cycle protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (423 aa) |
| | gyrB | Putative DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (650 aa) |
| | ezrA | Putative septation ring formation regulator; Negative regulator of FtsZ ring formation; modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization; Belongs to the EzrA family. (574 aa) |
| | hisZ | Putative histidyl-tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (320 aa) |
| | hisG | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (215 aa) |
| | hisB | Best Blastp Hit: dbj|BAB07300.1| (AP001519) imidazoleglycerol-phosphate dehydratase [Bacillus halodurans]. (194 aa) |
| | hisH | Putative glutamine amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (201 aa) |
| | hisA | Best Blastp Hit: gb|AAF05093.1|AF150930_2 (AF150930) phosphoribosyl formimino-5-aminoimidazole isomerase [Thermoanaerobacter ethanolicus]. (239 aa) |
| | hisF | Putative imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa) |
| | hisI | Putative phosphoribosyl-ATP pyrophosphatase / phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (109 aa) |
| | eno | Putative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen and human salivary mucin MG2 when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity that may help the dissemination through oral tissues and entrance into the blood stream; Belongs to the enolase family. (432 aa) |
| | uvrC | Putative excinuclease ABC (subunit C); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (595 aa) |
| | thdF | Putative thiophene and furan degradation protein; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (455 aa) |
| | deoB | Putative phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (403 aa) |
| | polC | DNA polymerase III, alpha subunit; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1465 aa) |
| | pyrDB | Putative dihydroorotate dehydrogenase B; Catalyzes the conversion of dihydroorotate to orotate. (309 aa) |
| | ung | Putative uracil DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (217 aa) |
| | dnaE | DNA polymerase III, alpha chain; Best Blastp Hit: gb|AAF98350.1| (AF280766) DNA polymerase III alpha subunit [Streptococcus pyogenes]. (1034 aa) |
| | pfk | 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (337 aa) |
| | glmS | Glucosamine-fructose-6-phosphate aminotransferase; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. (604 aa) |
| | mtlA2 | PTS system, mannitol-specific enzyme IIA; The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II CmtAB PTS system is involved in D-mannitol transport. (145 aa) |
| | pcrA | ATP-dependent DNA helicase; Best Blastp Hit: sp|O34580|PCRA_BACSU ATP-DEPENDENT DNA HELICASE PCRA >gi|7436413|pir||E69794 ATP-dependent DNA helicase homolog yerF - Bacillus subtilis >gi|2577965|emb|CAA75552.1| (Y15254) PcrA protein [Bacillus subtilis] >gi|2632975|emb|CAB12481.1| (Z99107) similar to ATP-dependent DNA helicase [Bacillus subtilis]. (733 aa) |
| | spxA | Putative arsenate reductase; Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development- promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress. Belongs to the ArsC family. Spx subfamily. (137 aa) |
| | phoU | Putative phosphate transport system regulatory protein; Plays a role in the regulation of phosphate uptake. (217 aa) |
| | coaA | Putative pantothenate kinase; Best Blastp Hit: dbj|BAB06594.1| (AP001516) pantothenate kinase [Bacillus halodurans]. (306 aa) |
| | deoC | Putative deoxyribose-phosphate aldolase; Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5- phosphate; Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. (220 aa) |
| | ldh | Lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (328 aa) |
| | gyrA | DNA gyrase A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (825 aa) |
| | kitH | Putative thymidine kinase; Best Blastp Hit: sp|P47848|KITH_STRGC THYMIDINE KINASE >gi|703442|gb|AAB02289.1| (L40415) thymidine kinase [Streptococcus gordonii]. (194 aa) |
| | rf1 | Putative peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. (359 aa) |
| | glyA | Putative serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (420 aa) |
| | ffh | Signal recognition particle protein subunit, Ffh; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. (516 aa) |
| | rex | Conserved hypothetical protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. (213 aa) |
| | krpS | Putative phosphoribosylpyrophosphate synthetase, PRPP synthetase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa) |
| | nadK | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (277 aa) |
| | xerS | Putative integrase/recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. Essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. (356 aa) |
| | cilA | Putative citrate lyase, alfa subunit; Best Blastp Hit: pir||T46731 citrate (pro-3S)-lyase (EC 4.1.3.6) alpha chain [imported] - Weissella paramesenteroides plasmid >gi|6249494|emb|CAB60043.1| (AJ132782) putative alfa subunit of citrate lyase [Weissella paramesenteroides]. (511 aa) |
| | cilB | Best Blastp Hit: sp|O53078|CILB_LEUMC CITRATE LYASE BETA CHAIN (CITRASE) (CITRYL-COA LYASE SUBUNIT) >gi|2842396|emb|CAA71632.1| (Y10621) CILB, citryl-CoA lyase beta subunit [Leuconostoc mesenteroides]; Belongs to the HpcH/HpaI aldolase family. (300 aa) |
