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SMU_739c SMU_739c SMU_76 SMU_76 gbpD gbpD fruA fruA fruB fruB SMU_806c SMU_806c SMU_815 SMU_815 SMU_817 SMU_817 SMU_836 SMU_836 msmE msmE gtfD gtfD SMU_959c SMU_959c wapA wapA SMU_998 SMU_998 yidC2 yidC2 sloC sloC SMU_1904c SMU_1904c atmB atmB SMU_1942c SMU_1942c SMU_197c SMU_197c sacB sacB dexA dexA SMU_2061 SMU_2061 gbpA gbpA opuCc opuCc SMU_2146c SMU_2146c SMU_2147c SMU_2147c gbpB gbpB SMU_242c SMU_242c SMU_252 SMU_252 gtfB gtfB gtfC gtfC wapE wapE SMU_1093 SMU_1093 SMU_1121c SMU_1121c SMU_1131c SMU_1131c dacA dacA pstS pstS SMU_1169c SMU_1169c SMU_1177c SMU_1177c SMU_1196c SMU_1196c SMU_1213c SMU_1213c SMU_1217c SMU_1217c gbpC gbpC SMU_1411 SMU_1411 SMU_145 SMU_145 SMU_1479 SMU_1479 SMU_1520 SMU_1520 endA endA malX malX SMU_1631 SMU_1631 livK livK oppA oppA yidC1 yidC1 SMU_367 SMU_367 brpA brpA SMU_448 SMU_448 SMU_459 SMU_459 SMU_503c SMU_503c SMU_510c SMU_510c SMU_609 SMU_609 spaP spaP SMU_63c SMU_63c prtM prtM SMU_651c SMU_651c SMU_689 SMU_689 SMU_690 SMU_690 SMU_707c SMU_707c SMU_711 SMU_711
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SMU_739cHypothetical protein; Best Blastp Hit: gi|6319355 Ybl113cp [Saccharomyces cerevisiae] >gi|2131309|pir||S70305 hypothetical protein YBL113c - yeast (Saccharomyces cerevisiae). (518 aa)
SMU_76Best Blastp Hit: gb|AAD00279.1| (U78599) putative N-acetyl-muramidase [Streptococcus mutans]. (195 aa)
gbpDGlucan-binding protein D with lipase activity; Best Blastp Hit: gb|AAF89976.1|AF206272_2 (AF206272) BglB [Streptococcus mutans]. (726 aa)
fruAFructan hydrolase; This protein is a fructanase enzyme which degrades levans and inulins to fructose and also cleaves sucrose into glucose and fructose and can therefore function as an extracellular invertase; Belongs to the glycosyl hydrolase 32 family. (1423 aa)
fruBFructan hydrolase; Best Blastp Hit: gb|AAD28639.1| (U78296) FruB [Streptococcus mutans]. (519 aa)
SMU_806cPutative glutamine ABC transporter, permease protein; Best Blastp Hit: gb|AAF16724.1|AF141644_1 (AF141644) putative integral membrane protein [Lactococcus lactis]. (728 aa)
SMU_815Best Blastp Hit: pir||B72357 amino acid ABC transporter, periplasmic amino acid-binding protein - Thermotoga maritima (strain MSB8) >gi|4981112|gb|AAD35678.1|AE001734_5 (AE001734) amino acid ABC transporter, periplasmic amino acid-binding protein [Thermotoga maritima]. (271 aa)
SMU_817Best Blastp Hit: sp|P54535|YQIX_BACSU PROBABLE AMINO-ACID ABC TRANSPORTER EXTRACELLULAR BINDING PROTEIN YQIX PRECURSOR >gi|7442313|pir||F69962 amino acid ABC transporter (binding protein) homolog yqiX - Bacillus subtilis >gi|1303949|dbj|BAA12604.1| (D84432) YqiX [Bacillus subtilis] >gi|2634832|emb|CAB14329.1| (Z99116) similar to amino acid ABC transporter (binding protein) [Bacillus subtilis]. (271 aa)
SMU_836Hypothetical protein; Best Blastp Hit: pir||C60328 hypothetical protein 2 (sr 5' region) - Streptococcus mutans (strain OMZ175, serotype f). (544 aa)
