STRINGSTRING
scrK scrK treA treA scrB scrB rpiB rpiB SMU_229 SMU_229 glk glk idh idh pfkB pfkB gtfA gtfA galK galK gtfD gtfD gtfB gtfB gtfC gtfC fruP fruP SMU_1140c SMU_1140c lacD2 lacD2 mtlD mtlD pfk pfk rmlB rmlB rmlA rmlA lacG lacG lacD lacD lacC lacC lacB lacB lacA lacA lacR lacR glgA glgA glgD glgD glgC glgC glgB glgB
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
scrKPutative fructokinase; Best Blastp Hit: sp|Q07211|SCRK_STRMU FRUCTOKINASE >gi|287459|dbj|BAA02467.1| (D13175) fructokinase [Streptococcus mutans]. (293 aa)
treAPutative trehalose-6-phosphate hydrolase TreA; Best Blastp Hit: gb|AAB65079.1| (U35633) dextran glucosidase DexS [Streptococcus suis]. (542 aa)
scrBBest Blastp Hit: sp|P13522|SCRB_STRMU SUCROSE-6-PHOSPHATE## HYDROLASE (SUCRASE) (INVERTASE) >gi|97999|pir||A43501 sucrose-6-phosphate hydrolase - Streptococcus mutans >gi|47259|emb|CAA35872.1| (X51507) sucrose-6-phosphate hydrolase [Streptococcus mutans] >gi|153804|gb|AAA26972.1| (M36849) sucrose-6-phosphate hydrolase [Streptococcus mutans]. (479 aa)
rpiBPutative sugar-phosphate isomerase; Best Blastp Hit: sp|P23495|LACB_LACLA GALACTOSE-6-PHOSPHATE ISOMERASE LACB SUBUNIT >gi|97930|pir||B39778 galactose-6-phosphate isomerase (EC 5.3.1.-) component LacB - Lactococcus lactis >gi|149394|gb|AAA25169.1| (M65190) lacB [Lactococcus lactis] >gi|149407|gb|AAA25178.1| (M60447) galactose 6-P isomerase [Lactococcus lactis]. (210 aa)
SMU_229Best Blastp Hit: pir||E69879 conserved hypothetical protein yloV - Bacillus subtilis >gi|2337813|emb|CAA74257.1| (Y13937) YloV protein [Bacillus subtilis] >gi|2633956|emb|CAB13457.1| (Z99112) similar to hypothetical proteins [Bacillus subtilis]. (555 aa)
glkPutative glucose kinase; Best Blastp Hit: pir||T44787 glucokinase (EC 2.7.1.2) [imported] - Bacillus megaterium >gi|2274867|emb|CAA03848.1| (AJ000005) glucose kinase [Bacillus megaterium]. (323 aa)
idhBest Blastp Hit: sp|Q59940|IDH_STRMU ISOCITRATE DEHYDROGENASE [NADP] (OXALOSUCCINATE DECARBOXYLASE) (IDH) (NADP+-SPECIFIC ICDH) (IDP) >gi|1421814|gb|AAC44826.1| (U62799) isocitrate dehydrogenase [Streptococcus mutans]. (393 aa)
pfkBPutative fructose-1-phosphate kinase; Best Blastp Hit: sp|O31714|K1PF_BACSU 1-PHOSPHOFRUCTOKINASE (FRUCTOSE 1-PHOSPHATE KINASE) >gi|7434216|pir||A69627 fructose 1-phosphate kinase fruB - Bacillus subtilis >gi|2633810|emb|CAB13312.1| (Z99111) fructose-1-phosphate kinase [Bacillus subtilis] >gi|3282124|gb|AAC24914.1| (AF012285) fructose-1-phosphate kinase [Bacillus subtilis]; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (303 aa)
gtfASucrose phosphorylase, GtfA; Intracellular catabolism of sucrose. Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris. (481 aa)
galKGalactokinase, GalK; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. (390 aa)
gtfDglucosyltransferase-S; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family. (1462 aa)
gtfBglucosyltransferase-I; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family. (1476 aa)
gtfCglucosyltransferase-SI; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family. (1455 aa)
fruPPutative fructose-1-phosphate kinase; Best Blastp Hit: dbj|BAB04546.1| (AP001510) fructose 1-phosphate kinase [Bacillus halodurans]; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (310 aa)
SMU_1140cConserved hypothetical protein; Best Blastp Hit: sp|Q45499|SUHB_BACSU EXTRAGENIC SUPPRESSOR PROTEIN SUHB HOMOLOG >gi|7429926|pir||E69864 myo-inositol-1(or 4)-monophosphatase homolog yktC - Bacillus subtilis >gi|2633838|emb|CAB13340.1| (Z99111) similar to myo-inositol-1(or 4)-monophosphatase [Bacillus subtilis] >gi|3282150|gb|AAC24940.1| (AF012285) unknown [Bacillus subtilis]. (230 aa)