| | cilG | Putative citrate lyase, gamma-subunit; Covalent carrier of the coenzyme of citrate lyase. (102 aa) |
| | gid | Putative glucose-inhibited division protein; Catalyzes the folate-dependent formation of 5-methyl-uridine at position 54 (M-5-U54) in all tRNAs; Belongs to the MnmG family. TrmFO subfamily. (444 aa) |
| | SMU_100 | Best Blastp Hit: gb|AAF24132.1|AF129168_5 (AF129168) EIIB sorbose-PTS homolog [Lactobacillus casei]. (163 aa) |
| | trcF | Putative transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1162 aa) |
| | pth | Putative peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (189 aa) |
| | dnaN | Putative DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for init [...] (378 aa) |
| | dnaA | Chromosomal replication initiator protein, DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. (452 aa) |
| | ptsH | Phosphoenolpyruvate:sugar phosphotransferase system HPr; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. (87 aa) |
| | citZ | Citrate synthase; Best Blastp Hit: sp|Q59939|CISZ_STRMU CITRATE SYNTHASE >gi|1421813|gb|AAC44825.1| (U62799) citrate synthase [Streptococcus mutans]. (372 aa) |
| | nrdG | Putative ribonucleotide reductase, small subunit; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (319 aa) |
| | argD | Best Blastp Hit: dbj|BAB06616.1| (AP001517) N-acetylornithine aminotransferase [Bacillus halodurans]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (379 aa) |
| | argB | Putative acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (245 aa) |
| | argJ | Putative ornithine acetyltransferase/N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (397 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (340 aa) |
| | alaS | Putative alanyl-tRNA synthetase (alanine--tRNA ligase); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (872 aa) |
| | queA | Putative S-adenosylmethionine--tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (342 aa) |
| | SMU_633 | Putative thioesterase; Best Blastp Hit: gb|AAF97985.1| (AY005822) peroxisomal long-chain acyl-coA thioesterase [Homo sapiens]. (409 aa) |
| | cshA | Putative ATP-dependent RNA helicase, DEAD-box family; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily. (517 aa) |
| | prfC | Putative translation elongation and release factor; Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (514 aa) |
| | murF | Putative D-Ala-D-Ala adding enzyme; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa) |
| | ddl | Putative D-alanine-D-alanine ligase; Cell wall formation. (349 aa) |
| | pyrD | Putative dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (311 aa) |
| | argR-3 | Putative arginine repressor; Regulates arginine biosynthesis genes. (154 aa) |
| | xseB | Putative exodeoxyribonuclease VII, small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (73 aa) |
| | glk | Putative glucose kinase; Best Blastp Hit: pir||T44787 glucokinase (EC 2.7.1.2) [imported] - Bacillus megaterium >gi|2274867|emb|CAA03848.1| (AJ000005) glucose kinase [Bacillus megaterium]. (323 aa) |
| | xseA | Putative exodeoxyribonuclease VII, large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (447 aa) |
| | lytR | Putative response regulator LytR; Member of the two-component regulatory system LytR/LytS that probably regulates genes involved in cell wall metabolism. (244 aa) |
| | argF | Putative ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family. (326 aa) |
| | ileS | isoleucine-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (930 aa) |
| | divIVA | Best Blastp Hit: gb|AAC95445.1| (AF068901) cell division protein DivIVA [Streptococcus pneumoniae]. (271 aa) |
| | ylmF | Conserved hypothetical protein; Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA. (191 aa) |
| | ftsZ | Putative cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (434 aa) |
| | murD | Putative D-glutamic acid adding enzyme MurD; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (451 aa) |
| | SMU_546 | Putative GTP-binding protein; Best Blastp Hit: dbj|BAB06351.1| (AP001516) GTP-binding protein TypA/BipA (tyrosine phosphorylated protein A) [Bacillus halodurans]. (614 aa) |
| | rnh | Putative ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (260 aa) |
| | SMU_993 | Putative GTP-binding protein; Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (283 aa) |
| | dapA | Putative dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa) |
| | murB | Putative UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (306 aa) |
| | folC | Putative folyl-polyglutamate synthetase; Best Blastp Hit: sp|Q05865|FOLC_BACSU FOLYLPOLYGLUTAMATE SYNTHASE (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) >gi|421496|pir||B40646 folyl-polyglutamate synthetase folC - Bacillus subtilis >gi|142936|gb|AAB59021.1| (L04520) folyl-polyglutamate synthetase [Bacillus subtilis] >gi|2635273|emb|CAB14768.1| (Z99118) folyl-polyglutamate synthetase [Bacillus subtilis]. (425 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (288 aa) |
| | thyA | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (279 aa) |
| | fni | Putative dehydrogenase (FMN-dependent family protein); Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). (331 aa) |
| | SMU_937 | Best Blastp Hit: gb|AAG02456.1|AF290099_2 (AF290099) mevalonate diphosphate decarboxylase [Streptococcus pneumoniae]. (310 aa) |
