STRINGSTRING
atpC atpC atpB atpB atpA atpA apt apt dacA-2 dacA-2 hprT hprT eno eno SMU_1206c SMU_1206c pfk pfk pykF pykF coaA coaA ldh ldh dfp dfp SMU_1074 SMU_1074 guaA guaA SMU_1046c SMU_1046c cilA cilA cilB cilB fbaA fbaA SMU_943c SMU_943c mvaA mvaA SMU_937 SMU_937 SMU_926 SMU_926 tpiA tpiA SMU_633 SMU_633 pmgY pmgY purB purB glk glk coaD coaD purK purK purE purE purD purD kguA kguA purH purH pgk pgk purN purN purM purM purF purF pgi pgi purC purC purA purA guaB guaB relA relA adk adk ackA ackA accC accC accD accD accA accA coaE coaE atpH atpH atpG atpG atpF atpF atpE atpE atpD atpD
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
atpCFoF1 membrane-bound proton-translocating ATPase, gamma subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (292 aa)
atpBFoF1 membrane-bound proton-translocating ATPase, beta subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits; Belongs to the ATPase alpha/beta chains family. (468 aa)
atpAFoF1 membrane-bound proton-translocating ATPase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (138 aa)
aptPutative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (172 aa)
dacA-2Conserved hypothetical protein; Catalyzes the condensation of 2 ATP molecules into cyclic di- AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria; Belongs to the adenylate cyclase family. DacA/CdaA subfamily. (284 aa)
hprTBest Blastp Hit: sp|Q02522|HPRT_LACLA HYPOXANTHINE-GUANINE PHOSPHORIBOSYLTRANSFERASE (HGPRT) (HGPRTASE) >gi|418760|pir||S30100 hypoxanthine phosphoribosyltransferase (EC 2.4.2.8) - Lactococcus lactis >gi|44026|emb|CAA48876.1| (X69123) hypoxanthine guanine phosphoribosyltransferase [Lactococcus lactis] >gi|49105|emb|CAA47404.1| (X67015) hypoxanthine phosphoribosyltransferase [Lactococcus lactis] >gi|384297|prf||1905381A hypoxanthine guanine phosphoribosyltransferase [Lactococcus lactis]. (180 aa)
enoPutative enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen and human salivary mucin MG2 when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity that may help the dissemination through oral tissues and entrance into the blood stream; Belongs to the enolase family. (432 aa)
SMU_1206cHypothetical protein; Best Blastp Hit: dbj|BAB02036.1| (AB022219) contains similarity to (p)ppGpp synthase (GTP pyrophosphokinase) gene_id:MKP6.2 [Arabidopsis thaliana]. (185 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (337 aa)
pykFPyruvate kinase; Best Blastp Hit: gb|AAF25804.1|AF172173_2 (AF172173) pyruvate kinase [Streptococcus thermophilus]. (500 aa)
coaAPutative pantothenate kinase; Best Blastp Hit: dbj|BAB06594.1| (AP001516) pantothenate kinase [Bacillus halodurans]. (306 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (328 aa)
dfpPutative DNA/pantothenate metabolism flavoprotein; Catalyzes the decarboxylation of 4'- phosphopantothenoylcysteine to 4'-phosphopantetheine; Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily. (179 aa)
SMU_1074Best Blastp Hit: pir||D69029 pantothenate metabolism flavoprotein dfp homolog MTH1216 - Methanobacterium thermoautotrophicum (strain Delta H) >gi|2622326|gb|AAB85705.1| (AE000889) pantothenate metabolism flavoprotein [Methanobacterium thermoautotrophicum]. (228 aa)
guaAPutative GMP synthase; Catalyzes the synthesis of GMP from XMP. (517 aa)
SMU_1046cPutative GTP pyrophosphokinase; Best Blastp Hit: dbj|BAB06568.1| (AP001516) GTP pyrophosphokinase [Bacillus halodurans]. (221 aa)
cilAPutative citrate lyase, alfa subunit; Best Blastp Hit: pir||T46731 citrate (pro-3S)-lyase (EC 4.1.3.6) alpha chain [imported] - Weissella paramesenteroides plasmid >gi|6249494|emb|CAB60043.1| (AJ132782) putative alfa subunit of citrate lyase [Weissella paramesenteroides]. (511 aa)
cilBBest Blastp Hit: sp|O53078|CILB_LEUMC CITRATE LYASE BETA CHAIN (CITRASE) (CITRYL-COA LYASE SUBUNIT) >gi|2842396|emb|CAA71632.1| (Y10621) CILB, citryl-CoA lyase beta subunit [Leuconostoc mesenteroides]; Belongs to the HpcH/HpaI aldolase family. (300 aa)
fbaABest Blastp Hit: dbj|BAB16889.1| (AB050113) class-II aldolase [Streptococcus bovis]. (293 aa)
SMU_943cPutative hydroxymethylglutaryl-CoA synthase; Best Blastp Hit: gb|AAG02453.1|AF290098_1 (AF290098)## HMG-CoA synthase [Streptococcus pneumoniae]. (391 aa)
mvaAPutative hydroxymethylglutaryl-CoA reductase; Best Blastp Hit: gb|AAG02449.1|AF290096_2 (AF290096) HMG-CoA reductase [Streptococcus pyogenes]. (427 aa)