msmEMultiple sugar-binding ABC transporter, sugar-binding protein precursor MsmE; Involved in a binding protein-dependent transport system responsible for the uptake of melibiose, raffinose and isomaltotriose. (420 aa)
gtfDglucosyltransferase-S; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family. (1462 aa)
SMU_959cHypothetical protein. (84 aa)
wapABest Blastp Hit: sp|P11000|WAPA_STRMU WALL-ASSOCIATED PROTEIN PRECURSOR >gi|98001|pir||S06992 wall-associated protein A precursor - Streptococcus mutans >gi|153858|gb|AAA88608.1| (M37842) wall-associated protein [Streptococcus mutans]. (453 aa)
SMU_998Putative ABC transporter, periplasmic ferrichrome-binding protein; Best Blastp Hit: emb|CAA06500.1| (AJ005352) lipoprotein [Staphylococcus aureus]. (340 aa)
yidC2Putative inner membrane protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity). Partially complements an E.coli yidC depletion experiment. (310 aa)
sloCPutative ABC transporter, metal binding lipoprotein; Part of an ATP-driven transport system for a metal; probably for manganese. Also acts as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection. It may contribute to the formation and accumulation of dental plaque; Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily. (306 aa)
SMU_1904cHypothetical protein; Best Blastp Hit: emb|CAA11803.1| (AJ224003) hypothetical protein [Carnobacterium divergens]. (340 aa)
atmBPutative membrane lipoprotein; Best Blastp Hit: emb|CAB59827.1| (AJ012388) hypothetical protein [Lactococcus lactis]; Belongs to the nlpA lipoprotein family. (280 aa)
SMU_1942cPutative amino acid binding protein; Best Blastp Hit: gb|AAC45332.1| (U97348) basic surface protein [Lactobacillus fermentum]. (267 aa)
SMU_197cHypothetical protein; Best Blastp Hit: emb|CAB36621.1| (AL034390) hypothetical protein L1156.02 [Leishmania major]. (808 aa)
sacBLevansucrase precursor; Best Blastp Hit: sp|P11701|SACB_STRMU LEVANSUCRASE## PRECURSOR (BETA-D-FRUCTOFURANOSYL TRANSFERASE) (SUCROSE 6-FRUCTOSYL TRANSFERASE) >gi|79999|pir||B28551 levansucrase (EC 2.4.1.10) precursor - Streptococcus mutans (strain GS-5) >gi|153636|gb|AAA88584.1| (M18954) fructosyltransferase [Streptococcus mutans]; Belongs to the glycosyl hydrolase 68 family. (795 aa)
dexADextranase precursor; May play a role in sucrose-independent adherence to the pellicle-coated tooth surface; Belongs to the glycosyl hydrolase 66 family. (850 aa)
SMU_2061Hypothetical protein. (217 aa)
gbpABest Blastp Hit: pir||A37184 glucan-binding protein - Streptococcus mutans >gi|153638|gb|AAA26894.1| (M30945) glucan-binding protein (gbp) [Streptococcus mutans]. (565 aa)
opuCcPutative ABC transporter; Best Blastp Hit: sp|O32243|OPCC_BACSU GLYCINE BETAINE/CARNITINE/CHOLINE-BINDING PROTEIN PRECURSOR (OSMOPROTECTANT-BINDING PROTEIN) >gi|7474863|pir||E69670 glycine betaine/carnitine/choline ABC transporter (osmoprotec) opuCC - Bacillus subtilis >gi|2635894|emb|CAB15386.1| (Z99121) glycine betaine/carnitine/choline ABC transporter (osmoprotectant-binding protein) [Bacillus subtilis]. (311 aa)
SMU_2146cHypothetical protein; Best Blastp Hit: gb|AAF66691.1|AF144681_1 (AF144681) immunodominant antigen A [Staphylococcus aureus]. (201 aa)