lacD2Tagatose 1,6-aldolase; Best Blastp Hit: sp|P26425|LACD_STRMU TAGATOSE 1,6-DIPHOSPHATE ALDOLASE (TAGATOSE-BISPHOSPHATE ALDOLASE) (D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE) >gi|322120|pir||F43258 tagatose-1,6-bisphosphate aldolase homolog LacD - Streptococcus mutans >gi|153676|gb|AAA26907.1| (M80797) tagatose 1,6-aldolase [Streptococcus mutans]. (329 aa)
mtlDBest Blastp Hit: sp|Q02418|MTLD_STRMU MANNITOL-1-PHOSPHATE 5-DEHYDROGENASE >gi|282315|pir||C44798 mannitol-1-phosphate 5-dehydrogenase (EC 1.1.1.17) mtlD - Streptococcus mutans >gi|153746|gb|AAA26942.1| (AF210133) mannitol-phosphate dehydrogenase [Streptococcus mutans]. (382 aa)
pfk6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. (337 aa)
rmlBPutative dTDP-glucose-4,6-dehydratase; Catalyzes the dehydration of dTDP-D-glucose to form dTDP-6- deoxy-D-xylo-4-hexulose via a three-step process involving oxidation, dehydration and reduction. (348 aa)
rmlAPutative glucose-1-phosphate thymidyltransferase; Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. (289 aa)
lacG6-phospho-beta-galactosidase; Best Blastp Hit: sp|P50978|LACG_STRMU 6-PHOSPHO-BETA-GALACTOSIDASE (BETA-D-PHOSPHOGALACTOSIDE GALACTOHYDROLASE) (PGALASE) (P-BETA-GAL) (PBG) >gi|433810|gb|AAA16450.1| (L18993) phospho-beta-galactosidase [Streptococcus mutans]; Belongs to the glycosyl hydrolase 1 family. (468 aa)
lacDTagatose-1,6-bisphosphate aldolase; Best Blastp Hit: sp|P26425|LACD_STRMU TAGATOSE 1,6-DIPHOSPHATE ALDOLASE (TAGATOSE-BISPHOSPHATE ALDOLASE) (D-TAGATOSE-1,6-BISPHOSPHATE ALDOLASE) >gi|322120|pir||F43258 tagatose-1,6-bisphosphate aldolase homolog LacD - Streptococcus mutans >gi|153676|gb|AAA26907.1| (M80797) tagatose 1,6-aldolase [Streptococcus mutans]. (325 aa)
lacCTagatose-6-phosphate kinase; Best Blastp Hit: sp|P26421|LACC_STRMU TAGATOSE-6-PHOSPHATE KINASE (PHOSPHOTAGATOKINASE) >gi|322119|pir||E43258 tagatose-6-phosphate kinase - Streptococcus mutans >gi|153675|gb|AAA26906.1| (M80797) tagatose 6-P kinase [Streptococcus mutans]; Belongs to the carbohydrate kinase PfkB family. LacC subfamily. (310 aa)
lacBBest Blastp Hit: pir||D43258 galactose-6-phosphate isomerase subunit LacB - Streptococcus mutans. (171 aa)
lacABest Blastp Hit: sp|P26423|LACA_STRMU GALACTOSE-6-PHOSPHATE ISOMERASE LACA SUBUNIT >gi|322117|pir||C43258 galactoside O-acetyltransferase (EC 2.3.1.18) - Streptococcus mutans >gi|153673|gb|AAA26904.1| (M80797) galactosidase acetyltransferase [Streptococcus mutans]. (142 aa)
lacRLactose repressor; Repressor of the lactose catabolism operon. Galactose-6- phosphate is the inducer. (251 aa)
glgAPutative starch (bacterial glycogen) synthase; Synthesizes alpha-1,4-glucan chains using ADP-glucose. (476 aa)
glgDPutative glycogen biosynthesis protein GlgD; Best Blastp Hit: dbj|BAB04805.1| (AP001510) required for glycogen biosynthesis [Bacillus halodurans]. (377 aa)
glgCPutative glucose-1-phosphate adenylyltransferase; Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc; Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. (381 aa)
glgBPutative 1,4-alpha-glucan branching enzyme; Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position; Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. (628 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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