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dnaG dnaG SMU_952 SMU_952 dnaJ dnaJ metE metE queC queC kitH kitH cdd cdd pepN pepN adh adh pyrC pyrC deoB deoB pepV pepV hisI hisI hisD hisD add add adcA adcA murC2 murC2 SMU_1438c SMU_1438c rnj rnj rnz rnz SMU_1487 SMU_1487 ftsH ftsH cysS cysS pepQ pepQ rnh rnh cah cah fpg fpg ybeY ybeY clpX clpX ppaC ppaC SMU_1733c SMU_1733c accD accD manA manA comEB comEB fbaA fbaA uvrA uvrA sloR sloR SMU_1867c SMU_1867c folE folE nrdR nrdR htpX htpX rpoC rpoC rs14 rs14 nifU nifU SMU_274 SMU_274 tadA tadA SMU_328 SMU_328 gltX gltX rnj-2 rnj-2 tsaD tsaD luxS luxS priA priA dpr dpr ileS ileS feoA feoA alaS alaS pepT pepT SMU_752 SMU_752
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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dnaGPutative DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (592 aa)
SMU_952Putative methyltransferase; Best Blastp Hit: pir||B69751 conserved hypothetical protein ybgG - Bacillus subtilis >gi|2632527|emb|CAB12035.1| (Z99105) similar to hypothetical proteins [Bacillus subtilis] >gi|3599664|dbj|BAA33139.1| (AB006424) ybgG [Bacillus subtilis]. (316 aa)
dnaJHeat shock protein DnaJ (HSP-40); Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions betwe [...] (377 aa)
metEPutative homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (745 aa)
queCPutative ATPase, confers aluminum resistance; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). (217 aa)
kitHPutative thymidine kinase; Best Blastp Hit: sp|P47848|KITH_STRGC THYMIDINE KINASE >gi|703442|gb|AAB02289.1| (L40415) thymidine kinase [Streptococcus gordonii]. (194 aa)
cddPutative cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (128 aa)
pepNAminopeptidase N, PepN; Best Blastp Hit: emb|CAB50785.1| (AJ007700) aminopeptidase N [Streptococcus thermophilus]. (849 aa)
adhBest Blastp Hit: gb|AAG07017.1|AE004783_2 (AE004783) alcohol dehydrogenase class III [Pseudomonas aeruginosa]; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (372 aa)
pyrCPutative dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (422 aa)
deoBPutative phosphopentomutase; Phosphotransfer between the C1 and C5 carbon atoms of pentose; Belongs to the phosphopentomutase family. (403 aa)
pepVPutative dipeptidase; Best Blastp Hit: gb|AAC45369.1| (U78036) dipeptidase [Lactococcus lactis]. (470 aa)
hisIPutative phosphoribosyl-ATP pyrophosphatase / phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (109 aa)
hisDPutative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa)
addPutative adenosine deaminase; Best Blastp Hit: pir||T35340 probable adenosine deaminase - Streptomyces coelicolor >gi|4835327|emb|CAB42949.1| (AL049863) putative adenosine deaminase [Streptomyces coelicolor A3(2)]; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily. (349 aa)
adcAPutative surface adhesin; Best Blastp Hit: emb|CAA96185.1| (Z71552) AdcA protein [Streptococcus pneumoniae]; Belongs to the bacterial solute-binding protein 9 family. (506 aa)
murC2Best Blastp Hit: pir||T31440 UDP-N-acetylmuramyl tripeptide synthetase homolog murC - Heliobacillus mobilis >gi|3820539|gb|AAC84012.1| (AF080002) UDP-N-acetylmuramyl tripeptide synthetase MurC [Heliobacillus mobilis]. (447 aa)
SMU_1438cPutative Zn-dependent protease; Best Blastp Hit: emb|CAA71521.1| (Y10497) protease A [Myxococcus xanthus]. (232 aa)
rnjConserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (554 aa)
rnzConserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (309 aa)
SMU_1487Best Blastp Hit: pir||D72115 conserved hypothetical protein CP0630 [imported] - Chlamydophila pneumoniae (strains CWL029 and AR39) >gi|4376408|gb|AAD18296.1| (AE001600) Hypothetical Protein [Chlamydophila pneumoniae] >gi|7189544|gb|AAF38445.1| (AE002221) conserved hypothetical protein [Chlamydophila pneumoniae AR39] >gi|8978516|dbj|BAA98353.1| (AP002545) hypothetical protein [Chlamydophila pneumoniae]. (381 aa)
ftsHPutative cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (656 aa)
cysSBest Blastp Hit: sp|Q06752|SYC_BACSU CYSTEINYL-TRNA SYNTHETASE (CYSTEINE--TRNA LIGASE) (CYSRS) >gi|541406|pir||C53402 cysteine--tRNA ligase (EC 6.1.1.16) cysS - Bacillus subtilis >gi|289284|gb|AAA21798.1| (L14580) cysteinyl-tRNA synthetase [Bacillus subtilis] >gi|467482|dbj|BAA05328.1| (D26185) cysteinyl-tRNA synthetase [Bacillus subtilis] >gi|499303|emb|CAA52167.1| (X73989) cysteine--tRNA ligase [Bacillus subtilis] >gi|2632361|emb|CAB11870.1| (Z99104) cysteinyl-tRNA synthetase [Bacillus subtilis]; Belongs to the class-I aminoacyl-tRNA synthetase family. (447 aa)
pepQPutative dipeptidase PepQ; Best Blastp Hit: gb|AAC46293.1| (AF014460) PepQ [Streptococcus mutans]. (359 aa)
rnhPutative ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (260 aa)
cahBest Blastp Hit: dbj|BAB04079.1| (AP001508) carbonic anhydrase precursor [Bacillus halodurans]. (256 aa)