SMU_2147cConserved hypothetical protein; Best Blastp Hit: emb|CAA69725.1| (Y08498) aggregation promoting protein [Lactobacillus gasseri]. (288 aa)
gbpBBest Blastp Hit: gb|AAD00288.1| (U78607) putative secreted protein [Streptococcus mutans]. (431 aa)
SMU_242cBest Blastp Hit: pir||A72357 amino acid ABC transporter, permease protein - Thermotoga maritima (strain MSB8) >gi|4981111|gb|AAD35677.1|AE001734_4 (AE001734) amino acid ABC transporter, permease protein [Thermotoga maritima]. (517 aa)
SMU_252Hypothetical protein. (257 aa)
gtfBglucosyltransferase-I; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family. (1476 aa)
gtfCglucosyltransferase-SI; Production of extracellular glucans, that are thought to play a key role in the development of the dental plaque because of their ability to adhere to smooth surfaces and mediate the aggregation of bacterial cells and food debris; Belongs to the glycosyl hydrolase 70 family. (1455 aa)
wapEHypothetical protein; Best Blastp Hit: gi|6324372 anchorage subunit of a-agglutinin; Aga1p [Saccharomyces cerevisiae] >gi|416592|sp|P32323|AGA1_YEAST A-AGGLUTININ ATTACHMENT SUBUNIT PRECURSOR >gi|101170|pir||A41258 a-agglutinin core protein AGA1 - yeast (Saccharomyces cerevisiae) >gi|170964|gb|AAA34382.1| (M60590) a-agglutinin core subunit [Saccharomyces cerevisiae] >gi|1302552|emb|CAA96325.1| (Z71659) ORF YNR044w [Saccharomyces cerevisiae]. (507 aa)
SMU_1093Putative ABC transporter, permease protein; Best Blastp Hit: pir||F69762 transporter homolog yclI - Bacillus subtilis >gi|1805444|dbj|BAA09006.1| (D50453) homologue of hypothetical protein in a rapamycin synthesis gene cluster of Streptomyces hygroscopicus [Bacillus subtilis] >gi|2632675|emb|CAB12182.1| (Z99106) similar to transporter [Bacillus subtilis]. (502 aa)
SMU_1121cPutative ABC transporter; Best Blastp Hit: sp|O05252|YUFN_BACSU HYPOTHETICAL LIPOPROTEIN YUFN PRECURSOR >gi|7429430|pir||C70009 ABC transporter (lipoprotein) homolog yufN - Bacillus subtilis >gi|1934811|emb|CAB07936.1| (Z93937) unknown [Bacillus subtilis] >gi|2635650|emb|CAB15143.1| (Z99120) similar to ABC transporter (lipoprotein) [Bacillus subtilis]. (349 aa)
SMU_1131cHypothetical protein. (87 aa)
dacAPutative D-alanyl-D-alanine carboxypeptidase; Best Blastp Hit: emb|CAA67776.1| (X99400) D,D-carboxypeptidase [Streptococcus pneumoniae]; Belongs to the peptidase S11 family. (414 aa)
pstSPutative ABC transporter, phosphate-binding protein; Best Blastp Hit: sp|P46338|YQGG_BACSU PROBABLE ABC TRANSPORTER BINDING PROTEIN YQGG PRECURSOR >gi|7428856|pir||A69956 phosphate ABC transporter (binding protein) homolog yqgG - Bacillus subtilis >gi|903303|dbj|BAA09581.1| (D58414) ORF108 [Bacillus subtilis] >gi|1303854|dbj|BAA12510.1| (D84432) YqgG [Bacillus subtilis] >gi|2634932|emb|CAB14429.1| (Z99116) alternate gene name: yzmB similar to phosphate ABC transporter (binding protein) [Bacillus subtilis]. (287 aa)
SMU_1169cPutative thioredoxin family protein; Best Blastp Hit: dbj|BAB05296.1| (AP001512) cytochrome c biogenesis (thioredoxin) [Bacillus halodurans]. (187 aa)