| | queF | Conserved hypothetical protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (162 aa) |
| | ropA | Peptidyl-prolyl isomerase RopA (trigger factor); Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (427 aa) |
| | dapB | Putative dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate. (255 aa) |
| | galT | galactose-1-P-uridyl transferase, GalT; Best Blastp Hit: sp|P96994|GAL7_STRMU GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE (GAL-1-P URIDYLYLTRANSFERASE) >gi|7448853|pir||JC5312 UTP--hexose-1-phosphate uridylyltransferase (EC 2.7.7.10) - Streptococcus mutans >gi|1877423|gb|AAB49737.1| (U21942) galactose-1-P-uridyl transferase [Streptococcus mutans]. (491 aa) |
| | galK | Galactokinase, GalK; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (390 aa) |
| | dexB | Dextran glucosidase DexB; The physiological substrates may be short isomaltosaccharides. (536 aa) |
| | gtfA | Sucrose phosphorylase, GtfA; Intracellular catabolism of sucrose. Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris. (481 aa) |
| | trmD | Putative tRNA methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (240 aa) |
| | rimM | Putative 16S rRNA processing protein; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (172 aa) |
| | SMU_866 | Conserved hypothetical protein; Best Blastp Hit: sp|O31738|YLQC_BACSU HYPOTHETICAL 9.1 KDA PROTEIN IN RPSP-TRMD INTERGENIC REGION >gi|7430170|pir||C69880 conserved hypothetical protein ylqC - Bacillus subtilis >gi|2633972|emb|CAB13473.1| (Z99112) similar to hypothetical proteins [Bacillus subtilis]; Belongs to the UPF0109 family. (79 aa) |
| | rpsP | 30S ribosomal protein S16; Best Blastp Hit: dbj|BAB06202.1| (AP001515) ribosomal protein S16 (BS17) [Bacillus halodurans]; Belongs to the bacterial ribosomal protein bS16 family. (91 aa) |
| | rplU | 50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (104 aa) |
| | thiI | Putative thiamine biosynthesis protein; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (405 aa) |
| | fol | Putative folyl-polyglutamate synthetase; Best Blastp Hit: sp|Q05865|FOLC_BACSU FOLYLPOLYGLUTAMATE SYNTHASE (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) >gi|421496|pir||B40646 folyl-polyglutamate synthetase folC - Bacillus subtilis >gi|142936|gb|AAB59021.1| (L04520) folyl-polyglutamate synthetase [Bacillus subtilis] >gi|2635273|emb|CAB14768.1| (Z99118) folyl-polyglutamate synthetase [Bacillus subtilis]. (418 aa) |
| | dnaJ | Heat shock protein DnaJ (HSP-40); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] (377 aa) |
| | rpoD | DNA-dependent RNA polymerase sigma subunit; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (371 aa) |
| | grpE | Heat shock protein GrpE (HSP-70 cofactor); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Seve [...] (179 aa) |
| | uvrB | Excinuclease ABC (subunit B); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociat [...] (663 aa) |
| | obg | Putative GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (436 aa) |
| | aroK | Putative shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (158 aa) |
| | aroA | 5-enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (427 aa) |
| | aroB | Putative 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family. (355 aa) |
| | lysS | lysyl-tRNA synthetase; Best Blastp Hit: sp|P37477|SYK_BACSU LYSYL-TRNA SYNTHETASE (LYSINE--TRNA LIGASE) (LYSRS) >gi|2127132|pir||S66111 lysine--tRNA ligase (EC 6.1.1.6) lysS - Bacillus subtilis >gi|467470|dbj|BAA05316.1| (D26185) lysyl-tRNA thynthetase [Bacillus subtilis] >gi|2632349|emb|CAB11858.1| (Z99104) lysyl-tRNA synthetase [Bacillus subtilis]; Belongs to the class-II aminoacyl-tRNA synthetase family. (496 aa) |
| | ahpC | Alkyl hydroperoxide reductase; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily. (186 aa) |
| | SMU_752 | Conserved hypothetical protein; Best Blastp Hit: dbj|BAA90855.1| (AB031213) YdcK [Bacillus halodurans] >gi|10173145|dbj|BAB04251.1| (AP001508) unknown conserved protein in B. subtilis [Bacillus halodurans]; Belongs to the SprT family. (145 aa) |
| | ftsY | Putative cell division protein FtsY; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC); Belongs to the GTP-binding SRP family. FtsY subfamily. (498 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa) |
| | tuf | Translation elongation factor EF-Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (398 aa) |
| | infC | Putative translation initiation factor IF3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. (176 aa) |
| | cmk | Putative cytidylate kinase; Best Blastp Hit: sp|P38493|KCY_BACSU CYTIDYLATE KINASE (CK) (CYTIDINE MONOPHOSPHATE KINASE) (CMP KINASE) >gi|7448348|pir||F69601 cytidylate kinase cmk - Bacillus subtilis >gi|533105|gb|AAA85149.1| (U11687) unknown [Bacillus subtilis] >gi|1146214|gb|AAC83961.1| (L47648) cytidine monophosphate kinase [Bacillus subtilis] >gi|2634707|emb|CAB14205.1| (Z99115) cytidylate kinase [Bacillus subtilis] >gi|2634724|emb|CAB14221.1| (Z99116) cytidylate kinase [Bacillus subtilis]. (227 aa) |
| | pepT | Putative tripeptidase (peptidase T); Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. (406 aa) |
| | ptsI | Phosphoenolpyruvate:sugar phosphotransferase system enzyme I, PTS system EI component; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (577 aa) |