fpgPutative formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity). (273 aa)
ybeYConserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (164 aa)
clpXATP-dependent protease Clp, ATPase subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (410 aa)
ppaCBest Blastp Hit: sp|O68579|PPAC_STRMU PROBABLE MANGANESE-DEPENDENT INORGANIC PYROPHOSPHATASE (PYROPHOSPHATE PHOSPHO-HYDROLASE) (PPASE) >gi|2952533|gb|AAC05778.1| (AF051356) putative exopolyphosphatase [Streptococcus mutans] >gi|3403205|gb|AAC29042.1| (AF050517) unknown [Streptococcus mutans]; Belongs to the PPase class C family. (310 aa)
SMU_1733cPutative SNF helicase; Best Blastp Hit: emb|CAA67095.1| (X98455) SNF [Bacillus cereus]. (1030 aa)
accDPutative acetyl-CoA carboxylase beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (288 aa)
manABest Blastp Hit: sp|Q59935|MANA_STRMU MANNOSE-6-PHOSPHATE ISOMERASE (PHOSPHOMANNOSE ISOMERASE) (PMI) (PHOSPHOHEXOMUTASE) >gi|451216|dbj|BAA04021.1| (D16594) Mannosephosphate Isomerase [Streptococcus mutans]. (316 aa)
comEBPutative deoxycytidylate deaminase; Best Blastp Hit: dbj|BAB05053.1| (AP001511) late competence operon required for DNA binding and uptake [Bacillus halodurans]. (150 aa)
fbaABest Blastp Hit: dbj|BAB16889.1| (AB050113) class-II aldolase [Streptococcus bovis]. (293 aa)
uvrAPutative excinuclease ABC (subunit A); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (943 aa)
sloRPutative metal-dependent transcriptional regulator; Best Blastp Hit: gb|AAF81675.1|AF232688_4 (AF232688) SloR [Streptococcus mutans]. (217 aa)
SMU_1867cPutative alcohol dehydrogenase; Best Blastp Hit: gb|AAG09966.1|AF248037_1 (AF248037) alcohol dehydrogenase [Streptococcus agalactiae]. (349 aa)
folEBest Blastp Hit: sp|O33723|GCH1_STRPY GTP CYCLOHYDROLASE I (GTP-CH-I) >gi|3242315|emb|CAA04237.1| (AJ000685) GTP cyclohydrolase [Streptococcus pyogenes]. (192 aa)
nrdRConserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (163 aa)
htpXBest Blastp Hit: sp|O30795|HTPX_STRGC PUTATIVE HEAT SHOCK PROTEIN HTPX >gi|11277180|pir||T48855 probable heat shock protein HtpX [imported] - Streptococcus gordonii >gi|2407215|gb|AAB70525.1| (AF017421) putative heat shock protein HtpX [Streptococcus gordonii]; Belongs to the peptidase M48B family. (299 aa)
rpoCDNA-dependent RNA polymerase, beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1218 aa)
rs1430S ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
nifUPutative nitrogen fixation-like protein, NifU; Best Blastp Hit: sp|O32163|NIFU_BACSU NIFU-LIKE PROTEIN >gi|7427865|pir||E70019 nitrogen fixation protein nifU homolog yurV - Bacillus subtilis >gi|2635764|emb|CAB15257.1| (Z99120) similar to NifU protein homolog [Bacillus subtilis]. (144 aa)
SMU_274Best Blastp Hit: sp|P44990|SGBU_HAEIN PUTATIVE HEXULOSE-6-PHOSPHATE ISOMERASE (HUMPI) >gi|1074611|pir||G64164 hypothetical protein HI1026 - Haemophilus influenzae (strain Rd KW20) >gi|1574058|gb|AAC22686.1| (U32783) hexulose-6-phosphate isomerase, putative [Haemophilus influenzae Rd]. (287 aa)
tadAPutative deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (156 aa)
SMU_328Putative carbonic anhydrase; Best Blastp Hit: pir||T34963 hypothetical protein SC4A10.26 - Streptomyces coelicolor >gi|5689965|emb|CAB52002.1| (AL109663) hypothetical protein [Streptomyces coelicolor A3(2)]. (166 aa)
gltXPutative glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (485 aa)
rnj-2Conserved hypothetical protein; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (560 aa)
tsaDPutative glycoprotein endopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (336 aa)
luxSPutative autoinducer-2 production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family. (160 aa)
priAPrimosomal replication factor Y (primosomal protein N'); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (794 aa)
dprPeroxide resistance protein Dpr; Best Blastp Hit: dbj|BAA96472.1| (AB036428) Dpr [Streptococcus mutans]; Belongs to the Dps family. (175 aa)
ileSisoleucine-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (930 aa)
feoABest Blastp Hit: pir||F75422 ferrous iron transport protein A - Deinococcus radiodurans (strain R1) >gi|6458962|gb|AAF10791.1|AE001970_6 (AE001970) ferrous iron transport protein A [Deinococcus radiodurans]. (158 aa)
alaSPutative alanyl-tRNA synthetase (alanine--tRNA ligase); Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (872 aa)
pepTPutative tripeptidase (peptidase T); Cleaves the N-terminal amino acid of tripeptides. Belongs to the peptidase M20B family. (406 aa)
SMU_752Conserved hypothetical protein; Best Blastp Hit: dbj|BAA90855.1| (AB031213) YdcK [Bacillus halodurans] >gi|10173145|dbj|BAB04251.1| (AP001508) unknown conserved protein in B. subtilis [Bacillus halodurans]; Belongs to the SprT family. (145 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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