SMU_1177cPutative ABC transporter, glutamine binding protein; Best Blastp Hit: gb|AAC35851.1| (AF086736) amino acid-binding protein Abp [Streptococcus uberis]. (277 aa)
SMU_1196cConserved hypothetical protein; Best Blastp Hit: emb|CAA76857.1| (Y17797) hypothetical protein [Enterococcus faecalis]. (206 aa)
SMU_1213cPutative 5'-nucleotidase precursor; Best Blastp Hit: dbj|BAB03745.1| (AP001507) nucleotidase precursor [Bacillus halodurans]; Belongs to the 5'-nucleotidase family. (704 aa)
SMU_1217cPutative ABC transporter, amino acid binding protein; Best Blastp Hit: sp|P42400|YCKB_BACSU PROBABLE ABC TRANSPORTER EXTRACELLULAR BINDING PROTEIN YCKB PRECURSOR (ORF2) >gi|7442312|pir||D69760 amino acid ABC transporter (binding protein) homolog yckB - Bacillus subtilis >gi|2632624|emb|CAB12132.1| (Z99105) similar to amino acid ABC transporter (binding protein) [Bacillus subtilis]; Belongs to the bacterial solute-binding protein 3 family. (283 aa)
gbpCGlucan-binding protein C, GbpC; Best Blastp Hit: dbj|BAA12713.1| (D85031) glucan-binding protein C [Streptococcus mutans]. (583 aa)
SMU_1411Conserved hypothetical protein; Best Blastp Hit: pir||D71676 bicyclomycin resistance protein (bcr2) RP698 - Rickettsia prowazekii >gi|3861234|emb|CAA15134.1| (AJ235272) BICYCLOMYCIN RESISTANCE PROTEIN (bcr2) [Rickettsia prowazekii]. (391 aa)
SMU_145Conserved hypothetical protein; Best Blastp Hit: dbj|BAB03956.1| (AP001507) multidrug-efflux transporter [Bacillus halodurans]. (394 aa)
SMU_1479Conserved hypothetical protein. (58 aa)
SMU_1520Putative ABC transporter, glutamine binding protein; Best Blastp Hit: sp|P45678|PEB1_CAMJE MAJOR CELL-BINDING FACTOR PRECURSOR (CBF1) (PEB1) >gi|1072926|pir||A48518 probable ABC-type amino-acid transporter periplasmic solute-binding protein Cj0921c precursor [imported] - Campylobacter jejuni (strain NCTC 11168) >gi|388565|gb|AAA02919.1| (L13662) major cell-binding factor [Campylobacter jejuni] >gi|6968358|emb|CAB73178.1| (AL139076) probable ABC-type amino-acid transporter periplasmic solute-binding protein [Campylobacter jejuni]. (270 aa)
endAPutative membrane nuclease EndA; Best Blastp Hit: sp|Q03158|NUCE_STRPN DNA-ENTRY NUCLEASE (COMPETENCE-SPECIFIC NUCLEASE) >gi|98025|pir||S10641 endA protein - Streptococcus pneumoniae >gi|47374|emb|CAA38134.1| (X54225) membrane nuclease [Streptococcus pneumoniae]. (293 aa)
malXPutative maltose/maltodextrin ABC transporter, sugar-binding protein MalX; Best Blastp Hit: sp|P29850|MALX_STRPN MALTOSE/MALTODEXTRIN-BINDING PROTEIN PRECURSOR >gi|479206|pir||S32569 malX protein - Streptococcus pneumoniae >gi|153723|gb|AAA26925.1| (L08611) MalX [Streptococcus pneumoniae]. (415 aa)
SMU_1631Putative peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (258 aa)
livKBest Blastp Hit: pir||C72290 branched chain amino acid ABC transporter, periplasmic amino acid-binding protein - Thermotoga maritima (strain MSB8) >gi|4981682|gb|AAD36211.1|AE001771_4 (AE001771) branched chain amino acid ABC transporter, periplasmic amino acid-binding protein [Thermotoga maritima]. (390 aa)