SMU_937Best Blastp Hit: gb|AAG02456.1|AF290099_2 (AF290099) mevalonate diphosphate decarboxylase [Streptococcus pneumoniae]. (310 aa)
SMU_926Conserved hypothetical protein; Best Blastp Hit: dbj|BAB05604.1| (AP001513) unknown conserved protein [Bacillus halodurans]. (207 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (252 aa)
SMU_633Putative thioesterase; Best Blastp Hit: gb|AAF97985.1| (AY005822) peroxisomal long-chain acyl-coA thioesterase [Homo sapiens]. (409 aa)
pmgYPhosphoglyceromutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (230 aa)
purBAdenylosuccinate lyase; Best Blastp Hit: dbj|BAB04344.1| (AP001509) adenylosuccinate lyase [Bacillus halodurans]. (432 aa)
glkPutative glucose kinase; Best Blastp Hit: pir||T44787 glucokinase (EC 2.7.1.2) [imported] - Bacillus megaterium >gi|2274867|emb|CAA03848.1| (AJ000005) glucose kinase [Bacillus megaterium]. (323 aa)
coaDPutative phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (166 aa)
purKPutative phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (363 aa)
purEPutative phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (162 aa)
purDPutative phosphoribosylamine-glycine ligase; Best Blastp Hit: sp|Q9ZF44|PUR2_LACLA PHOSPHORIBOSYLAMINE--GLYCINE LIGASE (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNTHETASE) >gi|3892883|emb|CAA04374.1| (AJ000883) purD [Lactococcus lactis]. (419 aa)
kguAPutative guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (210 aa)
purHBest Blastp Hit: dbj|BAB04352.1| (AP001509) phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Bacillus halodurans]. (520 aa)
pgkPhosphoglycerate kinase; Best Blastp Hit: sp|Q9Z5C4|PGK_STAAU PHOSPHOGLYCERATE KINASE >gi|4490614|emb|CAB38646.1| (AJ133520) phosphoglycerate kinase [Staphylococcus aureus]; Belongs to the phosphoglycerate kinase family. (398 aa)
purNPutative phosphoribosylglycinamide formyltransferase (GART); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (184 aa)
purMBest Blastp Hit: gb|AAC16901.1| (AF016634) phosphoribosylformylglycinamide cyclo-ligase [Lactococcus lactis subsp. cremoris]. (340 aa)
purFPhosphoribosylpyrophosphate amidotransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. (479 aa)
pgiGlucose-6-phosphate isomerase; Best Blastp Hit: gb|AAD33517.1|AF132127_2 (AF132127) glucose-6-phosphate isomerase [Streptococcus mutans]. (449 aa)
purCBest Blastp Hit: sp|Q07296|PUR7_STRPN PHOSPHORIBOSYLAMINOIMIDAZOLE-SUCCINOCARBOXAMIDE SYNTHASE (SAICAR SYNTHETASE) >gi|625868|pir||A36941 phosphoribosylaminoimidazolesuccinocarboxamide synthase (EC 6.3.2.6) - Streptococcus pneumoniae >gi|295192|gb|AAA03540.1| (L15190) SAICAR synthetase [Streptococcus pneumoniae] >gi|663281|gb|AAA69512.1| (M36180) SAICAR synthetase [Streptococcus pneumoniae]. (235 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
guaBInosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (493 aa)
relAPutative stringent response protein, ppGpp synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (740 aa)
adkPutative adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (212 aa)
ackAPutative acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (399 aa)
accCPutative acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (456 aa)
accDPutative acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
accAPutative acetyl-CoA carboxylase alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (256 aa)
coaEConserved hypothetical protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (198 aa)
atpHFoF1 membrane-bound proton-translocating ATPase, c subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (67 aa)
atpGFoF1 membrane-bound proton-translocating ATPase, a subunit; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. (239 aa)
atpFFoF1 membrane-bound proton-translocating ATPase, b subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (165 aa)
atpEFoF1 membrane-bound proton-translocating ATPase, delta subunit; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation; Belongs to the ATPase delta chain family. (178 aa)
atpDFoF1 membrane-bound proton-translocating ATPase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family. (501 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
Server load: medium (46%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.