oppAPutative oligopeptide ABC transporter, substrate-binding protein OppA; Best Blastp Hit: gb|AAD17886.1| (AF100456) hyaluronate-associated protein precursor [Streptococcus equi]. (549 aa)
yidC1Conserved hypothetical protein; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins (By similarity). Partially complements an E.coli yidC depletion experiment. (271 aa)
SMU_367Hypothetical protein; Best Blastp Hit: gb|AAB94651.1| (U96107) SceB precursor [Staphylococcus carnosus]. (211 aa)
brpAPutative transcriptional regulator; Involved in biofilm formation, cell division, autolysis and the regulation of acid and oxidative stress tolerance. May be associated with systemic virulence in blood. Belongs to the LytR/CpsA/Psr (LCP) family. (406 aa)
SMU_448Hypothetical protein; Best Blastp Hit: pir||F69859 conserved hypothetical protein ykoJ - Bacillus subtilis >gi|2632048|emb|CAA05607.1| (AJ002571) YkoJ [Bacillus subtilis] >gi|2633682|emb|CAB13185.1| (Z99110) similar to hypothetical proteins from B. subtilis [Bacillus subtilis]. (126 aa)
SMU_459Best Blastp Hit: sp|P54952|YXEM_BACSU PROBABLE AMINO-ACID ABC TRANSPORTER BINDING PROTEIN YXEM PRECURSOR >gi|7442311|pir||G70075 amino acid ABC transporter (binding protein) homolog yxeM - Bacillus subtilis## >gi|1408498|dbj|BAA08329.1| (D45912) homologous to Gln-binding periplasmic proteins [Bacillus subtilis] >gi|2636496|emb|CAB15986.1| (Z99124) similar to amino acid ABC transporter (binding protein) [Bacillus subtilis]. (273 aa)
SMU_503cHypothetical protein. (211 aa)
SMU_510cHypothetical protein; Best Blastp Hit: emb|CAA59264.1| (X84793) streptodornase [Streptococcus pyogenes]. (211 aa)
SMU_609Best Blastp Hit: pir||A60328 40K cell wall protein precursor (sr 5' region) - Streptococcus mutans (strain OMZ175, serotype f). (611 aa)
spaPCell surface antigen SpaP; Surface protein antigen implicated in dental caries; Belongs to the SpaP/Ssp5/SpaA family. (1562 aa)
SMU_63cBest Blastp Hit: pir||T33369 hypothetical protein H02F09.3 - Caenorhabditis elegans >gi|3319425|gb|AAC64622.1| (AF077538) unknown [Caenorhabditis elegans]. (613 aa)
prtMPutative protease maturation protein precursor; Plays a major role in protein secretion by helping the post- translocational extracellular folding of several secreted proteins. (333 aa)
SMU_651cPutative ABC transporter, substrate-binding protein; Best Blastp Hit: gb|AAG05982.1|AE004688_4 (AE004688) conserved hypothetical protein [Pseudomonas aeruginosa]. (342 aa)
SMU_689Hypothetical protein; Best Blastp Hit: pir||C60328 hypothetical protein 2 (sr 5' region) - Streptococcus mutans (strain OMZ175, serotype f). (979 aa)
SMU_690Hypothetical protein. (195 aa)
SMU_707cPutative endolysin; Best Blastp Hit: emb|CAA72266.1| (Y11477) endolysin [Bacteriophage Bastille]. (282 aa)
SMU_711Conserved hypothetical protein; Best Blastp Hit: gb|AAB69173.1| (AF005097) unknown [Lactococcus lactis]. (129 aa)
Your Current Organism:
Streptococcus mutans
NCBI taxonomy Id: 210007
Other names: S. mutans UA159, Streptococcus mutans UA159, Streptococcus mutans str. UA159
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